| Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease. | Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease.
Clemons GA, Silva ACE, Acosta CH, Udo MSB, Tesic V, Rodgers KM, Wu CY, Citadin CT, Lee RH, Neumann JT, Allani S, Prentice H, Zhang Q, Lin HW., | 06/18/2024 |
| Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1. | Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.
Garbutt TA, Wang Z, Wang H, Ma H, Ruan H, Dong Y, Xie Y, Tan L, Phookan R, Stouffer JA, Vedantham V, Yang Y, Qian L, Liu J., | 05/31/2024 |
| CARM1 arginine methyltransferase as a therapeutic target for cancer. | CARM1 arginine methyltransferase as a therapeutic target for cancer.
Santos M, Hwang JW, Bedford MT., Free PMC Article | 03/21/2024 |
| Sex-Specific Effect of CARM1 in Skeletal Muscle Adaptations to Exercise. | Sex-Specific Effect of CARM1 in Skeletal Muscle Adaptations to Exercise.
Vanlieshout TL, Stouth DW, Raziee R, Sraka AJ, Masood HA, Ng SY, Mattina SR, Mikhail AI, Manta A, Ljubicic V. | 02/16/2024 |
| Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation. | Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation.
Zhang L, Jiao G, You Y, Li X, Liu J, Sun Z, Li Q, Dai Z, Ma J, Zhou H, Li G, Meng C, Chen Y., Free PMC Article | 09/19/2023 |
| PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARgamma. | PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ.
Zhong Y, Wang Y, Li X, Qin H, Yan S, Rao C, Fan D, Liu D, Deng F, Miao Y, Yang L, Huang K., Free PMC Article | 08/1/2023 |
| Role of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in the Regulation of the Biological Function of 1,25-Dihydroxyvitamin D3. | Role of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in the Regulation of the Biological Function of 1,25-Dihydroxyvitamin D(3).
Mady LJ, Zhong Y, Dhawan P, Christakos S., Free PMC Article | 07/12/2023 |
| The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer. | The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer.
Gao G, Hausmann S, Flores NM, Benitez AM, Shen J, Yang X, Person MD, Gayatri S, Cheng D, Lu Y, Liu B, Mazur PK, Bedford MT., Free PMC Article | 01/28/2023 |
| The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology. | The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology.
vanLieshout TL, Stouth DW, Hartel NG, Vasam G, Ng SY, Webb EK, Rebalka IA, Mikhail AI, Graham NA, Menzies KJ, Hawke TJ, Ljubicic V., Free PMC Article | 09/24/2022 |
| The arginine methyltransferase Carm1 is necessary for heart development. | The arginine methyltransferase Carm1 is necessary for heart development.
Jamet S, Ha S, Ho TH, Houghtaling S, Timms A, Yu K, Paquette A, Maga AM, Greene NDE, Beier DR., Free PMC Article | 08/13/2022 |
| A novel CARM1-HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy. | A novel CARM1-HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy.
Ravel-Chapuis A, Haghandish A, Daneshvar N, Jasmin BJ, Côté J. | 05/14/2022 |
| The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis. | The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis.
Zhang LX, Gao J, Long X, Zhang PF, Yang X, Zhu SQ, Pei X, Qiu BQ, Chen SW, Lu F, Lin K, Xu JJ, Wu YB., Free PMC Article | 05/14/2022 |
| PRMT4 drives post-ischemic angiogenesis via YB1/VEGF signaling. | PRMT4 drives post-ischemic angiogenesis via YB1/VEGF signaling.
Yan S, Hu J, Li J, Wang P, Wang Y, Wang Z. | 02/5/2022 |
| Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia. | Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
Lai Y, Li X, Li T, Nyunoya T, Chen K, Kitsios GD, Nouraie SM, Zhang Y, McVerry BJ, Lee JS, Mallampalli RK, Zou C., Free PMC Article | 01/29/2022 |
| Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6. | Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6.
Cheng D, Gao G, Di Lorenzo A, Jayne S, Hottiger MO, Richard S, Bedford MT., Free PMC Article | 03/20/2021 |
| Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy. | Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy.
