| Nuclear p62 condensates stabilize the promyelocytic leukemia nuclear bodies by sequestering their ubiquitin ligase RNF4. | Nuclear p62 condensates stabilize the promyelocytic leukemia nuclear bodies by sequestering their ubiquitin ligase RNF4.
Fu A, Luo Z, Ziv T, Bi X, Lulu-Shimron C, Cohen-Kaplan V, Ciechanover A., | 10/28/2024 |
| RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication. | RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication.
Her J, Zheng H, Bunting SF., Free PMC Article | 06/3/2024 |
| RNF4 prevents genomic instability caused by chronic DNA under-replication. | RNF4 prevents genomic instability caused by chronic DNA under-replication.
Oram MK, Baxley RM, Simon EM, Lin K, Chang YC, Wang L, Myers CL, Bielinsky AK., | 03/5/2024 |
| RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival. | RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.
Novak R, Ahmad YA, Timaner M, Bitman-Lotan E, Oknin-Vaisman A, Horwitz R, Hartmann O, Reissland M, Buck V, Rosenfeldt M, Nikomarov D, Diefenbacher ME, Shaked Y, Orian A., Free PMC Article | 10/15/2022 |
| RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus. | RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus.
Huang J, Yang W, Jiang K, Liu Y, Tan X, Luo J. | 09/10/2022 |
| PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARalpha. | PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As(2)O(3) by stabilizing oncoprotein PML-RARα.
Huang X, Yang Y, Zhu D, Zhao Y, Wei M, Li K, Zhu HH, Zheng X., Free PMC Article | 06/18/2022 |
| RNF4 silencing induces cell growth arrest and DNA damage by promoting nuclear targeting of p62 in hepatocellular carcinoma. | RNF4 silencing induces cell growth arrest and DNA damage by promoting nuclear targeting of p62 in hepatocellular carcinoma.
Lv B, Pan Y, Hou D, Chen P, Zhang J, Chu Y, Li M, Zeng Y, Yang D, Liu J. | 04/30/2022 |
| Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination. | Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.
Han MM, Hirakawa M, Yamauchi M, Matsuda N. | 02/12/2022 |
| Knockdown of endogenous RNF4 exacerbates ischaemia-induced cardiomyocyte apoptosis in mice. | Knockdown of endogenous RNF4 exacerbates ischaemia-induced cardiomyocyte apoptosis in mice.
Qiu F, Han Y, Shao X, Paulo P, Li W, Zhu M, Tang N, Guo S, Chen Y, Wu H, Zhao D, Liu Y, Chu W., Free PMC Article | 05/8/2021 |
| Regulation of eIF2alpha by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance. | Regulation of eIF2α by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance.
Avitan-Hersh E, Feng Y, Oknin Vaisman A, Abu Ahmad Y, Zohar Y, Zhang T, Lee JS, Lazar I, Sheikh Khalil S, Feiler Y, Kluger H, Kahana C, Brown K, Ruppin E, Ronai ZA, Orian A., Free PMC Article | 04/3/2021 |
| RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression. | RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.
Nishida T, Yamada Y. | 11/28/2020 |
| Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection. | Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection.
Jan Fada B, Kaadi E, Samrat SK, Zheng Y, Gu H., Free PMC Article | 11/21/2020 |
| Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer. | Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer.
Murphy P, Xu Y, Rouse SL, Jaffray EG, Plechanovová A, Matthews SJ, Carlos Penedo J, Hay RT., Free PMC Article | 09/12/2020 |
| Designing active RNF4 monomers by introducing a tryptophan: avidity towards E2 approximately Ub conjugates dictates the activity of ubiquitin RING E3 ligases. | Designing active RNF4 monomers by introducing a tryptophan: avidity towards E2∼Ub conjugates dictates the activity of ubiquitin RING E3 ligases.
Sarkar S, Behera AP, Borar P, Banka PA, Datta AB. | 02/15/2020 |
| the SUMO pathway contributes to the clearance of aggregated ATXN7 and suggest that its deregulation might be associated with SCA7 disease progression. | SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models.
Marinello M, Werner A, Giannone M, Tahiri K, Alves S, Tesson C, den Dunnen W, Seeler JS, Brice A, Sittler A., Free PMC Article | 08/3/2019 |
| Taken together, these data demonstrate that the protein kinase activity and levels of PIM1 can be regulated by a covalent post-translational modification via RNF4. | A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity.
Iyer RS, Chatham L, Sleigh R, Meek DW., Free PMC Article | 06/8/2019 |
| DNMT1 as a potential new small ubiquitin-related modifier-(SUMO)-targeted ubiquitin E3 ligase substrate of RNF4, with knockdown of dnmt1 largely restoring primitive and definitive granulopoiesis in rnf4-deficient zebrafish | RNF4 regulates zebrafish granulopoiesis through the DNMT1-C/EBPα axis.
Wang L, Liu X, Wang H, Yuan H, Chen S, Chen Z, de The H, Zhou J, Zhu J. | 03/23/2019 |
| Study provides an insight into the role of the RNF4 to balance the role of SUMO signaling by directly targeting Ubc9 and SUMO E3 ligases. | The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.
Kumar R, González-Prieto R, Xiao Z, Verlaan-de Vries M, Vertegaal ACO., Free PMC Article | 09/22/2018 |
| High RNF4 expression is associated with adenovirus infections. | E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression.
Müncheberg S, Hay RT, Ip WH, Meyer T, Weiß C, Brenke J, Masser S, Hadian K, Dobner T, Schreiner S., Free PMC Article | 08/4/2018 |
| Respiratory syncytial virus induces NRF2 degradation through a PML-RNF4 pathway. | Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein - ring finger protein 4 dependent pathway.
Komaravelli N, Ansar M, Garofalo RP, Casola A., Free PMC Article | 07/7/2018 |
| Thus, although Rnf4 and Ube2w functionally interact in vitro, these genetic experiments indicate that in response to DNA damage Ube2w and Rnf4 function in distinct pathways. | Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage.
Maure JF, Moser SC, Jaffray EG, F Alpi A, Hay RT., Free PMC Article | 04/7/2018 |
| The E3 ligase RNF4 is required to ubiquitinate FXR in response to SUMOylation. | A CK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR.
Bilodeau S, Caron V, Gagnon J, Kuftedjian A, Tremblay A., Free PMC Article | 04/7/2018 |
| RNF4-dependent ubiquitylation translates transient phosphorylation signal(s) into long-term protein stabilization, resulting in enhanced oncoprotein activation | RNF4-Dependent Oncogene Activation by Protein Stabilization.
Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilagan MXG, Benhamou D, Dittmar G, Kopan R, Birchmeier W, Schwartz AL, Orian A., Free PMC Article | 02/10/2018 |
| These findings indicate that SUMOylation of NDRG2 is necessary for its tumor suppressor function in lung adenocarcinoma and that RNF4 increases the efficiency of this process. | RNF4-mediated SUMOylation is essential for NDRG2 suppression of lung adenocarcinoma.
Tantai J, Pan X, Hu D., Free PMC Article | 01/6/2018 |
| post-translational modification of Nkx3.2 employing HDAC9-PIASy-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates. | A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability.
Choi HJ, Kwon S, Kim DW. | 12/2/2017 |