| RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation. | RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation.
Basak M, Das K, Mahata T, Kumar D, Nagar N, Poluri KM, Kumar P, Das P, Stewart A, Maity B., Free PMC Article | 08/19/2023 |
| RGS7 silence protects palmitic acid-induced pancreatic beta-cell injury by inactivating the chemokine signaling pathway. | RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway.
Zhu Y, Li J, Ba T, Sun Y, Chang X. | 04/4/2023 |
| A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity. | A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity.
Basak M, Sengar AS, Das K, Mahata T, Kumar M, Kumar D, Biswas S, Sarkar S, Kumar P, Das P, Stewart A, Maity B., Free PMC Article | 12/31/2022 |
| Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gbeta5 signaling complex. | Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex.
Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA., Free PMC Article | 01/15/2022 |
| Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gbeta5. | Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5.
Jeong E, Kim Y, Jeong J, Cho Y., Free PMC Article | 12/25/2021 |
| Data mapped differences in deuterium exchange between the regulator of G protein signaling 7 (RGS7)-Gbeta5 protein(Gbeta5)-RGS7 family binding protein (R7BP) trimer and the RGS7-Gbeta5 dimer. | Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.
Patil DN, Rangarajan ES, Novick SJ, Pascal BD, Kojetin DJ, Griffin PR, Izard T, Martemyanov KA., Free PMC Article | 04/27/2019 |
| Results found that RGS7 was mutated in 11% of melanomas with three recurrent mutations (p.R44C, p.E383K and p.R416Q). p.R44C was shown to destabilize the protein due to the loss of an H-bond and salt bridge. RGS7 p.R44C has weaker catalytic activity for its substrate Galphao, thus providing a dual mechanism for its loss of function resulting in increase anchorage-independent growth, migration and invasion of melanoma c... | RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.
Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Greenberg P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y., Free PMC Article | 12/1/2018 |
| Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13) | Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα(13).
Scherer SL, Cain MD, Kanai SM, Kaltenbronn KM, Blumer KJ., Free PMC Article | 07/8/2017 |
| R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7. | Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein.
Tayou J, Wang Q, Jang GF, Pronin AN, Orlandi C, Martemyanov KA, Crabb JW, Slepak VZ., Free PMC Article | 11/5/2016 |
| Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval | Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval.
Aissani B, Zhang K, Mensenkamp AR, Menko FH, Wiener HW., Free PMC Article | 04/16/2016 |
| New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy. | New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy.
Postula M, Janicki PK, Rosiak M, Kaplon-Cieslicka A, Trzepla E, Filipiak KJ, Kosior DA, Czlonkowski A, Opolski G. | 01/18/2014 |
| the GAP activity of RGS9-2 showed a strong receptor preference for D2R over MOR. Finally, RGS7 displayed an four times greater GAP activity relative to RGS9-2. | Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.
Masuho I, Xie K, Martemyanov KA., Free PMC Article | 12/14/2013 |
| Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. | Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
Jia L, Linder ME, Blumer KJ., Free PMC Article | 07/2/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| common variation within the RGS7 locus may be involved in multiple sclerosis susceptibility. | Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
McCauley JL, Zuvich RL, Bradford Y, Kenealy SJ, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Mortlock DP, Pericak-Vance MA, Haines JL, McCauley JL, Zuvich RL, Bradford Y, Kenealy SJ, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Mortlock DP, Pericak-Vance MA, Haines JL., Free PMC Articles: PMC2765552, PMC2765552 | 01/21/2010 |
| The DEP domain of RGS7 can directly bind to the third intracellular loop of the M3R and attenuate receptor-induced Ca2+ mobilization in a M3 subtype-selective manner. | The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.
Sandiford SL, Slepak VZ., Free PMC Article | 01/21/2010 |
| cytosolic chaperonin complex-dependent mechanism exists for Gbeta5-RGS7 assembly that utilizes the co-chaperone activity of PhLP1 in a unique way | Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.
Howlett AC, Gray AJ, Hunter JM, Willardson BM., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGenetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
Wang J, Lippman SM, Lee JJ, Yang H, Khuri FR, Kim E, Lin J, Chang DW, Lotan R, Hong WK, Wu X. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
McCauley JL, Zuvich RL, Bradford Y, Kenealy SJ, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Mortlock DP, Pericak-Vance MA, Haines JL, McCauley JL, Zuvich RL, Bradford Y, Kenealy SJ, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Mortlock DP, Pericak-Vance MA, Haines JL. Association analysis of Rgs7 variants with panic disorder.
Hohoff C, Neumann A, Domschke K, Jacob C, Maier W, Fritze J, Bandelow B, Krakowitzky P, Rothermundt M, Arolt V, Deckert J. | 09/10/2008 |
| Galpha-regulated plasma membrane localization and palmitoylation of RGS7. | Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o.
Takida S, Fischer CC, Wedegaertner PB. | 01/21/2010 |
| cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP. | R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism.
Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ. | 01/21/2010 |
| could play a role in synaptic vesicle exocytosis through its interaction with snapin | Snapin interacts with the N-terminus of regulator of G protein signaling 7.
Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH. | 01/21/2010 |
| tumor necrosis factor-alpha regulates the interaction of RGS7 with 14-3-3 | Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha.
Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G, Kim E. | 01/21/2010 |