| Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/beta-catenin signaling. | Tumor-derived hypoxic small extracellular vesicles promote endothelial cell migration and tube formation via ALS2/Rab5/β-catenin signaling.
Silva P, Hernández N, Tapia H, Gaete-Ramírez B, Torres P, Flores T, Herrera D, Cáceres-Verschae A, Acuña RA, Varas-Godoy M, Torres VA. | 10/30/2024 |
| RAB5A in triple-negative breast cancer: a critical role in macrophage reshaping in an exosomal miR-21-dependent manner. | RAB5A in triple-negative breast cancer: a critical role in macrophage reshaping in an exosomal miR-21-dependent manner.
Qiao L, Dong C, Jia W, Sun G., Free PMC Article | 04/18/2024 |
| Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages. | Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages.
Wu KC, Condon ND, Hill TA, Reid RC, Fairlie DP, Lim J., Free PMC Article | 04/10/2024 |
| miR-451a suppresses the proliferation and migration of high-grade serous ovarian cancer by targeting RAB5A through the Ras/Raf/MEK/ERK pathway. | miR-451a suppresses the proliferation and migration of high-grade serous ovarian cancer by targeting RAB5A through the Ras/Raf/MEK/ERK pathway.
Liu S, Wang K, Zhao Z, Pang Y, Liu F, Wang P, Wang Z, Yang X. | 03/1/2024 |
| A genome-wide CRISPR/Cas9 screen identifies a role for Rab5A and early endosomes in hepatitis E virus replication. | A genome-wide CRISPR/Cas9 screen identifies a role for Rab5A and early endosomes in hepatitis E virus replication.
Oechslin N, Da Silva N, Ankavay M, Moradpour D, Gouttenoire J., Free PMC Article | 01/3/2024 |
| HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover. | HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover.
Khumukcham SS, Penugurti V, Bugide S, Dwivedi A, Kumari A, Kesavan PS, Kalali S, Mishra YG, Ramesh VA, Nagarajaram HA, Mazumder A, Manavathi B., Free PMC Article | 11/29/2023 |
| Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways. | Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways.
Zhao Z, Wei Z, Zheng J, Li Z, Zou H, Wen X, Li F, Wang X, Huang Q, Zeng H, Fan H, Cai X, Zhang J, Jia B, Huang A, Lu M, Lin Y., Free PMC Article | 11/1/2023 |
| Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner. | Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner.
Naslavsky N, Caplan S., Free PMC Article | 09/25/2023 |
| RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A-YTHDF2-dependent manner. | RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A-YTHDF2-dependent manner.
Shen D, Lin J, Xie Y, Zhuang Z, Xu G, Peng S, Tang G, Bai L, Zhu M, Zhang Y, Huang Z, Wang P, Liu X, Huang M, Luo Y, Wang X, Yu H., Free PMC Article | 05/25/2023 |
| Identification of Key Genes and miRNAs Affecting Osteosarcoma Based on Bioinformatics. | Identification of Key Genes and miRNAs Affecting Osteosarcoma Based on Bioinformatics.
Li L, Zhou X, Zhang W, Zhao R., Free PMC Article | 12/10/2022 |
| lncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma. | lncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma.
Wang X, Zheng S, Yang F, Zhang W, Zhao D, Xue X, Lin Q, He Y, Hu G, Hu Y., Free PMC Article | 05/7/2022 |
| CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity. | CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity.
Liu B, Lu Y, Zhang T, Yu X, Wang Q, Chi Y, Jin S, Cheng G., Free PMC Article | 02/26/2022 |
| Nectin stabilization at adherens junctions is counteracted by Rab5a-dependent endocytosis. | Nectin stabilization at adherens junctions is counteracted by Rab5a-dependent endocytosis.
Cervero P, Vrenken K, Klose M, Rehm K, Linder S. | 01/22/2022 |
| Long noncoding RNA CASC19 promotes glioma progression by modulating the miR4543p/RAB5A axis and is associated with unfavorable MRI features. | Long non‑coding RNA CASC19 promotes glioma progression by modulating the miR‑454‑3p/RAB5A axis and is associated with unfavorable MRI features.
