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    RANBP2 RAN binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 5903, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children.

    Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children.
    Lin Q, Chen W, Tan J, Qian S, Su H, Zhao L, Yuan L, Ruan J, Huang X, Zhou H., Free PMC Article

    07/24/2024
    Intense work-up is required for pediatric COVID-related acute necrotizing encephalopathy with RANBP2 variants.

    Intense work-up is required for pediatric COVID-related acute necrotizing encephalopathy with RANBP2 variants.
    Finsterer J, Scorza FA., Free PMC Article

    04/12/2023
    Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.

    Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.
    Yi J, Zhao X, Noell CR, Helmer P, Solmaz SR, Vallee RB., Free PMC Article

    03/22/2023
    Aurora B SUMOylation Is Restricted to Centromeres in Early Mitosis and Requires RANBP2.

    Aurora B SUMOylation Is Restricted to Centromeres in Early Mitosis and Requires RANBP2.
    Di Cesare E, Moroni S, Bartoli J, Damizia M, Giubettini M, Koerner C, Krenn V, Musacchio A, Lavia P., Free PMC Article

    02/15/2023
    Outcomes in influenza and RANBP2 mutation-associated acute necrotizing encephalopathy of childhood.

    Outcomes in influenza and RANBP2 mutation-associated acute necrotizing encephalopathy of childhood.
    Chatur N, Yea C, Ertl-Wagner B, Yeh EA.

    07/16/2022
    Roles of Nucleoporin RanBP2/Nup358 in Acute Necrotizing Encephalopathy Type 1 (ANE1) and Viral Infection.

    Roles of Nucleoporin RanBP2/Nup358 in Acute Necrotizing Encephalopathy Type 1 (ANE1) and Viral Infection.
    Jiang J, Wang YE, Palazzo AF, Shen Q., Free PMC Article

    04/23/2022
    RANBP2 mutation causing autosomal dominant acute necrotizing encephalopathy attenuates its interaction with COX11.

    RANBP2 mutation causing autosomal dominant acute necrotizing encephalopathy attenuates its interaction with COX11.
    Shibata A, Kasai M, Hoshino A, Tanaka T, Mizuguchi M.

    02/5/2022
    The RanBP2/RanGAP1-SUMO complex gates beta-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.

    The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.
    Blondel-Tepaz E, Leverve M, Sokrat B, Paradis JS, Kosic M, Saha K, Auffray C, Lima-Fernandes E, Zamborlini A, Poupon A, Gaboury L, Findlay J, Baillie GS, Enslen H, Bouvier M, Angers S, Marullo S, Scott MGH.

    10/16/2021
    Acute necrotizing encephalopathy-linked mutations in Nup358 impair interaction of Nup358 with TNRC6/GW182 and miRNA function.

    Acute necrotizing encephalopathy-linked mutations in Nup358 impair interaction of Nup358 with TNRC6/GW182 and miRNA function.
    Deshmukh P, Singh A, Khuperkar D, Joseph J.

    08/28/2021
    Genetic Acute Necrotizing Encephalopathy Associated with RANBP2: Clinical and Therapeutic Implications in Pediatrics.

    Genetic Acute Necrotizing Encephalopathy Associated with RANBP2: Clinical and Therapeutic Implications in Pediatrics.
    Levine JM, Ahsan N, Ho E, Santoro JD., Free PMC Article

    07/24/2021
    The miRISC component AGO2 has multiple binding sites for Nup358 SUMO-interacting motif.

    The miRISC component AGO2 has multiple binding sites for Nup358 SUMO-interacting motif.
    Deshmukh P, Markande S, Fandade V, Ramtirtha Y, Madhusudhan MS, Joseph J.

    07/24/2021
    Endogenously expressed Ranbp2 is not at the axon initial segment.

    Endogenously expressed Ranbp2 is not at the axon initial segment.
    Ogawa Y, Rasband MN., Free PMC Article

    07/24/2021
    RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes.

    RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes.
    Shen Q, Wang YE, Truong M, Mahadevan K, Wu JJ, Zhang H, Li J, Smith HW, Smibert CA, Palazzo AF., Free PMC Article

    06/26/2021
    MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6.

    MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6.
    Xie L, Chen L, Zhong C, Yu T, Ju Z, Wang M, Xiong H, Zeng Y, Wang J, Hu H, Hou W, Feng Y., Free PMC Article

    06/26/2021
    SIRT1 Regulates N(6) -Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2-Dependent FTO SUMOylation.

    SIRT1 Regulates N(6) -Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2-Dependent FTO SUMOylation.
    Liu X, Liu J, Xiao W, Zeng Q, Bo H, Zhu Y, Gong L, He D, Xing X, Li R, Zhou M, Xiong W, Zhou Y, Zhou J, Li X, Guo F, Xu C, Chen X, Wang X, Wang F, Wang Q, Cao K.

    05/8/2021
    [Deleted in lymphocytic leukemia 1 promoted proliferation and apoptosis of nephroblastoma cells through regulating miR-513a-5p and RANBP2 pathway].

    [Deleted in lymphocytic leukemia 1 promoted proliferation and apoptosis of nephroblastoma cells through regulating miR-513a-5p and RANBP2 pathway].
    Zhao JL, Zhao LL, Niu WZ, Ding XC, Zhang WL.

    01/9/2021
    Conformational Dynamics from Ambiguous Zinc Coordination in the RanBP2-Type Zinc Finger of RBM5.

    Conformational Dynamics from Ambiguous Zinc Coordination in the RanBP2-Type Zinc Finger of RBM5.
    Soni K, Martínez-Lumbreras S, Sattler M.

    01/2/2021
    RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair.

    RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair.
    Moreno-Oñate M, Herrero-Ruiz AM, García-Dominguez M, Cortés-Ledesma F, Ruiz JF.

    01/2/2021
    Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import.

    Nup358 and Transportin 1 Cooperate in Adenoviral Genome Import.
    Carlon-Andres I, Lagadec F, Pied N, Rayne F, Lafon ME, Kehlenbach RH, Wodrich H., Free PMC Article

    10/31/2020
    The interactions of GCN5L1, RanBP2 and alphaTAT1 function in concert to control alpha-tubulin acetylation and may contribute towards the regulation of cellular lysosome positioning.

    GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking.
    Wu K, Wang L, Chen Y, Pirooznia M, Singh K, Wälde S, Kehlenbach RH, Scott I, Gucek M, Sack MN., Free PMC Article

    01/11/2020
    Stratified analysis revealed no significant association for any of the four polymorphisms, rs56109543 C>T, rs7132224 A>G, rs14035 C>T in RAN gene, or rs2462788 C>T in RANBP2 and neuroblastoma

    RAN/RANBP2 polymorphisms and neuroblastoma risk in Chinese children: a three-center case-control study.
    Wang J, Zhuo Z, Chen M, Zhu J, Zhao J, Zhang J, Chen S, He J, Zhou H., Free PMC Article

    08/3/2019
    We describe three in vitro reconstituted disassembly intermediates, which show binding of a Crm1 export complex via two FG-repeat patches, cargo-release by RanBP2's Ran-binding domains and retention of free Crm1 at RanBP2 after Ran-GTP hydrolysis.

    The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.
    Ritterhoff T, Das H, Hofhaus G, Schröder RR, Flotho A, Melchior F., Free PMC Article

    09/22/2018
    RAN binding protein 2 increase the sumoylation of cyclin-dependent kinase inhibitor 1B in cholangiocarcinoma cell line QBC939.

    Sumoylation in p27kip1 via RanBP2 promotes cancer cell growth in cholangiocarcinoma cell line QBC939.
    Yang J, Liu Y, Wang B, Lan H, Liu Y, Chen F, Zhang J, Luo J., Free PMC Article

    05/5/2018
    Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.

    Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.
    Gilistro E, de Turris V, Damizia M, Verrico A, Moroni S, De Santis R, Rosa A, Lavia P.

    04/21/2018
    Translocation of p53 is regulated by androgen-dependent sumoylation mediated by the G3BP2-interacting SUMO-E3 ligase, RanBP2. G3BP2 knockdown results in reduced tumor growth and increased nuclear p53 accumulation in mouse xenograft models of prostate cancer with or without long-term androgen deprivation.

    Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer.
    Ashikari D, Takayama K, Tanaka T, Suzuki Y, Obinata D, Fujimura T, Urano T, Takahashi S, Inoue S.

    12/2/2017
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