| Association between low-sodium salt intervention and long-term blood pressure changes is modified by ENaC genetic variation: a gene-diet interaction analysis in a randomized controlled trial. | Association between low-sodium salt intervention and long-term blood pressure changes is modified by ENaC genetic variation: a gene-diet interaction analysis in a randomized controlled trial.
Sun H, Zhou Y, Jiang S, Zhao D, Li H, Lu Y, Ma B, Zhou B. | 04/24/2024 |
| Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion. | Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion.
Di X, Hao Y, Duan Z, Ma Y, Cao Y, Tan Z, Song C, Lin X., Free PMC Article | 11/15/2023 |
| A mild and transient form of autosomal recessive pseudohypoaldosteronism type 1 caused by a novel mutation in the SCNN1A gene. | A mild and transient form of autosomal recessive pseudohypoaldosteronism type 1 caused by a novel mutation in the SCNN1A gene.
Efthymiadou A, Gautschi I, van Bemmelen MX, Sertedaki A, Giannakopoulos A, Chrousos G, Schild L, Chrysis D. | 07/6/2023 |
| Rare Variants in Genes Encoding Subunits of the Epithelial Na[+] Channel Are Associated With Blood Pressure and Kidney Function. | Rare Variants in Genes Encoding Subunits of the Epithelial Na(+) Channel Are Associated With Blood Pressure and Kidney Function.
Blobner BM, Kirabo A, Kashlan OB, Sheng S, Arnett DK, Becker LC, Boerwinkle E, Carlson JC, Gao Y, Gibbs RA, He J, Irvin MR, Kardia SLR, Kelly TN, Kooperberg C, McGarvey ST, Menon VK, Montasser ME, Naseri T, Redline S, Reiner AP, Reupena MS, Smith JA, Sun X, Vaidya D, Viaud-Martinez KA, Weeks DE, Yanek LR, Zhu X, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium*, Minster RL, Kleyman TR., Free PMC Article | 01/28/2023 |
| Sodium channel 1 subunit alpha SCNN1A exerts oncogenic function in pancreatic cancer via accelerating cellular growth and metastasis. | Sodium channel 1 subunit alpha SCNN1A exerts oncogenic function in pancreatic cancer via accelerating cellular growth and metastasis.
Gao F, Wang D, Liu X, Wu YH, Wang HT, Sun SL. | 07/30/2022 |
| Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer. | Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer.
Cai C, Zhang Y, Peng X., Free PMC Article | 02/19/2022 |
| Novel SCNN1A gene splicing-site mutation causing autosomal recessive pseudohypoaldosteronism type 1 (PHA1) in two Italian patients belonging to the same small town. | Novel SCNN1A gene splicing-site mutation causing autosomal recessive pseudohypoaldosteronism type 1 (PHA1) in two Italian patients belonging to the same small town.
Serra G, Antona V, D'Alessandro MM, Maggio MC, Verde V, Corsello G., Free PMC Article | 02/12/2022 |
| HOXD9induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelialmesenchymal transformation. | HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation.
Chang J, Hu X, Nan J, Zhang X, Jin X., Free PMC Article | 01/22/2022 |
| Epithelial Sodium Channel and Salt-Sensitive Hypertension. | Epithelial Sodium Channel and Salt-Sensitive Hypertension.
Mutchler SM, Kirabo A, Kleyman TR., Free PMC Article | 09/11/2021 |
| The epithelial sodium channel has a role in breast cancer cell proliferation. | The epithelial sodium channel has a role in breast cancer cell proliferation.
Ware AW, Harris JJ, Slatter TL, Cunliffe HE, McDonald FJ. | 08/14/2021 |
| Cell-specific expression of ENACalpha gene by FOXA1 in the glucocorticoid receptor pathway. | Cell-specific expression of ENACα gene by FOXA1 in the glucocorticoid receptor pathway.
Chung YS, Jin HL, Jeong KW., Free PMC Article | 07/10/2021 |
| DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes. | DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes.
Pierandrei S, Truglio G, Ceci F, Del Porto P, Bruno SM, Castellani S, Conese M, Ascenzioni F, Lucarelli M., Free PMC Article | 05/15/2021 |
| miR95 promotes osteosarcoma growth by targeting SCNN1A. | miR‑95 promotes osteosarcoma growth by targeting SCNN1A.
Geng Y, Zhao S, Jia Y, Xia G, Li H, Fang Z, Zhang Q, Tian R., Free PMC Article | 02/6/2021 |
| MLL2 regulates glucocorticoid receptor-mediated transcription of ENACalpha in human retinal pigment epithelial cells. | MLL2 regulates glucocorticoid receptor-mediated transcription of ENACα in human retinal pigment epithelial cells.
Yang L, Jin M, Jung N, Jeong KW. | 11/21/2020 |
| Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption. | Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption.
