| The data suggest that microtubule acetylation upregulates KL1 and induces more aneuploidy if tau is deficient. | Microtubule Hyperacetylation Enhances KL1-Dependent Micronucleation under a Tau Deficiency in Mammary Epithelial Cells.
Sudo H., Free PMC Article | 12/22/2018 |
| the SCF/c-KIT system is aberrantly expressed in varicocele(VC) testis, which could be involved in male infertility caused by VC. | Aberrant expressions of stem cell factor/c-KIT in rat testis with varicocele.
Qin Q, Liu J, Ma Y, Wang Y, Zhang F, Gao S, Dong L. | 06/9/2018 |
| It was concluded that the exposure of cadimium on newborn rats ovaries could inhibit follicle development. SCF/c-kit system might mediate follicle development damage caused by cadmium, which is associated with DNA hypomethylation of SCF/c-kit promoter region may be worthy of further study. | Cadmium exposure in newborn rats ovary induces developmental disorders of primordial follicles and the differential expression of SCF/c-kit gene.
Zhang W, Wu T, Zhang C, Luo L, Xie M, Huang H. | 10/21/2017 |
| MGF-C25E promotes tenocyte migration by increasing nuclear stiffness via the FAK-ERK1/2 signaling pathway. | Increased nuclear stiffness via FAK-ERK1/2 signaling is necessary for synthetic mechano-growth factor E peptide-induced tenocyte migration.
Zhang B, Luo Q, Chen Z, Shi Y, Ju Y, Yang L, Song G., Free PMC Article | 12/17/2016 |
| up-regulation of the NPs/NPR-C and NPs/NPR-A, B/cGMP signaling pathways may be involved in depression-induced loss of gastric ICC by decreasing the production of mSCF | NPs/NPRs Signaling Pathways May Be Involved in Depression-Induced Loss of Gastric ICC by Decreasing the Production of mSCF.
Lin XL, Tang XD, Cai ZX, Wang FY, Li P, Sui H, Guo HS., Free PMC Article | 07/30/2016 |
| Downregulation of either c-kit or CXCR4 in bone marrow stem cells decreased engraftment of circulating bone marrow stem cells and inhibited reparative effects of transmyocardial revascularization. | Transmyocardial Revascularization Enhances Bone Marrow Stem Cell Engraftment in Infarcted Hearts Through SCF-C-kit and SDF-1-CXCR4 Signaling Axes.
Shahzad U, Li G, Zhang Y, Li RK, Rao V, Yau TM. | 01/16/2016 |
| A 100 nM dose of E2 unbalanced the SCF/c-kit system, with a crucial impact on germ cell survival and thus male fertility. | Estrogenic regulation of testicular expression of stem cell factor and c-kit: implications in germ cell survival and male fertility.
Correia S, Alves MR, Cavaco JE, Oliveira PF, Socorro S. | 08/30/2014 |
| SCF/c-kit signaling pathway is required for maintenance of interstitial cells of Cajal phenotype, survival, proliferation, and differentiation. | Electroacupuncture at ST36 increases contraction of the gastric antrum and improves the SCF/c-kit pathway in diabetic rats.
Chen Y, Xu J, Liu S, Hou X. | 07/5/2014 |
| In diabetic colonic dysmotility, deficiency of endogenous IGF-1 in colonic smooth muscle cells leads to reduction of SCF expression. | Effect of endogenous insulin-like growth factor and stem cell factor on diabetic colonic dysmotility.
Wang Y, Xu XY, Tang YR, Yang WW, Yuan YF, Ning YJ, Yu YJ, Lin L., Free PMC Article | 01/4/2014 |
| The results of this study concluded that Electroacupuncture treatment up-regulates the positive cells and mRNA expression of SCF after cerebral ischemia/reperfusion. | Electroacupuncture improves behavioral recovery and increases SCF/c-kit expression in a rat model of focal cerebral ischemia/reperfusion.
Lu T, Luo Y, Sun H, Qin W, Li Y. | 09/28/2013 |
| These results suggest that overload training inhibits the phagocytosis and the ROS generation of peritoneal macrophages, and that MGF produced by macrophages may play a key role in this process. | Overload training inhibits phagocytosis and ROS generation of peritoneal macrophages: role of IGF-1 and MGF.
Xiao W, Chen P, Wang R, Dong J. | 07/13/2013 |
| activated mature cardiac mast cells are responsible, in a paracrine fashion, for the increase in mature mast cell density post aortocaval fistula by rapidly increasing SCF levels via the release of chymase. | Stem cell factor is responsible for the rapid response in mature mast cell density in the acutely stressed heart.
