| CSB and SMARCAL1 compete for RPA32 at stalled forks and differentially control the fate of stalled forks in BRCA2-deficient cells. | CSB and SMARCAL1 compete for RPA32 at stalled forks and differentially control the fate of stalled forks in BRCA2-deficient cells.
Batenburg NL, Sowa DJ, Walker JR, Andres SN, Zhu XD., Free PMC Article | 06/10/2024 |
| Mechanism of single-stranded DNA annealing by RAD52-RPA complex. | Mechanism of single-stranded DNA annealing by RAD52-RPA complex.
Liang CC, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC., Free PMC Article | 06/6/2024 |
| Upregulated RPA2 in endometrial tissues of repeated implantation failure patients impairs the endometrial decidualization. | Upregulated RPA2 in endometrial tissues of repeated implantation failure patients impairs the endometrial decidualization.
Zhao H, Lv N, Cong J, Chen G, Bao H, Liu X., Free PMC Article | 11/18/2023 |
| hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage. | hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage.
Boucher D, Kariawasam R, Burgess J, Gimenez A, Ocampo TE, Ferguson B, Naqi A, Walker GJ, Bolderson E, Gamsjaeger R, O'Byrne KJ, Cubeddu L, Khanna KK, Richard DJ., Free PMC Article | 01/29/2022 |
| RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork. | RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork.
Kavli B, Iveland TS, Buchinger E, Hagen L, Liabakk NB, Aas PA, Obermann TS, Aachmann FL, Slupphaug G., Free PMC Article | 05/15/2021 |
| Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair. | Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair.
Caldwell CC, Spies M., Free PMC Article | 03/13/2021 |
| HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation. | HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation.
Lai Y, Zhu M, Wu W, Rokutanda N, Togashi Y, Liang W, Ohta T., Free PMC Article | 11/21/2020 |
| RPA, best known for its role in DNA replication and repair, recruits HIRA to promoters and enhancers and regulates deposition of newly synthesized H3.3 to these regulatory elements for gene regulation. | RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.
Zhang H, Gan H, Wang Z, Lee JH, Zhou H, Ordog T, Wold MS, Ljungman M, Zhang Z., Free PMC Article | 10/7/2017 |
| E3 ligase RFWD3 functions in timely removal and degradation of RPA and RAD51 to allow homologous recombination progression to subsequent steps following mitomycin C damage. | RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination.
Inano S, Sato K, Katsuki Y, Kobayashi W, Tanaka H, Nakajima K, Nakada S, Miyoshi H, Knies K, Takaori-Kondo A, Schindler D, Ishiai M, Kurumizaka H, Takata M. | 09/23/2017 |
| Single point mutations in the RPA32 subunit of RPA that abolish interaction with RFWD3 also inhibit interstrand crossling repair, demonstrating that RPA-mediated RFWD3 recruitment to stalled replication forks is important for ICL repair. | RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.
Feeney L, Muñoz IM, Lachaud C, Toth R, Appleton PL, Schindler D, Rouse J., Free PMC Article | 09/23/2017 |
| knockdown of RPA2 promoted formation of the menin-p65 complex and repressed the expression of NF-kappaB-mediated genes. RPA2 expression was induced via an E2F1-dependent mechanism in MCF7 and MDA-MB-231 cells treated with NF-kappaB activators, TNF-alpha or lipopolysaccharide (LPS). | Upregulation of RPA2 promotes NF-κB activation in breast cancer by relieving the antagonistic function of menin on NF-κB-regulated transcription.
Chen CC, Juan CW, Chen KY, Chang YC, Lee JC, Chang MC. | 09/2/2017 |
| The authors show that Vpr can form a trimolecular complex with UNG2 and RPA32 and the positive effect of UNG2 and RPA32 on the reverse transcription process leading to optimal virus replication and dissemination between the primary target cells of HIV-1. | Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination.
Herate C, Vigne C, Guenzel CA, Lambele M, Rouyez MC, Benichou S., Free PMC Article | 10/22/2016 |
| RPA32 phosphorylation regulates replication arrest, recombination, late origin firing, and mitotic catastrophe | DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.