Nattramilarasu PK, Bücker R, Lobo de Sá FD, Fromm A, Nagel O, Lee IM, Butkevych E, Mousavi S, Genger C, Kløve S, Heimesaat MM, Bereswill S, Schweiger MR, Nielsen HL, Troeger H, Schulzke JD., Free PMC Article | 10/3/2020 |
| Epithelial Na(+) channel's (ENaC) able to mediate shear force responsiveness relies on the "force-from-filament" principle involving extracellular tethers and the extracellular matrix. Two glycosylated asparagines, respectively their N-glycans localized in the palm and knuckle domains of alphaENaC, were identified as potential tethers. Endothelial-specific overexpression of alphaENaC in mice induced hypertension. | Shear force sensing of epithelial Na(+) channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC.
Knoepp F, Ashley Z, Barth D, Baldin JP, Jennings M, Kazantseva M, Saw EL, Katare R, Alvarez de la Rosa D, Weissmann N, Fronius M., Free PMC Article | 05/9/2020 |
| SCNN1A silence remarkably blocked SK-OV-3 cell growth ability, migration, and invasion potential. Western blotting results showed that SCNN1A silence led to an increase in E-cadherin, whereas a decrease in N-cadherin, Vimentin, and Snail in SK-OV-3 cells. | Upregulation of SCNN1A Promotes Cell Proliferation, Migration, and Predicts Poor Prognosis in Ovarian Cancer Through Regulating Epithelial-Mesenchymal Transformation.
Wu L, Ling ZH, Wang H, Wang XY, Gui J. | 04/11/2020 |
| Newborns born via elective cesarean section exhibited a lower expression of ENaC, Na-K-ATPase, and SGK1. Significant correlations existed between the expressions of ENaC, Na-K-ATPase, and SGK1, and the concentration of norepinephrine in the cord blood, which points to the importance of birth stress in promoting lung fluid clearance during early postnatal pulmonary adaptation. | Postnatal gene expression of airway epithelial sodium transporters associated with birth stress in humans.
Süvari L, Janér C, Helve O, Kaskinen A, Turpeinen U, Pitkänen-Argillander O, Andersson S. | 03/7/2020 |
| Mutation in the SCNN1A gene is associated with pseudohypoaldosteronism type 1. | Phenotypic diversity and correlation with the genotypes of pseudohypoaldosteronism type 1.
Gopal-Kothandapani JS, Doshi AB, Smith K, Christian M, Mushtaq T, Banerjee I, Padidela R, Ramakrishnan R, Owen C, Cheetham T, Dimitri P. | 02/15/2020 |
| Systemic Pseudohypoaldosteronism Type 1 due to 3 Novel Mutations in SCNN1Aand SCNN1BGenes. | Systemic Pseudohypoaldosteronism Type 1 due to 3 Novel Mutations in SCNN1Aand SCNN1BGenes.
Cayir A, Demirelli Y, Yildiz D, Kahveci H, Yarali O, Kurnaz E, Vuralli D, Demirbilek H. | 12/21/2019 |
| In single-marker analyses, 3 independent common variants in SCNN1A, rs11614164, rs4764586, and rs3741914, associated with Blood Pressure Salt Sensitivity after Bonferroni correction. | Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.
Gu X, Gu D, He J, Rao DC, Hixson JE, Chen J, Li J, Huang J, Wu X, Rice TK, Shimmin LC, Kelly TN., Free PMC Article | 11/9/2019 |
| The features described for neutrophils from hypertensive patients could be attributed to alpha-ENaC overexpression. | Enhanced expression of the Epithelial Sodium Channel in neutrophils from hypertensive patients.
Reus-Chavarría E, Martínez-Vieyra I, Salinas-Nolasco C, Chávez-Piña AE, Méndez-Méndez JV, López-Villegas EO, Sosa-Peinado A, Cerecedo D. | 09/21/2019 |
| Here, we present the structure of human ENaC in the uncleaved state determined by single-particle cryo-electron microscopy. The ion channel is composed of a large extracellular domain and a narrow transmembrane domain | Structure of the human epithelial sodium channel by cryo-electron microscopy.
Noreng S, Bharadwaj A, Posert R, Yoshioka C, Baconguis I., Free PMC Article | 02/2/2019 |
| Proteolytic cleavage activates epithelial sodium channel (SCNN) by removal of specific segments in finger domains of alpha and gamma subunits. Data suggest that the lower "palm" domain of SCNN1A is essential for allosteric activation of the SCNN heterotetramer [SCNN1A(1)-SCNN1B-SCNN1A(2)-SCNN1G]. | Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel.
Shobair M, Popov KI, Dang YL, He H, Stutts MJ, Dokholyan NV., Free PMC Article | 01/16/2019 |
| In the present study, the SCNN1G gene was associated with 24-h urinary sodium excretion but was not related to blood pressure. The SCNN1A and SCNN1B genes were not associated with blood pressure either. | Association of Genetic Variation in the Epithelial Sodium Channel Gene with Urinary Sodium Excretion and Blood Pressure.
Yang YJ, Kim J, Kwock CK., Free PMC Article | 11/3/2018 |