| Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls. | Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
Gilliam-Vigh H, Jorsal T, Nielsen SW, Forman JL, Pedersen J, Poulsen SS, Vilsbøll T, Knop FK. | 11/22/2023 |
| Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes. | Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
Chen L, Wu N, Kennedy L, Francis H, Ceci L, Zhou T, Samala N, Kyritsi K, Wu C, Sybenga A, Ekser B, Dar W, Atkins C, Meadows V, Glaser S, Alpini G., Free PMC Article | 01/15/2022 |
| Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein. | Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O. | 03/20/2021 |
| SCTR hypermethylation is a diagnostic biomarker in colorectal cancer. | SCTR hypermethylation is a diagnostic biomarker in colorectal cancer.
Li D, Zhang L, Fu J, Huang H, Sun S, Zhang D, Zhao L, Ucheojor Onwuka J, Zhao Y, Cui B., Free PMC Article | 01/2/2021 |
| Structure and dynamics of the active Gs-coupled human secretin receptor. | Structure and dynamics of the active Gs-coupled human secretin receptor.
Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ., Free PMC Article | 09/19/2020 |
| High secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis. | Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
Kennedy L, Francis H, Invernizzi P, Venter J, Wu N, Carbone M, Gershwin ME, Bernuzzi F, Franchitto A, Alvaro D, Marzioni M, Onori P, Gaudio E, Sybenga A, Fabris L, Meng F, Glaser S, Alpini G., Free PMC Article | 05/30/2020 |
| elevated in primary sclerosing cholangitis liver samples compared to healthy controls | The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice.
Wu N, Meng F, Invernizzi P, Bernuzzi F, Venter J, Standeford H, Onori P, Marzioni M, Alvaro D, Franchitto A, Gaudio E, Glaser S, Alpini G., Free PMC Article | 08/5/2017 |
| Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. | Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.
Harikumar KG, Augustine ML, Lee LT, Chow BK, Miller LJ., Free PMC Article | 05/7/2017 |
| Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains. | Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.
Dong M, Lam PC, Orry A, Sexton PM, Christopoulos A, Abagyan R, Miller LJ., Free PMC Article | 08/13/2016 |
| Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation. | SCTR regulates cell cycle-related genes toward anti-proliferation in normal breast cells while having pro-proliferation activity in breast cancer cells.
Kang S, Kim B, Kang HS, Jeong G, Bae H, Lee H, Lee S, Kim SJ. | 08/6/2016 |
| High SCTR expression is associated with liver metastases of pancreas neuroendocrine tumors. | Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors.
Sherman SK, Maxwell JE, Carr JC, Wang D, Bellizzi AM, Sue O'Dorisio M, O'Dorisio TM, Howe JR., Free PMC Article | 02/14/2015 |
| Results suggest that Secretin is a potent modulator of adipocyte functions, demonstrating overall a role in enhanced substrate cycling. | Effect of secretin on preadipocyte, differentiating and mature adipocyte functions.
Miegueu P, Cianflone K, Richard D, St-Pierre DH. | 10/19/2013 |
| Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1-mediated transactivation. | Neuron-restrictive silencer factor functions to suppress Sp1-mediated transactivation of human secretin receptor gene.
Yuan Y, Chow BK, Lee VH, Lee LT. | 05/4/2013 |
| Data suggest that the interaction between secretin peptide residue H1 and secretin receptor residue W274 is most compatible with a hydrophobic interaction. | Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.
Dong M, Xu X, Ball AM, Makhoul JA, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ., Free PMC Article | 04/13/2013 |
| binding and activity of a series of 11 truncated and lactam-constrained secretin(5-27) analogues at the prototypic member of this family, the secretin receptor | Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.
Dong M, Te JA, Xu X, Wang J, Pinon DI, Storjohann L, Bordner AJ, Miller LJ., Free PMC Article | 11/12/2011 |
| results demonstrate that secretin and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma | Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.
Onori P, Wise C, Gaudio E, Franchitto A, Francis H, Carpino G, Lee V, Lam I, Miller T, Dostal DE, Glaser SS. | 06/28/2010 |
| Increasing expression of secretin receptor competes for receptor modifying protein 3 (RAMP3) association with calcitonin receptor-like receptor (CLR) to yield a functional adrenomedullin receptor. | Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor.
Harikumar KG, Simms J, Christopoulos G, Sexton PM, Miller LJ., Free PMC Article | 01/21/2010 |
| Data show that Family B G-protein-coupled receptor oligomerization occurs, with many structurally related members, such as the secretin receptor,associating with each other. | Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor.
Harikumar KG, Morfis MM, Sexton PM, Miller LJ., Free PMC Article | 01/21/2010 |
| These results suggest that the secretin receptor can exist only as a structurally-specific homo-dimer, without being present as higher-order oligomers. | Dimerization in the absence of higher-order oligomerization of the G protein-coupled secretin receptor.
Harikumar KG, Happs RM, Miller LJ., Free PMC Article | 01/21/2010 |
| secretin receptors are new markers for bronchopulmonary carcinoid tumors | Wild-type and splice-variant secretin receptors in lung cancer: overexpression in carcinoid tumors and peritumoral lung tissue.
Körner MU, Hayes GM, Carrigan PE, Rehmann R, Miller LJ, Reubi JC. | 01/21/2010 |
| Secretin-receptor and secretin-receptor-variant expressions occur in all gastrinomas | Secretin-receptor and secretin-receptor-variant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results.
Long SH, Berna MJ, Thill M, Pace A, Pradhan TK, Hoffmann KM, Serrano J, Jensen RT., Free PMC Article | 01/21/2010 |
| A novel abnormal spliceoform of the secretin receptor was identified in pancreatic and bile duct cancers and developed as a dual antibody sandwich enzyme-linked immunosorbent assay for measure in the circulation. | A novel secretin receptor splice variant potentially useful for early diagnosis of pancreatic carcinoma.
Hayes GM, Carrigan PE, Dong M, Reubi JC, Miller LJ. | 01/21/2010 |
| Secretin receptor oligomerization occurs through -GxxxG- motif-independent interactions of transmembrane segments during the maturation of nascent molecules. | Secretin receptor oligomers form intracellularly during maturation through receptor core domains.
Lisenbee CS, Miller LJ., Free PMC Article | 01/21/2010 |
| promoter methylation plays a role in the regulation of SR gene expression. | CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.
Pang RT, Lee LT, Ng SS, Yung WH, Chow BK. | 01/21/2010 |
| Secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer of human cerebellum. | Expression and spatial distribution of secretin and secretin receptor in human cerebellum.
Lee SM, Yung WH, Chen L, Chow BK. | 01/21/2010 |