| Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability. | Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability.
Kosuru R, Romito O, Sharma GP, Ferraresso F, Ghadrdoost Nakhchi B, Yang K, Mammoto T, Mammoto A, Kastrup CJ, Zhang DX, Goldspink PH, Trebak M, Chrzanowska M., Free PMC Article | 10/25/2024 |
| TRF2-RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM-DNA2-dependent 5'-end resection. | TRF2-RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM-DNA2-dependent 5'-end resection.
Liang F, Rai R, Sodeinde T, Chang S., Free PMC Article | 10/9/2024 |
| Activation of the MEK/ERK Pathway Mediates the Inhibitory Effects of Silvestrol on Nasopharyngeal Carcinoma Cells via RAP1A, HK2, and GADD45A. | Activation of the MEK/ERK Pathway Mediates the Inhibitory Effects of Silvestrol on Nasopharyngeal Carcinoma Cells via RAP1A, HK2, and GADD45A.
Yu LR, Han XZ, Tang YZ, Liu D, Luo XQ, Qiu XW, Feng J, Yuan WX, Ding JY. | 05/24/2024 |
| ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak. | ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak.
Khan A, Ni W, Baltazar T, Lopez-Giraldez F, Pober JS, Pierce RW., Free PMC Article | 04/30/2022 |
| Natural Killer Cell Transcript 4 promotes the development of Sjgren's syndrome via activation of Rap1 on B cells. | Natural Killer Cell Transcript 4 promotes the development of Sjӧgren's syndrome via activation of Rap1 on B cells.
Qu P, Wuest T, Min Y, Alevizos I, Young HA, Lin PC., Free PMC Article | 11/27/2021 |
| Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas. | Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas.
Carabias A, Gómez-Hernández M, de Cima S, Rodríguez-Blázquez A, Morán-Vaquero A, González-Sáenz P, Guerrero C, de Pereda JM. | 10/30/2021 |
| Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell-Cell Junctions and Vascular Permeability. | Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell-Cell Junctions and Vascular Permeability.
Yamamoto K, Takagi Y, Ando K, Fukuhara S. | 10/9/2021 |
| Involvement of miR-337 in high glucose-suppressed osteogenic differentiation in bone marrow mesenchymal stem cells via negative regulation of Rap1A. | Involvement of miR-337 in high glucose-suppressed osteogenic differentiation in bone marrow mesenchymal stem cells via negative regulation of Rap1A.
Liu S, Yang X, Zhong X, Li L, Zhang X. | 10/9/2021 |
| Identification of Radil as a Ras binding partner and putative activator. | Identification of Radil as a Ras binding partner and putative activator.
Choi BH, Kou Z, Colon TM, Chen CH, Chen Y, Dai W., Free PMC Article | 08/28/2021 |
| The Mystery of Rap1 Suppression of Oncogenic Ras. | The Mystery of Rap1 Suppression of Oncogenic Ras.
Nussinov R, Jang H, Zhang M, Tsai CJ, Sablina AA., Free PMC Article | 06/12/2021 |
| Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis. | Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis.
Perdomo L, Vidal-Gómez X, Soleti R, Vergori L, Duluc L, Chwastyniak M, Bisserier M, Le Lay S, Villard A, Simard G, Meilhac O, Lezoualc'h F, Khantalin I, Veerapen R, Dubois S, Boursier J, Henni S, Gagnadoux F, Pinet F, Andriantsitohaina R, Martínez MC, Metabol study Group., Free PMC Article | 05/29/2021 |
| Functional and structural characterization of allosteric activation of phospholipase Cepsilon by Rap1A. | Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A.
Sieng M, Selvia AF, Garland-Kuntz EE, Hopkins JB, Fisher IJ, Marti AT, Lyon AM., Free PMC Article | 05/8/2021 |
| Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics. | Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics.
Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Zhang J, Ling M, Trejo J, Levchenko A, Zhang J., Free PMC Article | 02/20/2021 |
| MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A. | MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A.
Lu J, Zhou L, Wu B, Duan Y, Sun Y, Gu L, Xu D, Du C. | 10/31/2020 |
| Long noncoding RNA CRNDE promotes proliferation, migration and invasion in prostate cancer through miR-101/Rap1A. | Long noncoding RNA CRNDE promotes proliferation, migration and invasion in prostate cancer through miR-101/Rap1A.
