| Effects of NCSTN Mutation on Hair Follicle Components in Mice. | Effects of NCSTN Mutation on Hair Follicle Components in Mice.
Shi TW, Cao W, Zhao QZ, Yu HX, Zhang SS, Hao YB. | 01/28/2023 |
| A pig model carrying heterozygous point mutation of NCSTN simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the Notch-pAMPK-HMGCR pathway. | A pig model carrying heterozygous point mutation of NCSTN simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the Notch-pAMPK-HMGCR pathway.
Song R, Liu K, Wang Y, Qin G, Xiao M, Liu Y, Yang J, Zong R, Yan X, Zheng Q, Zhang H, Hou N, Yao J, Wang X, Wang Y, Zhao J, Zhang X. | 01/28/2023 |
| Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression. | Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression.
Yang J, Wang L, Huang Y, Liu K, Lu C, Si N, Wang R, Liu Y, Zhang X. | 03/13/2021 |
| The missense mutation severely limits the glycosylation of NCSTN to its mature form and impairs the integrity of the gamma-secretase complex as well as its catalytic activity toward its substrate Notch, a critical regulator of B cell and T cell development. Essential requirement for nicastrin in marginal zone and B-1 B cell development. | Essential requirement for nicastrin in marginal zone and B-1 B cell development.
Choi JH, Han J, Theodoropoulos PC, Zhong X, Wang J, Medler D, Ludwig S, Zhan X, Li X, Tang M, Gallagher T, Yu G, Beutler B., Free PMC Article | 07/4/2020 |
| mice defective of the nicastrin subunit of gamma-secretase in oligodendrocytes have hypomyelination in the central nervous system. | Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.
Dries DR, Zhu Y, Brooks MM, Forero DA, Adachi M, Cenik B, West JM, Han YH, Yu C, Arbella J, Nordin A, Adolfsson R, Del-Favero J, Lu QR, Callaerts P, Birnbaum SG, Yu G., Free PMC Article | 12/17/2016 |
| The results of this study showed that elevated p-tau levels in NCT cKO mice and have demonstrated that changes on p-tau were likely caused by enhanced activity of CDK5 but not GSK3beta. | Astroglial Activation and Tau Hyperphosphorylation Precede to Neuron Loss in a Neurodegenerative Mouse Model.
Hou JX, Cheng SS, Chen L, Wang QH, Shi Y, Xu Y, Yin ZY, Chen GQ., Free PMC Article | 11/19/2016 |
| PS1(exon8) interacts with nicastrin, participating in the gamma-secretase complex formation. | Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin.
Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME., Free PMC Article | 10/1/2016 |
| nicastrin plays essential roles in the regulation of short- and long-term synaptic plasticity, highlighting the importance of gamma-secretase in the function of mature synapses | Synaptic function of nicastrin in hippocampal neurons.
Lee SH, Sharma M, Südhof TC, Shen J., Free PMC Article | 09/13/2014 |
| These results reveal a key role for ncstn in modulating amyloid beta production and amyloid plaque formation. | Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.
Sesele K, Thanopoulou K, Paouri E, Tsefou E, Klinakis A, Georgopoulos S. | 06/28/2014 |
| Upregulation of PS1/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease. | Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.
Li T, Li YM, Ahn K, Price DL, Sisodia SS, Wong PC., Free PMC Article | 02/7/2014 |
| Pen-2, as well as nicastrin and Aph-1alpha, is dispensable for presenilin endoproteolysis | Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment.
Mao G, Cui MZ, Li T, Jin Y, Xu X., Free PMC Article | 01/12/2013 |
| SGK1 is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT. | Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.
Mo JS, Yoon JH, Hong JA, Kim MY, Ann EJ, Ahn JS, Kim SM, Baek HJ, Lang F, Choi EJ, Park HS., Free PMC Article | 09/22/2012 |
| Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. | Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.
Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T., Free PMC Article | 03/3/2012 |
| we found gamma-secretase components, including nicastrin, to cleave BCG-derived Ag85B to produce a peptide epitope | Cutting edge: Nicastrin and related components of γ-secretase generate a peptide epitope facilitating immune recognition of intracellular mycobacteria, through MHC class II-dependent priming of T cells.
Singh CR, Bakhru P, Khan A, Li QB, Jagannath C., Free PMC Article | 01/14/2012 |
| single residues in a gamma-secretase component besides presenilin are able to differentially affect amyloid precursor protein and Notch processing. | Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.
Pamrén A, Wanngren J, Tjernberg LO, Winblad B, Bhat R, Näslund J, Karlström H., Free PMC Article | 12/10/2011 |
| increased NADH levels resulting from ENOX2 inhibition result in decreased prosurvival sphingosine-1-phosphate and increased proapoptotic ceramide, both of which may be important to initiation of the ENOX2 inhibitor-induced apoptotic cascade. | ER-stress-inducible Herp, facilitates the degradation of immature nicastrin.
Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H. | 09/10/2011 |
| Nicastrin acts to stabilize gamma-secretase but is not required for substrate recognition | Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.
Zhao G, Liu Z, Ilagan MX, Kopan R., Free PMC Article | 03/8/2010 |
| Synoviolin-mediated ubiquitination is involved in the degradation of immature nicastrin, and probably regulates amyloid beta-protein generation. | An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein.
Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H. | 01/21/2010 |
| S-palmitoylation plays a role in stability and raft localization of nicastrin and APH-1, but does not directly modulate gamma-secretase processing of APP and other substrates. | S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G., Free PMC Article | 01/21/2010 |
| main role of the Glu(332) is in the maturation and assembly of gamma-secretase rather than in the recognition of the substrates | Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.
Chávez-Gutiérrez L, Tolia A, Maes E, Li T, Wong PC, de Strooper B. | 01/21/2010 |
| Levels of beta-site APP-cleaving enzyme (BACE-1) and of nicastrin, a component of gamma-secretase, both increase in HSV1-infected cells. | Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation.
Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB. | 01/21/2010 |
| The results establish a novel mechanism linking the EGFR pathway to the tumor suppressor role of gamma-secretase. | Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.
Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC. | 01/21/2010 |
| Nicastrin is essential for the gamma-secretase cleavage of APP and Notch in mammalian cells and that Nicastrin has both positive and negative functions in the regulation of gamma-secretase activity | Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.
Li J, Fici GJ, Mao CA, Myers RL, Shuang R, Donoho GP, Pauley AM, Himes CS, Qin W, Kola I, Merchant KM, Nye JS. | 01/21/2010 |
| a genetic modifier on mouse distal chromosome 1, coinciding with the locus containing Nicastrin, influences presenilin-mediated Notch S3-site cleavage and the resultant Notch phenotype without affecting presenilin-mediated APP gamma-site cleavage | Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, Fraser P, Westaway D, St George-Hyslop P., Free PMC Article | 01/21/2010 |
| Mature glycosylation and trafficking modulate its binding to presenilins | Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, Fraser PE. | 01/21/2010 |