| RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability. | RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability.
Jalan M, Sharma A, Pei X, Weinhold N, Buechelmaier ES, Zhu Y, Ahmed-Seghir S, Ratnakumar A, Di Bona M, McDermott N, Gomez-Aguilar J, Anderson KS, Ng CKY, Selenica P, Bakhoum SF, Reis-Filho JS, Riaz N, Powell SN., Free PMC Article | 10/25/2024 |
| A glimpse into the hidden world of the flexible C-terminal protein binding domains of human RAD52. | A glimpse into the hidden world of the flexible C-terminal protein binding domains of human RAD52.
Struble LR, Lovelace JJ, Borgstahl GEO. | 09/9/2024 |
| Mechanism of single-stranded DNA annealing by RAD52-RPA complex. | Mechanism of single-stranded DNA annealing by RAD52-RPA complex.
Liang CC, Greenhough LA, Masino L, Maslen S, Bajrami I, Tuppi M, Skehel M, Taylor IA, West SC., Free PMC Article | 06/6/2024 |
| RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells. | RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells.
Audrey A, Kok YP, Yu S, de Haan L, van de Kooij B, van den Tempel N, Chen M, de Boer HR, van der Vegt B, van Vugt MATM. | 05/10/2024 |
| Human RAD52 stimulates the RAD51-mediated homology search. | Human RAD52 stimulates the RAD51-mediated homology search.
Muhammad AA, Basto C, Peterlini T, Guirouilh-Barbat J, Thomas M, Veaute X, Busso D, Lopez B, Mazon G, Le Cam E, Masson JY, Dupaigne P., Free PMC Article | 12/18/2023 |
| Elevated PAF1-RAD52 axis confers chemoresistance to human cancers. | Elevated PAF1-RAD52 axis confers chemoresistance to human cancers.
Rauth S, Ganguly K, Atri P, Parte S, Nimmakayala RK, Varadharaj V, Nallasamy P, Vengoji R, Ogunleye AO, Lakshmanan I, Chirravuri R, Bessho M, Cox JL, Foster JM, Talmon GA, Bessho T, Ganti AK, Batra SK, Ponnusamy MP., Free PMC Article | 10/5/2023 |
| Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination. | Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination.
Davó-Martínez C, Helfricht A, Ribeiro-Silva C, Raams A, Tresini M, Uruci S, van Cappellen WA, Taneja N, Demmers JAA, Pines A, Theil AF, Vermeulen W, Lans H., Free PMC Article | 09/26/2023 |
| Biochemical characterization of the RNA-binding and RNA-DNA strand exchange activities of the human RAD52 protein. | Biochemical characterization of the RNA-binding and RNA-DNA strand exchange activities of the human RAD52 protein.
Tsuchiya R, Saotome M, Kinoshita C, Kamoi K, Kagawa W., Free PMC Article | 07/6/2023 |
| DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells. | DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells.
Liu S, Wang Z, Shah SB, Chang CY, Ai M, Nguyen T, Xiang R, Wu X., Free PMC Article | 02/4/2023 |
| SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52. | SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52.
Diao Y, Li Y, Wang Z, Wang S, Li P, Kong B., Free PMC Article | 04/16/2022 |
| Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1alpha/miR-210/Rad52 pathway. | Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway.
Mo Y, Zhang Y, Zhang Y, Yuan J, Mo L, Zhang Q., Free PMC Article | 03/19/2022 |
| Rad52 mediates class-switch DNA recombination to IgD. | Rad52 mediates class-switch DNA recombination to IgD.
Xu Y, Zhou H, Post G, Zan H, Casali P., Free PMC Article | 03/5/2022 |
| BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52. | BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52.
Hatchi E, Goehring L, Landini S, Skourti-Stathaki K, DeConti DK, Abderazzaq FO, Banerjee P, Demers TM, Wang YE, Quackenbush J, Livingston DM., Free PMC Article | 01/8/2022 |
| RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3alpha Co-localization. | RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization.
Wang J, Oh YT, Li Z, Dou J, Tang S, Wang X, Wang H, Takeda S, Wang Y., Free PMC Article | 01/8/2022 |
| RAD52 aptamer regulates DNA damage repair and STAT3 in BRCA1/BRCA2deficient human acute myeloid leukemia. | RAD52 aptamer regulates DNA damage repair and STAT3 in BRCA1/BRCA2‑deficient human acute myeloid leukemia.