Li J, Lu H, Plante E, Meléndez GC, Levick SP, Janicki JS., Free PMC Article | 03/2/2013 |
| Stem cell factor gene transfer induces c-kit(+) stem/progenitor cell expansion in situ and cardiomyocyte proliferation, which may represent a new therapeutic strategy to reverse adverse remodeling after myocardial infarction. | Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells.
Yaniz-Galende E, Chen J, Chemaly E, Liang L, Hulot JS, McCollum L, Arias T, Fuster V, Zsebo KM, Hajjar RJ., Free PMC Article | 02/9/2013 |
| results indicate that KL-c-kit interaction plays a role in estrogenic regulation through oocyte-granulosa cell communication | Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulosa cells.
Miyoshi T, Otsuka F, Nakamura E, Inagaki K, Ogura-Ochi K, Tsukamoto N, Takeda M, Makino H. | 09/29/2012 |
| These findings extend current knowledge regarding the role of SCF and G-CSF in the regulation of neurogenesis and provide insights into the contribution of hematopoietic growth factors to brain development and remodeling | Stem cell factor and granulocyte colony-stimulating factor promote neuronal lineage commitment of neural stem cells.
Piao CS, Li B, Zhang LJ, Zhao LR. | 03/24/2012 |
| Expression of SCF+GM-CSF after hepatectomy can contribute to biliary remodeling (e.g., post-transplantation) by functional deregulation of the activity of key signaling intermediates involved in cell expansion and multipotent differentiation. | Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration.
Meng F, Francis H, Glaser S, Han Y, DeMorrow S, Stokes A, Staloch D, Venter J, White M, Ueno Y, Reid LM, Alpini G., Free PMC Article | 02/18/2012 |
| SCF expression in gastric smooth muscle cells is stimulated by IGF-1 in both dose- and time-dependent manners through IGF-1R in which ERKMAPK signal transduction may play an important role. | [Insulin-like growth factor 1 regulates expression of stem cell factor through ERKMAPK signaling pathway in gastric smooth muscle cell].
Ning YJ, Zhang W, Cheng JF, Li XL, Wang MF, Lin L. | 07/30/2011 |
| mRNA upregulated up to 20-fold in intrahepatic cholangiocarcinoma | Expression of stem cell factor and its receptor c-Kit during the development of intrahepatic cholangiocarcinoma.
Mansuroglu T, Ramadori P, Dudás J, Malik I, Hammerich K, Füzesi L, Ramadori G. | 01/21/2010 |
| Upregulation of stem cell factor and c-kit expression occured after spinal cord injury. Stem cell factor could be useful as an agent for treatment of spinal cord injury. | Stem cell factor prevents neuronal cell apoptosis after acute spinal cord injury.
Yamasaki K, Setoguchi T, Takenouchi T, Yone K, Komiya S. | 01/21/2010 |
| Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK. | Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK.
Kuang D, Zhao X, Xiao G, Ni J, Feng Y, Wu R, Wang G. | 01/21/2010 |
| postsynaptic RapGAP SPAR is regulated by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons | Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons.
Ang XL, Seeburg DP, Sheng M, Harper JW., Free PMC Article | 01/21/2010 |
| SCF and its receptor may play a role in the remodelling process of serum nephrotoxic nephritis. | Stem cell factor in a rat model of serum nephrotoxic nephritis.
El Kossi MM, Haylor JL, Johnson TS, El Nahas AM. | 01/21/2010 |
| SCF released from astrocytes directs neural progenitor cell migration under hypoxic conditions. | Hypoxia-induced astrocytes promote the migration of neural progenitor cells via vascular endothelial factor, stem cell factor, stromal-derived factor-1alpha and monocyte chemoattractant protein-1 upregulation in vitro.
Xu Q, Wang S, Jiang X, Zhao Y, Gao M, Zhang Y, Wang X, Tano K, Kanehara M, Zhang W, Ishida T. | 01/21/2010 |
| 4-vinylcyclohexene diepoxide compromises KIT/KITL signaling, which is critical for follicular survival in primordial and primary follicles. | Involvement of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in rats.
Fernandez SM, Keating AF, Christian PJ, Sen N, Hoying JB, Brooks HL, Hoyer PB., Free PMC Article | 01/21/2010 |
| Follicle stimulating hormone has a protective effect on germ cells after unilateral testicular torsion, which is reflected by increased SCF expression. | Change and significance of the expression of c-kit and SCF following recovery from unilateral testicular torsion in rats.
Guan Y, Zheng X, Yang Z, Li S. | 01/21/2010 |