Wu YJ, Yang QS, Chen H, Wang JT, Wang WB, Zhou L. | 11/22/2021 |
| Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond. | Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond.
Borchers AC, Langemeyer L, Ungermann C., Free PMC Article | 11/13/2021 |
| Propofol Represses Cell Growth and Metastasis by Modulating the Circular RNA Non-SMC Condensin I Complex Subunit G/MicroRNA-200a-3p/RAB5A Axis in Glioma. | Propofol Represses Cell Growth and Metastasis by Modulating the Circular RNA Non-SMC Condensin I Complex Subunit G/MicroRNA-200a-3p/RAB5A Axis in Glioma.
Zhang L, Chen H, Tian C, Zheng D. | 11/13/2021 |
| RAB5A effect on metastasis of hepatocellular carcinoma cell line via altering the pro-invasive content of exosomes. | RAB5A effect on metastasis of hepatocellular carcinoma cell line via altering the pro-invasive content of exosomes.
Gorji-Bahri G, Moghimi HR, Hashemi A. | 09/4/2021 |
| The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism. | The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism.
Buckles TC, Ohashi Y, Tremel S, McLaughlin SH, Pardon E, Steyaert J, Gordon MT, Williams RL, Falke JJ., Free PMC Article | 08/21/2021 |
| RAB5A promotes the formation of filopodia in pancreatic cancer cells via the activation of cdc42 and beta1-integrin. | RAB5A promotes the formation of filopodia in pancreatic cancer cells via the activation of cdc42 and β1-integrin.
Yuan Z, Wei W. | 04/24/2021 |
| Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes. | Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
Tremel S, Ohashi Y, Morado DR, Bertram J, Perisic O, Brandt LTL, von Wrisberg MK, Chen ZA, Maslen SL, Kovtun O, Skehel M, Rappsilber J, Lang K, Munro S, Briggs JAG, Williams RL., Free PMC Article | 04/13/2021 |
| Rab GTPase Mediating Regulation of NALP3 in Colorectal Cancer. | Rab GTPase Mediating Regulation of NALP3 in Colorectal Cancer.
Tezcan G, Garanina EE, Zhuravleva MN, Hamza S, Rizvanov AA, Khaiboullina SF., Free PMC Article | 03/28/2021 |
| Rac1-dependent endocytosis and Rab5-dependent intracellular trafficking are required by Enterovirus A71 and Coxsackievirus A10 to establish infections. | Rac1-dependent endocytosis and Rab5-dependent intracellular trafficking are required by Enterovirus A71 and Coxsackievirus A10 to establish infections.
Dun Y, Yan J, Wang M, Wang M, Liu L, Yu R, Zhang S. | 02/13/2021 |
| Protein diaphanous homolog 1 (Diaph1) promotes myofibroblastic activation of hepatic stellate cells by regulating Rab5a activity and TGFbeta receptor endocytosis. | Protein diaphanous homolog 1 (Diaph1) promotes myofibroblastic activation of hepatic stellate cells by regulating Rab5a activity and TGFβ receptor endocytosis.
Liu D, Fu X, Wang Y, Wang X, Wang H, Wen J, Kang N., Free PMC Article | 01/23/2021 |
| EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation. | EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation.
Tang J, Zhou B, Scott MJ, Chen L, Lai D, Fan EK, Li Y, Wu Q, Billiar TR, Wilson MA, Wang P, Fan J., Free PMC Article | 12/5/2020 |
| The study reveals an evolutionarily conserved role for the early endocytic marker Rab5 in cytokinetic abscission. | The exocyst complex and Rab5 are required for abscission by localizing ESCRT III subunits to the cytokinetic bridge.
Kumar H, Pushpa K, Kumari A, Verma K, Pergu R, Mylavarapu SVS., Free PMC Article | 07/11/2020 |