| RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling. | RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling.
Militi S, Nibhani R, Jalali M, Pauklin S. | 10/13/2023 |
| Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells. | Simultaneous depletion of RB, RBL1 and RBL2 affects endoderm differentiation of human embryonic stem cells.
Nakanoh S, Kadiwala J, Pinte L, Morell CM, Lenaerts AS, Vallier L., Free PMC Article | 12/3/2022 |
| Mutations in the acetylation hotspots of Rbl2 are associated with increased risk of breast cancer. | Mutations in the acetylation hotspots of Rbl2 are associated with increased risk of breast cancer.
Ullah F, Khurshid N, Fatimi Q, Loidl P, Saeed M., Free PMC Article | 04/30/2022 |
| RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function. | RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function.
Samra N, Toubiana S, Yttervik H, Tzur-Gilat A, Morani I, Itzkovich C, Giladi L, Abu Jabal K, Cao JZ, Godley LA, Mory A, Baris Feldman H, Tveten K, Selig S, Weiss K. | 02/12/2022 |
| Biallelic loss-of-function variants in RBL2 in siblings with a neurodevelopmental disorder. | Biallelic loss-of-function variants in RBL2 in siblings with a neurodevelopmental disorder.
Brunet T, Radivojkov-Blagojevic M, Lichtner P, Kraus V, Meitinger T, Wagner M., Free PMC Article | 06/26/2021 |
| A point mutation in LxCxE motif of KDM5A/RBP2 renders it incapable of 130 kDa retinoblastoma-associated protein (p130)-interaction and hence, repression of E2F transcription factor 4 and (E2F)-regulated gene promoters. | Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters.
Zargar ZU, Kimidi MR, Tyagi S., Free PMC Article | 07/20/2019 |
| HSP27 promotes cell cycle progression of MRC-5 cells by suppressing expression of the transcriptional repressors E2F-4 and p130 | Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130.
Park AM, Tsunoda I, Yoshie O., Free PMC Article | 03/9/2019 |
| RBL2/p130 and AKT1 physically interact and AKT phosphorylates RBL2/p130 Ser941, located in the pocket domain, but not when this residue is mutated into Alanine. | RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines.
Pentimalli F, Forte IM, Esposito L, Indovina P, Iannuzzi CA, Alfano L, Costa C, Barone D, Rocco G, Giordano A. | 03/9/2019 |
| Three fold reduced Rbl2/p130 expression in these tumor tissues were noticed compared to their control tissues. DNA obtained from MNAse digested chromatin was used as PCR template. | Nucleosomes positioning around transcriptional start site of tumor suppressor (Rbl2/p130) gene in breast cancer.
Farman FU, Iqbal M, Azam M, Saeed M. | 07/21/2018 |
| UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins | Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.
Iwahori S, Umaña AC, VanDeusen HR, Kalejta RF., Free PMC Article | 06/24/2017 |
| Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation | Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation.
Mileo AM, Mattarocci S, Matarrese P, Anticoli S, Abbruzzese C, Catone S, Sacco R, Paggi MG, Ruggieri A., Free PMC Article | 07/2/2016 |
| Statistical analysis revealed that Rbl2/p130 expression negatively correlates to its promoter methylation (r = -0.412) in tumor tissues. | Promoter Methylation Status Modulate the Expression of Tumor Suppressor (RbL2/p130) Gene in Breast Cancer.
Ullah F, Khan T, Ali N, Malik FA, Kayani MA, Shah ST, Saeed M., Free PMC Article | 05/7/2016 |
| TGF-beta induced RBL2 expression through down-regulating miR-93 in renal cancer cells | TGF-beta induced RBL2 expression in renal cancer cells by down-regulating miR-93.
Shi J, Zhuang Y, Liu XK, Zhang YX, Zhang Y. | 06/20/2015 |
| the inactivation of RB1 or RB2/P130 in uncommitted bone marrow stromal cells facilitates the first steps of adipogenesis. | Silencing of RB1 and RB2/P130 during adipogenesis of bone marrow stromal cells results in dysregulated differentiation.
