| Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation. | Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation.
Wu C, Cai X, Wang Y, Rodriguez CD, Zoaldi G, Herrmann L, Huang CY, Wang X, Sanghvi VR, Lu RO, Meng Z., Free PMC Article | 06/3/2024 |
| TGF-beta1-induced RAP2 regulates invasion in pancreatic cancer. | TGF-β1-induced RAP2 regulates invasion in pancreatic cancer.
Jin K, Liu C, Cheng H, Fei Q, Huang Q, Xiao Z, Yu X, Wu W., Free PMC Article | 05/14/2022 |
| Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration. | Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration.
Duncan ED, Han KJ, Trout MA, Prekeris R., Free PMC Article | 05/7/2022 |
| Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation. | Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.
Shi S, Li J, Li E, Guo W, He Y, Wang J, Zhang Y, Yue L, Wei L., Free PMC Article | 02/26/2022 |
| RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway. | RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway.
Yang JR, Ling XL, Guan QL. | 01/22/2022 |
| Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A. | Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A.
Lian Y, Jiang D, Sun J., Free PMC Article | 12/25/2021 |
| lncRNA FLVCR1AS1 drives colorectal cancer progression via modulation of the miR381/RAP2A axis. | lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis.
Han Y, Wang X, Mao E, Shen B, Huang L., Free PMC Article | 05/15/2021 |
| Abnormal expression of Rap2A as a prognostic marker for human breast cancer. | Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Liu JQ, Zhao LP, Liu SX, Sun W, Qi HY. | 05/8/2021 |
| Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum. | Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum.
Zhang MY, Zhang Y, Wu XD, Zhang K, Lin P, Bian HJ, Qin MM, Huang W, Wei D, Zhang Z, Wu J, Chen R, Feng F, Wang B, Nan G, Zhu P, Chen ZN., Free PMC Article | 03/23/2019 |
| The phosphorylation also produces an increase in GAP activity toward Rap2 , an effect not produced by either kinase alone. | Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases.
Walkup WG 4th, Sweredoski MJ, Graham RL, Hess S, Kennedy MB., Free PMC Article | 03/16/2019 |
| RAP2 mediates mechanoresponses of the Hippo pathway; RAP2 is a molecular switch in mechanotransduction, thereby defining a mechanosignalling pathway from extracellular matrix stiffness to the nucleus | RAP2 mediates mechanoresponses of the Hippo pathway.
Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL., Free PMC Article | 03/9/2019 |
| These findings indicate that Rap2a promotes renal cell carcinoma metastasis and may serve as a candidate renal cell carcinoma prognostic marker and a potential therapeutic target. | Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Wu JX, Du WQ, Wang XC, Wei LL, Huo FC, Pan YJ, Wu XJ, Pei DS., Free PMC Article | 02/9/2019 |
| The small GTPase Ras-related protein 2 (Rap2) was found to bind ArrB1 under resting conditions but dissociated upon formyl-Met-Leu-Phe stimulation. | β-Arrestin 1-dependent regulation of Rap2 is required for fMLP-stimulated chemotaxis in neutrophil-like HL-60 cells.
Gera N, Swanson KD, Jin T., Free PMC Article | 09/2/2017 |
| Nedd4-1 inhibited Rap2a activity, and promoted the migration and invasion of glioma cells. | Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1.
Wang L, Zhu B, Wang S, Wu Y, Zhan W, Xie S, Shi H, Yu R., Free PMC Article | 06/24/2017 |
| present review mainly focused on recent studies on the functional and physical interactions between Rap2 and its effectors. We also speculated on the relevance of these pathways to tumorigenesis | Role of Rap2 and its Downstream Effectors in Tumorigenesis.
Huang H, Di J, Qu D, Gao Z, Zhang Y, Zheng J. | 08/13/2016 |
| Single nucleotide polymorphism in RAP2A gene is associated with Peripheral Arterial Disease. | Genome-Wide Association Study of Peripheral Arterial Disease in a Japanese Population.
Matsukura M, Ozaki K, Takahashi A, Onouchi Y, Morizono T, Komai H, Shigematsu H, Kudo T, Inoue Y, Kimura H, Hosaka A, Shigematsu K, Miyata T, Watanabe T, Tsunoda T, Kubo M, Tanaka T., Free PMC Article | 06/11/2016 |
| the role of Rap2a in carcinogenesis | [Identification analysis of eukaryotic expression plasmid Rap2a and its effect on the migration of lung cancer cells].
Wu J, Sang M, Cao W, Zheng J, Pei D., Free PMC Article | 02/27/2016 |
| The ectopic expression of Rap2a enhances the migration and invasive ability of cancer cells and increases activities of matrix metalloproteinase MMP2 and MMP9. | Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.
Wu JX, Zhang DG, Zheng JN, Pei DS. | 12/26/2015 |
| Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. | Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.
Walkup WG 4th, Washburn L, Sweredoski MJ, Carlisle HJ, Graham RL, Hess S, Kennedy MB., Free PMC Article | 05/9/2015 |
| downregulation of Rap2a promoted glioma migration and invasion, and raised the phosphorylation level of AKT | Over-expression of Rap2a inhibits glioma migration and invasion by down-regulating p-AKT.
Wang L, Zhan W, Xie S, Hu J, Shi Q, Zhou X, Wu Y, Wang S, Fei Z, Yu R. | 10/18/2014 |
| endothelial barrier resistance is determined by the combined antagonistic actions of Rap1 and Rap2 | Rap1 and Rap2 antagonistically control endothelial barrier resistance.
Pannekoek WJ, Linnemann JR, Brouwer PM, Bos JL, Rehmann H., Free PMC Article | 08/31/2013 |
| Rap2A and TNIK control brush border formation by apical recruitment of MST4 and the subsequent phosphorylation of Ezrin | Rap2A links intestinal cell polarity to brush border formation.
Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL. | 10/20/2012 |
| analyzed residues that allow RasGEF1 proteins to discriminate between Rap1 and Rap2, and identified Phe39 in the switch I region of Rap2 as a specificity residue. | RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange.
Yaman E, Gasper R, Koerner C, Wittinghofer A, Tazebay UH. | 01/21/2010 |
| The beta2 integrin-dependent exocytosis of specific and gelatinase B-containing granules is responsible for the translocation of Rap1 and Rap2 to the plasma membrane in human neutrophils. | Beta2 integrins target Rap GTPases to the plasma membrane by means of degranulation.
Dib K, Axelsson L, Andersson T. | 01/21/2010 |
| Study presents evidence of fewer spines and reduced signaling in Rap2 transgenic mice, consistent with an inhibitory role for Rap2 at synapses. | Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction.
Ryu J, Futai K, Feliu M, Weinberg R, Sheng M., Free PMC Article | 01/21/2010 |