Xu Y, Lin Y, Luo Y, Yang Y, Long B, Fang Z, Liu L, Zhang J, Zhang X., Free PMC Article | 07/10/2021 |
| The RAD52 S346X variant reduces risk of developing breast cancer in carriers of pathogenic germline BRCA2 mutations. | The RAD52 S346X variant reduces risk of developing breast cancer in carriers of pathogenic germline BRCA2 mutations.
Adamson AW, Ding YC, Mendez-Dorantes C, Bailis AM, Stark JM, Neuhausen SL., Free PMC Article | 07/3/2021 |
| RAD52 variants influence NSCLC risk in the Chinese population in a high altitude area. | RAD52 variants influence NSCLC risk in the Chinese population in a high altitude area.
Li M, Chen R, Ji B, Fan C, Wang G, Yue C, Jin G., Free PMC Article | 06/5/2021 |
| The function of RAD52 N-terminal domain is essential for viability of BRCA-deficient cells. | The function of RAD52 N-terminal domain is essential for viability of BRCA-deficient cells.
Hanamshet K, Mazin AV., Free PMC Article | 01/16/2021 |
| Aberrant Expression of RAD52, Its Prognostic Impact in Rectal Cancer and Association with Poor Survival of Patients. | Aberrant Expression of RAD52, Its Prognostic Impact in Rectal Cancer and Association with Poor Survival of Patients.
Ho V, Chung L, Singh A, Lea V, Abubakar A, Lim SH, Chua W, Ng W, Lee M, Roberts TL, de Souza P, Lee CS., Free PMC Article | 01/9/2021 |
| Human RECQL4 represses the RAD52-mediated single-strand annealing pathway after ionizing radiation or cisplatin treatment. | Human RECQL4 represses the RAD52-mediated single-strand annealing pathway after ionizing radiation or cisplatin treatment.
Kohzaki M, Ootsuyama A, Sun L, Moritake T, Okazaki R. | 01/9/2021 |
| We show pronounced suppression of gene-conversion with increasing DNA double-strand breaks load that is not due to RAD51 availability and which is delimited but not defined by 53BP1 and RAD52. | Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52.
Mladenov E, Staudt C, Soni A, Murmann-Konda T, Siemann-Loekes M, Iliakis G., Free PMC Article | 03/21/2020 |
| Our work introduces for the first time RAD52 as another interacting partner of DSS1 and shows that both proteins are important players in the SSA and BIR pathways of DSB repair. | DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs.
Stefanovie B, Hengel SR, Mlcouskova J, Prochazkova J, Spirek M, Nikulenkov F, Nemecek D, Koch BG, Bain FE, Yu L, Spies M, Krejci L., Free PMC Article | 03/21/2020 |
| ROS-induced telomeric R-loops promote repair of telomeric DSBs through CSB-RAD52-POLD3-mediated BIR, a previously unknown pathway protecting telomeres from ROS. ROS-induced telomeric SSBs may not only give rise to DSBs indirectly, but also promote DSB repair by inducing R-loops, revealing an unexpected interplay between distinct ROS-induced DNA lesions. | An R-loop-initiated CSB-RAD52-POLD3 pathway suppresses ROS-induced telomeric DNA breaks.
Tan J, Duan M, Yadav T, Phoon L, Wang X, Zhang JM, Zou L, Lan L., Free PMC Article | 03/21/2020 |
| RAD52 and POLQ are both synthetic lethal with loss of the BRCA1 and BRCA2 tumor suppressor genes. Furthermore, RAD52 and POLQ have been implicated in chromosomal break repair events that use flanking repeats to restore the chromosome. Combined disruption of RAD52 and POLQ causes at least additive hypersensitivity to cisplatin and a synthetic reduction in replication fork restart velocity. | Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response.
Kelso AA, Lopezcolorado FW, Bhargava R, Stark JM., Free PMC Article | 01/11/2020 |
| lead to mitotic DNA synthesis (MiDAS) at telomeres mediated by RAD52 through its highly conserved N-terminal domain | Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52.
Min J, Wright WE, Shay JW., Free PMC Article | 09/14/2019 |