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    SCD stearoyl-CoA desaturase [ Homo sapiens (human) ]

    Gene ID: 6319, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Effect of stearoyl-coenzyme a desaturase 1 (SCD1) on the function of mast cells.

    Effect of stearoyl-coenzyme a desaturase 1 (SCD1) on the function of mast cells.
    Zhang X, Li A, Zhu Y, Liu F, Zhao D, Tang H, Xu C.

    11/5/2024
    Severity Ranking of Missense and Frameshift Genetic Variants in SCD1 by In Silico and In Vitro Functional Analysis.

    Severity Ranking of Missense and Frameshift Genetic Variants in SCD1 by In Silico and In Vitro Functional Analysis.
    Susán HK, Orosz G, Zámbó V, Csala M, Kereszturi É., Free PMC Article

    10/25/2024
    Death and the desaturase: Implication of Stearoyl-CoA desaturase-1 in the mechanisms of cell stress, apoptosis, and ferroptosis.

    Death and the desaturase: Implication of Stearoyl-CoA desaturase-1 in the mechanisms of cell stress, apoptosis, and ferroptosis.
    Igal RA.

    09/23/2024
    Lactate drives the ESM1-SCD1 axis to inhibit the antitumor CD8[+] T-cell response by activating the Wnt/beta-catenin pathway in ovarian cancer cells and inducing cisplatin resistance.

    Lactate drives the ESM1-SCD1 axis to inhibit the antitumor CD8(+) T-cell response by activating the Wnt/β-catenin pathway in ovarian cancer cells and inducing cisplatin resistance.
    Fan Z, Ye M, Liu D, Zhou W, Zeng T, He S, Li Y.

    08/5/2024
    Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase.

    Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase.
    Guan X, Wang Y, Yu W, Wei Y, Lu Y, Dai E, Dong X, Zhao B, Hu C, Yuan L, Luan X, Miao K, Chen B, Cheng XD, Zhang W, Qin JJ., Free PMC Article

    07/31/2024
    Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer.

    Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer.
    Liu Y, Wang Y, Hao S, Qin Y, Wu Y.

    07/26/2024
    FADS2 confers SCD1 inhibition resistance to cancer cells by modulating the ER stress response.

    FADS2 confers SCD1 inhibition resistance to cancer cells by modulating the ER stress response.
    Ikeda T, Katoh Y, Hino H, Seta D, Ogawa T, Iwata T, Nishio H, Sugawara M, Hirai S., Free PMC Article

    06/17/2024
    Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer.

    Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer.
    Huang F, Zhao N, Cai P, Hou M, Yang S, Zheng B, Ma Q, Jiang J, Gai X, Mao Y, Wang L, Hu Z, Zha X, Liu F, Zhang H.

    05/13/2024
    [Expression of SCD1 in TFE3-rRCC and its effect on proliferation and migration].

    [Expression of SCD1 in TFE3-rRCC and its effect on proliferation and migration].
    Dong YH, Liuxu WT, Chen Y, Gan WD, Li DM.

    04/18/2024
    Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma.

    Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma.
    Shirahama H, Tani Y, Tsukahara S, Okamoto Y, Hasebe A, Noda T, Ando S, Ushijima M, Matsuura M, Tomida A.

    04/17/2024
    Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells.

    Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells.
    Lee J, Jang S, Im J, Han Y, Kim S, Jo H, Wang W, Cho U, Kim SI, Seol A, Kim B, Song YS., Free PMC Article

    04/5/2024
    Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1-mediated lipid metabolism.

    Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1-mediated lipid metabolism.
    Che G, Wang W, Wang J, He C, Yin J, Chen Z, He C, Wang X, Yang Y, Liu J., Free PMC Article

    02/29/2024
    IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD.

    IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD.
    Han C, Hu C, Liu T, Sun Y, Hu F, He Y, Zhang J, Chen J, Ding J, Fan J, Zhang X, Wang J, Qiao X, Jiang D, Yang K, Yang S., Free PMC Article

    02/21/2024
    Identification and experimental validation of Stearoyl-CoA desaturase is a new drug therapeutic target for osteosarcoma.