Chen JH, Tong W, Pu XF, Wang JZ. | 09/12/2020 |
| cooperative binding of Rap1 to the talin F0 and F1 domains synergizes with membrane PIP2 binding to spatiotemporally position and activate talins to regulate integrin activity | Rap1 and membrane lipids cooperatively recruit talin to trigger integrin activation.
Bromberger T, Zhu L, Klapproth S, Qin J, Moser M., Free PMC Article | 08/1/2020 |
| When amino acids are limited, the Rap1-GTPases confine lysosomes to the perinuclear region and reduce lysosome abundance, which suppresses mTORC1 signaling. | Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.
Mutvei AP, Nagiec MJ, Hamann JC, Kim SG, Vincent CT, Blenis J., Free PMC Article | 08/1/2020 |
| The authors demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis. | Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis.
Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J., Free PMC Article | 05/16/2020 |
| Mechanistically, adenosine produced by CD73 binds to adenosine A2A receptor (A2AR) and activates Rap1, which recruits P110beta to the plasma membrane and triggers PIP3 production, thereby promoting AKT phosphorylation in HCC cells. | CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis.
Ma XL, Shen MN, Hu B, Wang BL, Yang WJ, Lv LH, Wang H, Zhou Y, Jin AL, Sun YF, Zhang CY, Qiu SJ, Pan BS, Zhou J, Fan J, Yang XR, Guo W., Free PMC Article | 05/16/2020 |
| study has shown that Rap1 is required for the formation of the replication-permissive vacuole of an intracellular bacterial pathogen. | Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.
Hilbi H, Kortholt A., Free PMC Article | 04/11/2020 |
| Rap1A was found to be upregulated in esophageal squamous cell carcinoma tissues and its expression was correlated with cancer stage. Rap1A could promote ESCC metastasis by stimulating cell migration and invasion. Furthermore, Rap1A promoted epithelialtoepithelialtomesenchymal transition, possibly through the AKT signaling pathway. These findings indicated that Rap1A may be a potential prognostic marker for ESCC. | Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
Li Q, Xu A, Chu Y, Chen T, Li H, Yao L, Zhou P, Xu M., Free PMC Article | 03/28/2020 |
| LINC00460 regulats Rap1A expression through competitively binding to miR-30a-3p. | Long noncoding RNA LINC00460 aggravates invasion and metastasis by targeting miR-30a-3p/Rap1A in nasopharyngeal carcinoma.
Hu X, Liu W, Jiang X, Wang B, Li L, Wang J, Ma J. | 02/29/2020 |
| RAP1 levels are predictive of the success of chemotherapy in breast and colon cancer. | Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
Khattar E, Maung KZY, Chew CL, Ghosh A, Mok MMH, Lee P, Zhang J, Chor WHJ, Cildir G, Wang CQ, Mohd-Ismail NK, Chin DWL, Lee SC, Yang H, Shin YJ, Nam DH, Chen L, Kumar AP, Deng LW, Ikawa M, Gunaratne J, Osato M, Tergaonkar V., Free PMC Article | 02/29/2020 |
| we firstly found that miR-142-5p was downregulated in pancreatic cancer tumor tissues while Ras-related protein Rap-1 A (RAP1A) was upregulated compared with para-carcinoma non-tumor tissues. Then, we found that RAP1A could be a putative target gene of miR-142-5p | miR-142-5p regulates pancreatic cancer cell proliferation and apoptosis by regulation of RAP1A.
Yao R, Xu L, Wei B, Qian Z, Wang J, Hui H, Sun Y. | 01/11/2020 |
| genome-wide association study Identification as a novel susceptibility gene for Crohn's disease in Japanese individuals | A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals.
Kakuta Y, Kawai Y, Naito T, Hirano A, Umeno J, Fuyuno Y, Liu Z, Li D, Nakano T, Izumiyama Y, Ichikawa R, Okamoto D, Nagai H, Matsumoto S, Yamamoto K, Yokoyama N, Chiba H, Shimoyama Y, Onodera M, Moroi R, Kuroha M, Kanazawa Y, Kimura T, Shiga H, Endo K, Negoro K, Yasuda J, Esaki M, Tokunaga K, Nakamura M, Matsumoto T, McGovern DPB, Nagasaki M, Kinouchi Y, Shimosegawa T, Masamune A., Free PMC Article | 01/11/2020 |