| Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis. | Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis.
Sajiir H, Wong KY, Müller A, Keshvari S, Burr L, Aiello E, Mezza T, Giaccari A, Sebastiani G, Dotta F, Ramm GA, Macdonald GA, McGuckin MA, Prins JB, Hasnain SZ., Free PMC Article | 06/6/2024 |
| Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE. | Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
Grk M, Miskovic R, Jeremic I, Basaric M, Dusanovic Pjevic M, Jekic B, Miljanovic D, Lazarevic I, Despotovic A, Cirkovic A, Banko A., Free PMC Article | 08/7/2023 |
| Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis. | Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis.
Abdelnabi MN, Flores Molina M, Soucy G, Quoc-Huy Trinh V, Bédard N, Mazouz S, Jouvet N, Dion J, Tran S, Bilodeau M, Estall JL, Shoukry NH., Free PMC Article | 11/26/2022 |
| Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C. | Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C.
de Brito RJVC, do Carmo RF, Silva BMS, Barbosa Júnior WL, Vasconcelos LRS, Pereira LMMB, Moura P. | 10/8/2022 |
| Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection. | Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection.
Albayrak N, Orte Cano C, Karimi S, Dogahe D, Van Praet A, Godefroid A, Del Marmol V, Grimaldi D, Bondue B, Van Vooren JP, Mascart F, Corbière V., Free PMC Article | 04/23/2022 |
| Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages. | Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
de Brito RJVC, do Carmo RF, Silva BMS, Costa ACS, Rocha SWS, Vasconcelos LRS, Pereira LMMB, de Moura PMMF. | 04/16/2022 |
| Increased expression of interleukin-22 and its receptor is relevant to poor prognosis in laryngeal squamous cell carcinoma: A case control trial. | Increased expression of interleukin-22 and its receptor is relevant to poor prognosis in laryngeal squamous cell carcinoma: A case control trial.
Ji W, Li J, Wang X, Gao D, Zhang T., Free PMC Article | 02/19/2022 |
| Targeting IL-22 and IL-22R protects against experimental osteoarthritis. | Targeting IL-22 and IL-22R protects against experimental osteoarthritis.
Yi C, Yi Y, Wei J, Jin Q, Li J, Sacitharan PK., Free PMC Article | 01/29/2022 |
| High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer. | High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer.
Nitschke K, Worst TS, von Rhade SM, Thaqi B, Neuberger M, Wessels F, Weis CA, Porubsky S, Gaiser T, Kriegmair M, von Hardenberg J, Weidenbusch M, Erben P, Nuhn P. | 01/8/2022 |
| Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis. | Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis.
Dinarte VRP, Silva WA Jr, Baccarin ARD, Tamashiro E, Valera FC, Anselmo-Lima WT., Free PMC Article | 09/25/2021 |
| Overexpression of IL22RA1 enhanced HTFs migration and proliferation, while miR-760 and miR-215-3p mimics reversed these promotive biological roles induced by IL22RA1. In conclusion, NR_003923 and IL22RA1 might contribute to glaucoma progression and be a novel and potential biomarkers and therapeutic targets for glaucoma | LncRNA NR_003923 promotes cell proliferation, migration, fibrosis, and autophagy via the miR-760/miR-215-3p/IL22RA1 axis in human Tenon's capsule fibroblasts.
Zhao Y, Zhang F, Pan Z, Luo H, Liu K, Duan X., Free PMC Article | 08/1/2020 |
| During influenza infection, IL22RA1 is induced in the lung. | IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1.
Hebert KD, Mclaughlin N, Zhang Z, Cipriani A, Alcorn JF, Pociask DA., Free PMC Article | 02/8/2020 |
| The IL22 gene promoter SNP rs2227473 G allele is a risk factor for intestinal tuberculosis. High IL-22 expression seems to be a protective factor for intestinal tuberculosis. IL-22R1 is not only highly expressed in epithelial cells but also, unexpectedly, expressed in Langhans giant cells, contradicting the previous view that IL-22R1 is expressed only in non-haematopoietic cells. | Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease.
Yu ZQ, Wang WF, Dai YC, Chen XC, Chen JY., Free PMC Article | 12/14/2019 |
| Study shows that high expression of IL22RA1 is associated with poor prognosis in pancreatic cancer. IL22 promotes pancreatic cancer stemness via IL22RA1/STAT3 signaling, identifying the mechanism of regulation of cancer stem cells by microenvironmental factors. Moreover, STAT3 activation is indispensable for the maintenance of IL22RA1-hi cells, both in the absence or presence of IL22. | IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer.