    Identification and experimental validation of Stearoyl-CoA desaturase is a new drug therapeutic target for osteosarcoma.
    Nie J, He C, Shu Z, Liu N, Zhong Y, Long X, Liu J, Yang F, Liu Z, Huang P.

    01/26/2024
    Allele-specific effect of various dietary fatty acids and ETS1 transcription factor on SCD1 expression.

    Allele-specific effect of various dietary fatty acids and ETS1 transcription factor on SCD1 expression.
    Tibori K, Zámbó V, Orosz G, Szelényi P, Sarnyai F, Tamási V, Rónai Z, Csala M, Kereszturi É., Free PMC Article

    01/9/2024
    Stearoyl-CoA desaturase 1 inhibition impairs triacylglycerol accumulation and lipid droplet formation in colorectal cancer cells.

    Stearoyl-CoA desaturase 1 inhibition impairs triacylglycerol accumulation and lipid droplet formation in colorectal cancer cells.
    Tracz-Gaszewska Z, Sowka A, Dobrzyn P.

    12/18/2023
    SCD1 inhibits HBV replication by regulating autophagy under high lipid conditions.

    SCD1 inhibits HBV replication by regulating autophagy under high lipid conditions.
    Du X, Shi X, Han M, Gao X, Wang C, Jiang C, Pu C.

    11/27/2023
    Deltex E3 ubiquitin ligase 4 promotes thyroid cancer progression through stearoyl-CoA desaturase 1.

    Deltex E3 ubiquitin ligase 4 promotes thyroid cancer progression through stearoyl-CoA desaturase 1.
    Cui Y, Luo J, Bai N, Yu Z.

    08/25/2023
    ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer.

    ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer.
    Wong TL, Loh JJ, Lu S, Yan HHN, Siu HC, Xi R, Chan D, Kam MJF, Zhou L, Tong M, Copland JA, Chen L, Yun JP, Leung SY, Ma S., Free PMC Article

    05/30/2023
    Stearoyl coenzyme A desaturase-1: multitasker in cancer, metabolism, and ferroptosis.

    Stearoyl coenzyme A desaturase-1: multitasker in cancer, metabolism, and ferroptosis.
    Sen U, Coleman C, Sen T.

    05/19/2023
    HOXB9 a miR-122-5p regulated gene, suppressed the anticancer effects of brusatol by upregulating SCD1 expression in melanoma.

    HOXB9 a miR-122-5p regulated gene, suppressed the anticancer effects of brusatol by upregulating SCD1 expression in melanoma.
    Guo Z, Li N, Jiang Y, Zhang L, Tong L, Wang Y, Lv P, Li X, Han C, Lin J.

    05/19/2023
    PROX1 restrains ferroptosis via SCD transcription activation in colorectal cancer.

    PROX1 restrains ferroptosis via SCD transcription activation in colorectal cancer.
    Zhang R, Luo D, Shan Z, Yang Y, Qin Y, Li Q, Li X., Free PMC Article

    05/17/2023
    Stearoyl-CoA Desaturases1 Accelerates Non-Small Cell Lung Cancer Metastasis by Promoting Aromatase Expression to Improve Estrogen Synthesis.

    Stearoyl-CoA Desaturases1 Accelerates Non-Small Cell Lung Cancer Metastasis by Promoting Aromatase Expression to Improve Estrogen Synthesis.
    Chen J, Wang Y, Meng W, Zhao R, Lin W, Xiao H, Liao Y., Free PMC Article

    04/17/2023
    RUNX2 interacts with SCD1 and activates Wnt/beta-catenin signaling pathway to promote the progression of clear cell renal cell carcinoma.

    RUNX2 interacts with SCD1 and activates Wnt/β-catenin signaling pathway to promote the progression of clear cell renal cell carcinoma.
    Song X, Liu J, Liu B, Piao C, Kong C, Li Z., Free PMC Article

    03/23/2023
    SNORD88C guided 2'-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer.

    SNORD88C guided 2'-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer.
    Wang K, Wang S, Zhang Y, Xie L, Song X, Song X., Free PMC Article

    02/28/2023
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