| The role of breast milk beta-endorphin and relaxin-2 on infant colic. | The role of breast milk beta-endorphin and relaxin-2 on infant colic.
Doneray H, Tavlas G, Ozden A, Ozturk N. | 12/22/2023 |
| The dual and multifaceted role of relaxin-2 in cancer. | The dual and multifaceted role of relaxin-2 in cancer.
Kwantwi LB. | 08/30/2023 |
| Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function. | Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function.
Prudencio CB, Nunes SK, Pinheiro FA, Filho CIS, Antônio FI, de Aquino Nava GT, Rudge MVC, Barbosa AMP, Diamater Study Group. | 10/22/2022 |
| Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2. | Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.
Sethi A, Bruell S, Ryan T, Yan F, Tanipour MH, Mok YF, Draper-Joyce C, Khandokar Y, Metcalfe RD, Griffin MDW, Scott DJ, Hossain MA, Petrie EJ, Bathgate RAD, Gooley PR. | 11/27/2021 |
| Recombinant human H2 relaxin (serelaxin) as a cardiovascular drug: aiming at the right target. | Recombinant human H2 relaxin (serelaxin) as a cardiovascular drug: aiming at the right target.
Bani D. | 09/4/2021 |
| Tissue-specific relaxin-2 is differentially associated with the presence/size of an arterial aneurysm and the severity of atherosclerotic disease in humans. | Tissue-specific relaxin-2 is differentially associated with the presence/size of an arterial aneurysm and the severity of atherosclerotic disease in humans.
Papoutsis K, Kapelouzou A, Georgiopoulos G, Kontogiannis C, Kourek C, Mylonas KS, Patelis N, Cokkinos DV, Karavokyros I, Georgopoulos S., Free PMC Article | 03/13/2021 |
| Investigated the potential beneficial effects and mechanisms of relaxin-2 on livers of two mouse models: high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) with simple steatosis, and methionine-choline-deficient (MCD) diet-induced non-alcoholic steatohepatitis (NASH). | Human relaxin-2 attenuates hepatic steatosis and fibrosis in mice with non-alcoholic fatty liver disease.
Lee KC, Hsieh YC, Chan CC, Sun HJ, Huang YH, Hou MC, Lin HC. | 06/27/2020 |
| The relaxin-2 mRNA and protein expression levels are decreased in the chronic rhinosinusitis with nasal polyps (CRSwNP) group compared with the chronic rhinosinusitis without nasal polyps (CRSsNP) group. The levels of TGF-beta1, collagen I, pSmad2/Smad3, Smad2, and Smad3 are decreased after relaxin-2 treatment ex vivo. However, relaxin-2, collagen I, pSmad2/Smad3, Smad2, and Smad3 levels are increased after TGF-beta1 t... | The Role of Relaxin-2 in Tissue Remodeling of Chronic Rhinosinusitis With Nasal Polyps.
Li Y, Tan G, Liu J, Ke X, Shen Y, Huang J, Hu G, Xiang T, Yang Y. | 02/22/2020 |
| This work represents an advance in biomedical science because it shows that serum relaxin-2 could discriminate prostate cancer patients from healthy or BPH controls, so may represent a novel prognostic and diagnostic markers for prostate cancer | Serum relaxin-2 as a novel biomarker for prostate cancer.
Xu Y, Yu Q, Liu Y. | 08/3/2019 |
| This study demonstrates the involvement of ADAM10 and PI3K/Akt signaling in mediating RLX-induced Notch-1 activation. | Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling.
Boccalini G, Sassoli C, Bani D, Nistri S. | 04/27/2019 |
| Data indicate that the small proportion of acute heart failure (AHF) patients achieving relaxin-2 concentrations similar to those observed in pregnancy may survive longer. | The subset of patients with acute heart failure able to secrete relaxin-2 at pregnancy concentrations could have a longer survival: a pilot study.
Miró Ò, Herrero-Puente P, Prieto B, García-García M, García-Hernández P, Martín-Sánchez FJ, Jacob J, Ríos J, Romero R, Gil V, Gayat É, Llorens P, Mebazaa A. | 11/10/2018 |
| RL2 level was inversely related to the severity of the atherosclerotic disease; studies with a larger cohort incorporating a consistent study population are warranted to verify results and shed light on the mechanistic background of these processes | Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis.
Papoutsis K, Kapelouzou A, Tsilimigras DI, Patelis N, Kouvelos G, Schizas D, Karavokyros I, Georgopoulos S., Free PMC Article | 11/3/2018 |
| High RNL2 expression is associated with Neuroblastoma. | Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.