He W, Wu J, Shi J, Huo YM, Dai W, Geng J, Lu P, Yang MW, Fang Y, Wang W, Zhang ZG, Habtezion A, Sun YW, Xue J. | 08/3/2019 |
| found obvious statistic difference for the allele of early-onset PE/the genotype of late-onset preeclampsia (PE) and control subgroups for IL-22 rs2227485. IL-22 rs2227485 and IL-22RA1 rs3795299 may be associated with the development of PE in Chinese Han population. | Impact of IL-22 and IL-22 receptor alpha 1 polymorphisms on preeclampsia risk in Chinese Han women.
Niu Z, Zhao X, Liu H, Quan J, Lin Y, Li J, Wang J, Liu M, Song W, Chen A, Liu S. | 03/2/2019 |
| increased expression of IL-22Ralpha therefore promotes keratinocyte proliferation and pro-inflammatory cytokine production during UVB-induced skin inflammation, suggesting that UVB facilitates skin inflammation by increasing the responsiveness of keratinocytes to IL-22 | The pathogenic role of interleukin-22 and its receptor during UVB-induced skin inflammation.
Kim Y, Lee J, Kim J, Choi CW, Hwang YI, Kang JS, Lee WJ., Free PMC Article | 10/7/2017 |
| IL-22 and its receptor have a crucial role in the development and pathogenesis of uveitis by facilitating inflammatory cell infiltration. | The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis.
Kim Y, Kim TW, Park YS, Jeong EM, Lee DS, Kim IG, Chung H, Hwang YI, Lee WJ, Yu HG, Kang JS., Free PMC Article | 07/15/2017 |
| high expression profile of IL-22R1 in nonsmall cell lung cancer is an independent indicator of poor overall survival | Interleukin-22 receptor is overexpressed in nonsmall cell lung cancer and portends a poor prognosis.
Guillon A, Gueugnon F, Mavridis K, Dalloneau E, Jouan Y, Diot P, Heuzé-Vourc'h N, Courty Y, Si-Tahar M. | 02/18/2017 |
| phosphorylation of STAT3 and AKT was highly induced by treatment with IL-22 via IL-22R1. IL-22R1 was also consistently overexpressed in recurrent NSCLC tissues | Interleukin-22 promotes lung cancer cell proliferation and migration via the IL-22R1/STAT3 and IL-22R1/AKT signaling pathways.
Bi Y, Cao J, Jin S, Lv L, Qi L, Liu F, Geng J, Yu Y. | 02/18/2017 |
| These data suggest that imbalance of IL-22/IL-22R1 signaling regulates the pathogenesis of chronic rhinosinusitis with nasal polyps, including local eosinophilia, via alteration of MUC1 expression. | IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression.
Noyama Y, Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Makihara SI, Kanai K, Koyama T, Taniguchi M, Ishitoya JI, Kanda A, Kobayashi Y, Asako M, Tomoda K, Nishizaki K. | 01/28/2017 |
| FBXW12 functions as an E3 ligase constituent to ubiquitinate and degrade IL-22R and that therapeutic FBXW12 inhibition may enhance IL-22 signaling and bolster mucosal host defense and infection containment. | The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.
Franz J, Jerome J, Lear T, Gong Q, Weathington NM., Free PMC Article | 03/26/2016 |
| IL-22R1 is over-expressed in primary Sjogren's syndrome and Sjogren-associated non-Hodgkin lymphomas and is regulated by IL-18. | Interleukin (IL)-22 receptor 1 is over-expressed in primary Sjogren's syndrome and Sjögren-associated non-Hodgkin lymphomas and is regulated by IL-18.
Ciccia F, Guggino G, Rizzo A, Bombardieri M, Raimondo S, Carubbi F, Cannizzaro A, Sireci G, Dieli F, Campisi G, Giacomelli R, Cipriani P, De Leo G, Alessandro R, Triolo G., Free PMC Article | 10/3/2015 |
| IL-22 has restricted tissue specificity as its unique receptor IL-22R1 is exclusively expressed on epithelial and tissue cells, but not immune cells. | The role of the IL-22/IL-22R1 axis in cancer.
Lim C, Savan R. | 02/14/2015 |
| serum IL-22 levels are significantly higher in patients with pituitary macroadenomas than in healthy controls and IL-22R is variably expressed in both prolactinoma and non-functioing pituitary adenoma cells. | Increased serum interleukin-22 levels in patients with PRL-secreting and non-functioning pituitary macroadenomas.
Cannavo S, Ferrau F, Cotta OR, Saitta S, Barresi V, Cristani MT, Saija A, Ruggeri RM, Trimarchi F, Gangemi S. | 09/6/2014 |
| High expression of interleukin-22 receptor is associated with pancreatic ductal adenocarcinoma. | High expression of interleukin-22 and its receptor predicts poor prognosis in pancreatic ductal adenocarcinoma.
Wen Z, Liao Q, Zhao J, Hu Y, You L, Lu Z, Jia C, Wei Y, Zhao Y. | 09/6/2014 |