Ashley AK, Shrivastav M, Nie J, Amerin C, Troksa K, Glanzer JG, Liu S, Opiyo SO, Dimitrova DD, Le P, Sishc B, Bailey SM, Oakley GG, Nickoloff JA., Free PMC Article | 04/25/2015 |
| Expression of mutant RPA2 or loss of PALB2 expression led to significant DNA damage after replication stress, a defect accentuated by poly-ADP (adenosine diphosphate) ribose polymerase inhibitors. | Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery.
Murphy AK, Fitzgerald M, Ro T, Kim JH, Rabinowitsch AI, Chowdhury D, Schildkraut CL, Borowiec JA., Free PMC Article | 11/22/2014 |
| Conserved motifs are required for RPA32 binding the the N-terminus of SMARCAL1. | Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins.
Xie S, Lu Y, Jakoncic J, Sun H, Xia J, Qian C. | 09/27/2014 |
| study reports the characterization of the RPA32C-SMARCAL1 interface at the molecular level; implications of results are discussed with respect to the recruitment of SMARCAL1 and other DNA damage response and repair proteins to stalled replication forks | Structural analysis of replication protein A recruitment of the DNA damage response protein SMARCAL1.
Feldkamp MD, Mason AC, Eichman BF, Chazin WJ., Free PMC Article | 07/12/2014 |
| study concludes RPA2 expression is translationally regulated via internal ribosome entry site and by eIF3a and that this regulation is partly accountable for cellular response to DNA damage and survival. | Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a.
Yin JY, Dong ZZ, Liu RY, Chen J, Liu ZQ, Zhang JT., Free PMC Article | 08/3/2013 |
| this study has explored the role of RPA32 phosphorylation at CDK and ATR sites and propose that phosphorylation of the RPA32 subunit is dispensable for checkpoint activation induced by replication stress with aphidicolin. | Implication of RPA32 phosphorylation in S-phase checkpoint signalling at replication forks stalled with aphidicolin in Xenopus egg extracts.
Recolin B, Maiorano D. | 03/30/2013 |
| 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2 | 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.
Chen CC, Lee JC, Chang MC. | 10/13/2012 |
| Data show that the R88C variant impairs binding of the R88C variant impairs binding of uracil-DNA glycosylase UNG2 to replication protein A RPA2. | The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
Torseth K, Doseth B, Hagen L, Olaisen C, Liabakk NB, Græsmann H, Durandy A, Otterlei M, Krokan HE, Kavli B, Slupphaug G. | 09/29/2012 |
| Replication protein A1, replication protein A2, and cyclins D2 and D3 seem to have a parallel role in the promotion of cell cycle in astrocytic tumors being implicated in the malignant progression of these neoplasms. | Replication protein A: a reliable biologic marker of prognostic and therapeutic value in human astrocytic tumors.
Kanakis D, Levidou G, Gakiopoulou H, Eftichiadis C, Thymara I, Fragkou P, Trigka EA, Boviatsis E, Patsouris E, Korkolopoulou P. | 11/12/2011 |
| RPA1 and RPA2 overexpression seems to be more important during early T-categories of bladder carcinogenesis, showing similar kinetics with cyclin D1 | Prognostic significance of replication protein A (RPA) expression levels in bladder urothelial carcinoma.
Levidou G, Gakiopoulou H, Kavantzas N, Saetta AA, Karlou M, Pavlopoulos P, Thymara I, Diamantopoulou K, Patsouris E, Korkolopoulou P. | 11/5/2011 |
| RPA2 hyperphosphorylation by DNA-PK in response to DNA double-strand breaks blocks unscheduled homologous recombination and delays mitotic entry. | DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange.
Liaw H, Lee D, Myung K., Free PMC Article | 11/5/2011 |
| RPA2 up-regulation may be involved in the growth and/or survival of BRCA1 tumor cells and useful in immunohistochemical discrimination of triple-negative BRCA1 tumors. | Proteomic analysis of BRCA1-depleted cell line reveals a putative role for replication protein A2 up-regulation in BRCA1 breast tumor development.
Bouley J, Pionneau C, Varinot J, Biard D, Genestie C, Antoine M, Coulet F, Stern MH, Stoppa-Lyonnet D, Soubrier F. | 05/14/2011 |
| At the subunit level, 13 proteins out of 30 examined may interact with RPA2. | Identification of proteins that may directly interact with human RPA.
Nakaya R, Takaya J, Onuki T, Moritani M, Nozaki N, Ishimi Y. | 02/26/2011 |