Yu YS, Shin HR, Kim D, Baek SA, Choi SA, Ahn H, Shamim A, Kim J, Kim IS, Kim KK, Won KJ, Baek SH., Free PMC Article | 01/9/2021 |
| WDR5-Myc axis promotes the progression of glioblastoma and neuroblastoma by transcriptional activating CARM1. | WDR5-Myc axis promotes the progression of glioblastoma and neuroblastoma by transcriptional activating CARM1.
Wang F, Zhang J, Ke X, Peng W, Zhao G, Peng S, Xu J, Xu B, Cui H. | 09/12/2020 |
| In vivo, cardiac-specific overexpression of PRMT4 resulted in decreased survival rate, reduced left ventricular function, and aggravated cardiac remodeling following myocardial infarction. Mechanistically, PRMT4 overexpression promoted hypoxia-induced cardiomyocytes apoptosis, while its inhibition abolished these effects. | PRMT4 overexpression aggravates cardiac remodeling following myocardial infarction by promoting cardiomyocyte apoptosis.
Wang Y, Ju C, Hu J, Huang K, Yang L. | 07/18/2020 |
| CARM1 interacts with and asymmetrically dimethylates FoxO3 | CARM1 contributes to skeletal muscle wasting by mediating FoxO3 activity and promoting myofiber autophagy.
Liu Y, Li J, Shang Y, Guo Y, Li Z. | 05/9/2020 |
| demonstrate that CARM1 contributes to airway repair and regeneration by regulating airway epithelial cell senescence | CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis.
Sarker RSJ, Conlon TM, Morrone C, Srivastava B, Konyalilar N, Verleden SE, Bayram H, Fehrenbach H, Yildirim AÖ. | 04/11/2020 |
| our data demonstrate that CARM1 is required for transcriptional activation of a subset of RA target genes, and we uncover changes in the recruitment of Suz12 and the epigenetic H3K27me3 and H3K27ac marks at gene regulatory regions for CRABP2 and NR2F1 during RA-induced differentiation. | CARM1 (PRMT4) Acts as a Transcriptional Coactivator during Retinoic Acid-Induced Embryonic Stem Cell Differentiation.
Quintero CM, Laursen KB, Mongan NP, Luo M, Gudas LJ., Free PMC Article | 10/5/2019 |
| The Carm1 is a specific substrate of p38gamma/MAPK12 and that phosphorylation of Carm1 prevents its nuclear translocation. | The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment.
Chang NC, Sincennes MC, Chevalier FP, Brun CE, Lacaria M, Segalés J, Muñoz-Cánoves P, Ming H, Rudnicki MA., Free PMC Article | 09/7/2019 |
| CARM1 accumulates in nuclear granules at the 2- to 4-cell stage transition in the mouse embryo, with the majority corresponding to paraspeckles. The paraspeckle component Neat1 and its partner p54nrb are required for CARM1's association with paraspeckles and for H3R26 methylation. | CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development.
Hupalowska A, Jedrusik A, Zhu M, Bedford MT, Glover DM, Zernicka-Goetz M., Free PMC Article | 08/31/2019 |
| High nuclear Carm1 levels negatively impact the p300*ACT*CREMtau axis during late stages of spermiogenesis. | The arginine methyltransferase CARM1 represses p300•ACT•CREMτ activity and is required for spermiogenesis.
Bao J, Rousseaux S, Shen J, Lin K, Lu Y, Bedford MT., Free PMC Article | 07/27/2019 |
| CARM1 methylates PKM2 at arginines 445 and 447, which enhances PKM2 tetramer formation. Consequently, Carm1 knockout cells exhibit significant survival advantages over WT cells when extracellular serine is limited, likely due to their enhanced de novo serine synthesis capacity. Altogether, we identified CARM1 as an important regulator of glucose metabolism and serine synthesis. | CARM1 suppresses de novo serine synthesis by promoting PKM2 activity.
Abeywardana T, Oh M, Jiang L, Yang Y, Kong M, Song J, Yang Y., Free PMC Article | 03/9/2019 |