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    CCL24 C-C motif chemokine ligand 24 [ Homo sapiens (human) ]

    Gene ID: 6369, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The Role of CCL24 in Primary Sclerosing Cholangitis: Bridging Patient Serum Proteomics to Preclinical Data.

    The Role of CCL24 in Primary Sclerosing Cholangitis: Bridging Patient Serum Proteomics to Preclinical Data.
    Greenman R, Snir T, Katav A, Aricha R, Mishalian I, Hay O, Frankel M, Lawler J, Saffioti F, Pinzani M, Thorburn D, Peled A, Mor A, Vaknin I., Free PMC Article

    02/15/2024
    CCL24/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation.

    CCL24/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation.
    Wang Z, Xu H, Chen M, Lu Y, Zheng L, Ma L., Free PMC Article

    08/17/2023
    CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment.

    CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment.
    Al-Jaberi L, Simonds MM, Brescia AMC.

    07/7/2023
    CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis.

    CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis.
    Greenman R, Segal-Salto M, Barashi N, Hay O, Katav A, Levi O, Vaknin I, Aricha R, Aharoni S, Snir T, Mishalian I, Olam D, Amer J, Salhab A, Safadi R, Maor Y, Trivedi P, Weston CJ, Saffioti F, Hall A, Pinzani M, Thorburn D, Peled A, Mor A., Free PMC Article

    06/23/2023
    Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.

    Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.
    Mancebo-Pérez C, Vidal M, Aguilar R, Barrios D, Bardají A, Ome-Kaius M, Menéndez C, Rogerson SJ, Dobaño C, Moncunill G, Requena P., Free PMC Article

    12/10/2022
    CCL24 Protects Renal Function by Controlling Inflammation in Podocytes.

    CCL24 Protects Renal Function by Controlling Inflammation in Podocytes.
    Wang Y, Wu X, Geng M, Ding J, Lv K, Du H, Ding J, Pei W, Hu X, Gu J, Wang L, Zhang Y, Gao J., Free PMC Article

    12/11/2021
    The transcriptome-wide association search for genes and genetic variants which associate with BMI and gestational weight gain in women with type 1 diabetes.

    The transcriptome-wide association search for genes and genetic variants which associate with BMI and gestational weight gain in women with type 1 diabetes.
    Ludwig-Słomczyńska AH, Seweryn MT, Kapusta P, Pitera E, Mantaj U, Cyganek K, Gutaj P, Dobrucka Ł, Wender-Ożegowska E, Małecki MT, Wołkow PP., Free PMC Article

    10/2/2021
    Increased CCL24 and CXCL7 levels in the cerebrospinal fluid of patients with neurosyphilis.

    Increased CCL24 and CXCL7 levels in the cerebrospinal fluid of patients with neurosyphilis.
    Li XX, Zhang J, Wang ZY, Chen SQ, Zhou WF, Wang TT, Man XY, Zheng M., Free PMC Article

    07/17/2021
    Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis.

    Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis.
    Meguro A, Ishihara M, Petrek M, Yamamoto K, Takeuchi M, Mrazek F, Kolek V, Benicka A, Yamane T, Shibuya E, Yoshino A, Isomoto A, Ota M, Yatsu K, Shijubo N, Nagai S, Yamaguchi E, Yamaguchi T, Namba K, Kaburaki T, Takase H, Morimoto SI, Hori J, Kono K, Goto H, Suda T, Ikushima S, Ando Y, Takenaka S, Takeuchi M, Yuasa T, Sugisaki K, Ohguro N, Hiraoka M, Kitaichi N, Sugiyama Y, Horita N, Asukata Y, Kawagoe T, Kimura I, Ishido M, Inoko H, Mochizuki M, Ohno S, Bahram S, Remmers EF, Kastner DL, Mizuki N., Free PMC Article

    06/26/2021
    CCL24 displays antimicrobial activity against S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa.

    Eotaxin-3 (CCL26) exerts innate host defense activities that are modulated by mast cell proteases.
    Gela A, Kasetty G, Jovic S, Ekoff M, Nilsson G, Mörgelin M, Kjellström S, Pease JE, Schmidtchen A, Egesten A.

    07/27/2020
    The eotaxin family currently includes three members: eotaxin-1 (CCL11), eotaxin-2 (CCL24), and eotaxin-3 (CCL26), and each was identified based on its ability to bind the chemokine receptor, CCR3 [Review].

    An emerging role for eotaxins in neurodegenerative disease.
    Huber AK, Giles DA, Segal BM, Irani DN.

    07/6/2019
    This study concludes that serum CCL11, CCL24 and CCL26 are upregulated in primary biliary cholangitis (PBC); CCL11 and CCL26 are associated with fibrotic progression of PBC, but CCL24 is not.

    Association of CCL11, CCL24 and CCL26 with primary biliary cholangitis.
    Lin F, Shi H, Liu D, Zhang Z, Luo W, Mao P, Zhong R, Liang Y, Yang Z.

    05/11/2019
    results revealed that melatonin attenuated chemokine CCL24 levels through inhibition of the JNK pathway to hinder human osteosarcoma cell invasion, thereby highlighting the therapeutic potential of melatonin for osteosarcoma metastasis.

    Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway.
    Lu KH, Su SC, Lin CW, Hsieh YH, Lin YC, Chien MH, Reiter RJ, Yang SF.

    12/22/2018
    Study showed that CCL24 was upregulated in hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis in HCC patients . Also, CCL24 was associated with the metastatic potential of HCC cell lines and promoted proliferation, migration, and invasion.

    CCL24 contributes to HCC malignancy via RhoB- VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis.
    Jin L, Liu WR, Tian MX, Jiang XF, Wang H, Zhou PY, Ding ZB, Peng YF, Dai Z, Qiu SJ, Zhou J, Fan J, Shi YH., Free PMC Article

    02/24/2018
    Mean eotaxin 2 concentrations in nasal fluid in patients with perennial allergic rhinitis and nonallergic and allergic chronic rhinosinusitis with nasal polyps patients were significantly higher in comparison to control subjects.

    Effects of Fluticasone Furoate Nasal Spray on Parameters of Eosinophilic Inflammation in Patients With Nasal Polyposis and Perennial Allergic Rhinitis.
    Špadijer Mirković C, Perić A, Vukomanović Đurđević B, Vojvodić D.

    08/26/2017
    Review: eotaxins (CCL11, CCL24, and CCL26) play key role(s) during symptomatic inflammatory responses raised in response to allergic crisis of allergic asthma and atopic dermatitis

    An Overlook to the Characteristics and Roles Played by Eotaxin Network in the Pathophysiology of Food Allergies: Allergic Asthma and Atopic Dermatitis.
    Ahmadi Z, Hassanshahi G, Khorramdelazad H, Zainodini N, Koochakzadeh L.

    03/11/2017
    HMGB1 did not elicit chemotaxis of human eosinophils alone and had no effect in combination with the eosinophil chemotactic agent, eotaxin-2 (CCL24).

    Physiologic concentrations of HMGB1 have no impact on cytokine-mediated eosinophil survival or chemotaxis in response to Eotaxin-2 (CCL24).
    Dyer KD, Rosenberg HF., Free PMC Article

    03/26/2016
    these data suggest that CCL26 and CCL24 are likely involved in the pathogenesis of chronic nasal hypereosinophilia, with a complex cooperation and different involvement of the various members of eotaxin family.

    Nasal fluid release of eotaxin-3 and eotaxin-2 in persistent sinonasal eosinophilic inflammation.
    De Corso E, Baroni S, Battista M, Romanello M, Penitente R, Di Nardo W, Passali GC, Sergi B, Fetoni AR, Bussu F, Zuppi C, Paludetti G.

    04/25/2015
    CCL11, CCL24, and CCL26 are increased in TB patients; hence, it seems that TB suppresses Th1 and the classic function of macrophages subsequently by inducing the chemokines' expression

    All eotaxins CCL11, CCL24 and CCL26 are increased but to various extents in pulmonary tuberculosis patients.
    Sharifabadi AR, Hassanshahi G, Ghalebi SR, Arababadi MK, Khorramdelazad H, Zainodini N, Shabani Z.

    04/5/2014
    CCL11, CCL24, and CCL26 has a role in the recruitment of extravillous trophoblast into decidual tissue and vessels.

    Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26.
    Chau SE, Murthi P, Wong MH, Whitley GS, Brennecke SP, Keogh RJ.

    02/1/2014
    Pregnancy associated environments increased local CCL24/CCR3, supporting the process of decidualization in human early pregnancy.

    Trophoblasts-derived chemokine CCL24 promotes the proliferation, growth and apoptosis of decidual stromal cells in human early pregnancy.
    Li H, Huang YH, Li MQ, Meng YH, Chen X, Shao J, Tang CL, Du MR, Jin LP, Li DJ., Free PMC Article

    12/28/2013
    Phosphodiesterase 4 inhibitors, rolipram and RO-20-1724 have no effect on CCL24 expression in human primary bronchial epithelial cells.

    PDE4 inhibitors have no effect on eotaxin expression in human primary bronchial epithelial cells.
    Paplińska-Goryca M, Chazan R, Grubek-Jaworska H.

    03/9/2013
    The level of eotaxin expression and inflammatory cell count were measured in the material from nasal brushing in healthy controls and in patients with allergic rhinitis, asthma, and chronic obstructive pulmonary disease.

    Expression of eotaxins in the material from nasal brushing in asthma, allergic rhinitis and COPD patients.
    Paplińska M, Hermanowicz-Salamon J, Nejman-Gryz P, Białek-Gosk K, Rubinsztajn R, Arcimowicz M, Placha G, Góra J, Chazan R, Grubek-Jaworska H.

    02/23/2013
    Study shows that CCL24 levels were significantly increased in age-related macular degeneration (AMD) patients despite Avastin treatment as compared with normal controls and those without Avastin.

    New biomarker for neovascular age-related macular degeneration: eotaxin-2.
    Sharma NK, Prabhakar S, Gupta A, Singh R, Gupta PK, Gupta PK, Anand A.

    01/26/2013
    After corticosteroid therapy, the expressions of Eotaxin and Eotaxin-2 in mucosal epithelia of nasal polyps were significantly decreased.

    [Effects of corticosteroid on Eotaxin and Eotaxin-2 in nasal polyps].
    Wang X, Gong S.

    06/18/2011
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