| RREB1 could act as an immunological and prognostic biomarker: From comprehensive analysis to osteosarcoma validation. | RREB1 could act as an immunological and prognostic biomarker: From comprehensive analysis to osteosarcoma validation.
Zhang Z, Liu B, Mei L, Chen R, Zhou H, Li Z. | 11/7/2024 |
| A novel interaction between RNA m[6]A methyltransferase METTL3 and RREB1. | A novel interaction between RNA m(6)A methyltransferase METTL3 and RREB1.
Xu J, Sivakumar C, Ryan CW, Rao RC. | 10/16/2024 |
| LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network. | LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network.
Dong Q, Qiu H, Piao C, Li Z, Cui X., Free PMC Article | 08/28/2023 |
| Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. | Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.
Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, Yu GZ, Mahajan A, Larsson A, MacDonald PE, Davies B, den Hoed M, Gloyn AL., Free PMC Article | 03/16/2023 |
| The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-beta pathway. | The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-β pathway.
Li H, Jiang Y, Hu J, Xu J, Chen L, Zhang G, Zhao J, Zong S, Guo Z, Li X, Zhao X, Jing Z., Free PMC Article | 01/21/2023 |
| RREB1 promotes the development of parafollicular carcinogenesis through the Ras-Raf-1-ELK3 signaling pathway. | RREB1 promotes the development of parafollicular carcinogenesis through the Ras-Raf-1-ELK3 signaling pathway.
Ma S, Wang H, Li W, Yan Z, Luo X, Lu P. | 10/1/2022 |
| Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer. | Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer.
Gao Q, Wu Y, Lu C, Kai W, Xie W, Wang Q, Wang L, Liu S, Pan Y., Free PMC Article | 04/16/2022 |
| Transcription Factor RREB1: from Target Genes towards Biological Functions. | Transcription Factor RREB1: from Target Genes towards Biological Functions.
Deng YN, Xia Z, Zhang P, Ejaz S, Liang S., Free PMC Article | 10/2/2021 |
| Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes. | Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes.
Kent OA, Saha M, Coyaud E, Burston HE, Law N, Dadson K, Chen S, Laurent EM, St-Germain J, Sun RX, Matsumoto Y, Cowen J, Montgomery-Song A, Brown KR, Ishak C, Rose J, De Carvalho DD, He HH, Raught B, Billia F, Kannu P, Rottapel R., Free PMC Article | 10/3/2020 |
| Data show that RREB1-induced upregulation of AGAP2-AS1 regulates cell proliferation and migration in PC partly through suppressing ANKRD1 and ANGPTL4 by recruiting EZH2. | RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4.
Hui B, Ji H, Xu Y, Wang J, Ma Z, Zhang C, Wang K, Zhou Y., Free PMC Article | 06/6/2020 |
| identification of RAS-responsive element binding protein 1 (RREB1), a RAS transcriptional effector, as a key partner of TGF-beta-activated SMAD transcription factors in epithelial-to-mesenchymal transitions | TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1.
Su J, Morgani SM, David CJ, Wang Q, Er EE, Huang YH, Basnet H, Zou Y, Shu W, Soni RK, Hendrickson RC, Hadjantonakis AK, Massagué J., Free PMC Article | 05/9/2020 |
| Findings demonstrated that RREB1 blocks granulocytic differentiation of myeloid leukemia cells by inhibiting the expression of miR-145 and downstream targets of the RAS signal pathway. | RAS-Responsive Element-Binding Protein 1 Blocks the Granulocytic Differentiation of Myeloid Leukemia Cells.
Yao J, Zhong L, Zhong P, Liu D, Yuan Z, Liu J, Yao S, Zhao Y, Chen M, Li L, Liu L, Liu B., Free PMC Article | 02/22/2020 |
| Functional data indicate that modulating Ras-responsive element-binding protein 1 (RREB1) expression in human DLBCL cell lines in vitro alters KRAS expression, signaling, and proliferation; thus, suggesting that this proto-oncogene is a common mechanism of RAS/MAPK hyperactivation in human DLBCL. | Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.
Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA. | 02/1/2020 |
| Ectomesenchymal chondromyxoid tumors are characterized by an RREB1-MKL2 fusion gene. | Ectomesenchymal Chondromyxoid Tumor: A Neoplasm Characterized by Recurrent RREB1-MKL2 Fusions.
Dickson BC, Antonescu CR, Argyris PP, Bilodeau EA, Bullock MJ, Freedman PD, Gnepp DR, Jordan RC, Koutlas IG, Lee CH, Leong I, Merzianu M, Purgina BM, Thompson LDR, Wehrli B, Wright JM, Swanson D, Zhang L, Bishop JA., Free PMC Article | 09/7/2019 |
| Of the 465,447 CpG sites analyzed, 12 showed differential methylation (false discovery rate <0.15), including markers within genes associated with monogenic diabetes (HNF4A) or obesity (RREB1). The overall methylation at HNF4A showed inverse correlations with mRNA expression levels, though non significant | DNA methylation profiles in sibling pairs discordant for intrauterine exposure to maternal gestational diabetes.
Kim E, Kwak SH, Chung HR, Ohn JH, Bae JH, Choi SH, Park KS, Hong JS, Sung J, Jang HC., Free PMC Article | 10/27/2018 |
| RREB1 cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM) of the intervertebral disc. | The noncoding RNA linc-ADAMTS5 cooperates with RREB1 to protect from intervertebral disc degeneration through inhibiting ADAMTS5 expression.
Wang K, Song Y, Liu W, Wu X, Zhang Y, Li S, Kang L, Tu J, Zhao K, Hua W, Yang C. | 07/29/2017 |
| RREB1 and CCND1 gains are common in nail apparatus melanoma | Malignant Melanoma of the Nail Apparatus: A Fluorescence In Situ Hybridization Analysis of 7 Cases.
Romano RC, Shon W, Sukov WR. | 04/22/2017 |
| Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. | Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome.
Guo T, Chung JH, Wang T, McDonald-McGinn DM, Kates WR, Hawuła W, Coleman K, Zackai E, Emanuel BS, Morrow BE., Free PMC Article | 03/26/2016 |
| RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. | The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease.
Bonomo JA, Guan M, Ng MC, Palmer ND, Hicks PJ, Keaton JM, Lea JP, Langefeld CD, Freedman BI, Bowden DW., Free PMC Article | 07/25/2015 |
| The pathway of RREB1/ZIP3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma. | The cytotoxic role of RREB1, ZIP3 zinc transporter, and zinc in human pancreatic adenocarcinoma.
Franklin RB, Zou J, Costello LC., Free PMC Article | 04/11/2015 |
| RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. | hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1).
Zou J, Milon BC, Desouki MM, Costello LC, Franklin RB., Free PMC Article | 01/10/2015 |
| Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control | Drosophila Hindsight and mammalian RREB-1 are evolutionarily conserved DNA-binding transcriptional attenuators.
Ming L, Wilk R, Reed BH, Lipshitz HD. | 12/20/2014 |
| Data show the transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level. | Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice.
Yamane T, Suzui S, Kitaura H, Takahashi-Niki K, Iguchi-Ariga SM, Ariga H., Free PMC Article | 08/9/2014 |
| RREB1 is overexpressed in colorectal adenocarcinoma tumors. RREB1 repressed miR-143/145 modulates KRAS signaling. | RREB1 repressed miR-143/145 modulates KRAS signaling through downregulation of multiple targets.
Kent OA, Fox-Talbot K, Halushka MK., Free PMC Article | 07/20/2013 |
| These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3, which results in decreased zinc in pancreatic premalignant and carcinoma cells | Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma.
Costello LC, Zou J, Desouki MM, Franklin RB., Free PMC Article | 06/22/2013 |