Saeki N, Saito A, Sugaya Y, Amemiya M, Ono H, Komatsuzaki R, Yanagihara K, Sasaki H., Free PMC Article | 10/27/2018 |
| The aim of this study was to investigate plasma levels of relaxin-2 in patients with gestational diabetes mellitus, in comparison to pregnant controls without diabetes. | Plasma levels of relaxin-2 are higher and correlated to C-peptide levels in early gestational diabetes mellitus.
Alonso Lopez Y, Dereke J, Landin-Olsson M, Strevens H, Nilsson C, Hillman M. | 09/22/2018 |
| Second trimester serum concentrations of proRLX2 are not predictive of the development of preeclampsia in pregnancy. | Relaxin-2 connecting peptide (pro-RLX2) levels in second trimester serum samples to predict preeclampsia.
Rehfeldt M, Eklund E, Struck J, Sparwasser A, O'Brien B, Palomaki GE, Köhrle J, Bergmann A, Lambert-Messerlian G. | 09/22/2018 |
| Results indicate that serum relaxin may be a clinically useful indicator for diagnostic and prognostic evaluation in epithelial ovarian cancer (EOC) patients. | Serum relaxin as a diagnostic and prognostic marker in patients with epithelial ovarian cancer.
Guo X, Liu Y, Huang X, Wang Y, Qu J, Lv Y. | 08/18/2018 |
| Opposite actions of urotensin II and relaxin-2 on cellular expression of fibronectin in renal fibrosis | Opposite actions of urotensin II and relaxin-2 on cellular expression of fibronectin in renal fibrosis: A preliminary experimental study.
Cernaro V, Medici MA, Bianco F, Santoro D, Lacquaniti A, Romeo A, Lucisano S, Buemi A, Buemi M. | 05/5/2018 |
| In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting. | Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.
Pintalhao M, Castro-Chaves P, Vasques-Novoa F, Gonçalves F, Mendonça L, Fontes-Carvalho R, Lourenço P, Almeida P, Leite-Moreira A, Bettencourt P. | 11/11/2017 |
| Relaxin-2 significantly upregulated intracellular processes in human female ACL cells, but no effect was observed in male cells. Relaxin increased MMP (MMP1 and MMP3) and decreased alphaSMA and type I and III collagen expression, which may act to alter the structural integrity of the ACL tissue over time. | The Intracellular Effect of Relaxin on Female Anterior Cruciate Ligament Cells.
Konopka JA, DeBaun MR, Chang W, Dragoo JL. | 10/14/2017 |
| Data suggest that enhanced survival of normal prostate epithelial cells (PNT1A cell line) in presence of either or both angiotensin II (Ang II) and relaxin 2 (RLN2) appears to be associated with increased ratio of BCL2/BAX messenger RNA expression; thus, Ang II and/or RLN2 appear to be involved in regulation of apoptosis in prostate epithelium. | A common effect of angiotensin II and relaxin 2 on the PNT1A normal prostate epithelial cell line.
Domińska K, Ochędalski T, Kowalska K, Matysiak-Burzyńska ZE, Płuciennik E, Piastowska-Ciesielska AW. | 03/11/2017 |
| Relaxin in the hypothalamic paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway. | Relaxin in paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway.
Sun HJ, Chen D, Han Y, Zhou YB, Wang JJ, Chen Q, Li YH, Gao XY, Kang YM, Zhu GQ. | 12/17/2016 |
| serelaxin differentially modulates vascular tone in different vascular beds | Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells.
Sarwar M, Samuel CS, Bathgate RA, Stewart DR, Summers RJ., Free PMC Article | 11/5/2016 |
| a novel fusion transcript comprising the RLN1 and RLN2 genes, was identified. | Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer.
Tevz G, McGrath S, Demeter R, Magrini V, Jeet V, Rockstroh A, McPherson S, Lai J, Bartonicek N, An J, Batra J, Dinger ME, Lehman ML, Williams ED, Nelson CC. | 10/1/2016 |
| The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 has been deciphered. | The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1.
Sethi A, Bruell S, Patil N, Hossain MA, Scott DJ, Petrie EJ, Bathgate RAD, Gooley PR., Free PMC Article | 09/10/2016 |
| Although serum relaxin level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS. | Serum relaxin levels in benign hypermobility syndrome.
Em S, Oktayoglu P, Bozkurt M, Caglayan M, Karakoc M, Ucar D, Verim S, Yildiz I, Sariyildiz MA, Evliyaoglu O, Nas K. | 07/30/2016 |