Capasso S, Alessio N, Di Bernardo G, Cipollaro M, Melone MA, Peluso G, Giordano A, Galderisi U., Free PMC Article | 01/17/2015 |
| expression profiling of miRNAs in high-grade serous ovarian carcinoma indicated miR-106a and its family members were upregulated; findings suggest miR-106a can repress expression of the retinoblastoma family member RBL2 and miR-106a overexpression results in rapid tumor growth and poor differentiation | miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma.
Liu Z, Gersbach E, Zhang X, Xu X, Dong R, Lee P, Liu J, Kong B, Shao C, Wei JJ., Free PMC Article | 06/14/2014 |
| PRMT5 knockdown in non-Hodgkin lymphoma cell lines and primary lymphoma cells leads to RBL2 derepression and RB1 reactivation, which in turn inhibit PRC2 expression. | Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.
Chung J, Karkhanis V, Tae S, Yan F, Smith P, Ayers LW, Agostinelli C, Pileri S, Denis GV, Baiocchi RA, Sif S., Free PMC Article | 02/15/2014 |
| Low expression of RBL2 is associated with glioma. | Down-regulation of miR-106b suppresses the growth of human glioma cells.
Zhang A, Hao J, Wang K, Huang Q, Yu K, Kang C, Wang G, Jia Z, Han L, Pu P. | 09/14/2013 |
| Silencing of RB1 but not RB2/P130 decreases proliferative activity and impairs the differentiation potential of human mesenchymal stem cells. | Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells.
Alessio N, Bohn W, Rauchberger V, Rizzolio F, Cipollaro M, Rosemann M, Irmler M, Beckers J, Giordano A, Galderisi U., Free PMC Article | 06/15/2013 |
| Our hypothesis not only enrich the knowledge of the regulation of ALT, but also indicate that p130 may serve as a potential suppressor of ALT, and gene therapy of p130 may be used in cervical cancers. | A postulated role of p130 in telomere maintenance by human papillomavirus oncoprotein E7.
Zhang W, Tian Y, Chen JJ, Zhao W, Yu X. | 12/8/2012 |
| The results show that continued human papillomavirus 16 E6/E7 expression is necessary in cervical cancer cells to prevent cell-cycle arrest by a repressive p130-DREAM complex. | Disruption of repressive p130-DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cells.
Nor Rashid N, Yusof R, Watson RJ. | 12/3/2011 |
| Hypoproliferation and loss of differentiation in organotypic raft cultures of primary neonatal human foreskin keratinocytes depleted of the alpha and beta isoforms of p63 result from p53-p21-mediated accumulation of retinoblastoma (Rb) family member p130. | p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels.
McDade SS, Patel D, McCance DJ., Free PMC Article | 11/5/2011 |
| The activity of CTCF in controlling Rb2/p130 gene expression is impaired by BORIS, which by binding to the Rb2/p130 gene could trigger changes in the chromatin asset established by CTCF affecting CTCF regulatory activity on Rb2/p130 transcription. | CTCF and BORIS regulate Rb2/p130 gene transcription: a novel mechanism and a new paradigm for understanding the biology of lung cancer.
Fiorentino FP, Macaluso M, Miranda F, Montanari M, Russo A, Bagella L, Giordano A. | 08/6/2011 |
| Human papillomavirus E7 protein K39,42R mutation moderately increased the association with and the destabilization of p130. | Nonconserved lysine residues attenuate the biological function of the low-risk human papillomavirus E7 protein.
Genovese NJ, Broker TR, Chow LT., Free PMC Article | 07/16/2011 |
| Gsk3beta, p130 and beta-catenin form in MSC a complex the functional role of which may be associated with activation of differentiation not coupled to cell cycle arrest. | [The cell cycle regulator p130 and beta-catenin form a complex in mesenchymal stem cells].
Petrov NS, Zhidkova OV, Zenin VV, Rozanov IuM, Popov BV. | 05/28/2011 |
| heterogeneous RB (pRb2 or p16) and p53 (p53, p14, or p21) pathway alterations occur frequently in Burkitt lymphoma | The RB (pRb2/p16) and p53 (p14/p53/p21) tumor-suppressor pathways in endemic Burkitt lymphoma.
Kalungi S, Wabinga H, Bostad L. | 04/9/2011 |