| RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors. | RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors.
Dou D, Aiken J, Holzbaur ELF., Free PMC Article | 03/22/2024 |
| Molecular and functional interactions of alpha-synuclein with Rab3a. | Molecular and functional interactions of alpha-synuclein with Rab3a.
Lv G, Ko MS, Das T, Eliezer D., Free PMC Article | 10/22/2022 |
| Unveiling the interaction between the molecular motor Myosin Vc and the small GTPase Rab3A. | Unveiling the interaction between the molecular motor Myosin Vc and the small GTPase Rab3A.
Dolce LG, Ohbayashi N, Silva DFCD, Ferrari AJR, Pirolla RAS, Schwarzer ACAP, Zanphorlin LM, Cabral L, Fioramonte M, Ramos CHI, Gozzo FC, Fukuda M, Giuseppe PO, Murakami MT. | 04/17/2021 |
| Rab27/Rabphilin3a/GRAB/Rab3 constitutes a signaling module in sperm exocytosis. | Grab recruitment by Rab27A-Rabphilin3a triggers Rab3A activation in human sperm exocytosis.
Quevedo MF, Bustos MA, Masone D, Roggero CM, Bustos DM, Tomes CN. | 09/14/2019 |
| Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release. | The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.
Quevedo MF, Lucchesi O, Bustos MA, Pocognoni CA, De la Iglesia PX, Tomes CN., Free PMC Article | 09/30/2017 |
| Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells. | Rab3a promotes brain tumor initiation and progression.
Kim JK, Lee SY, Park CW, Park SH, Yin J, Kim J, Park JB, Lee JY, Kim H, Kim SC. | 12/12/2015 |
| Data indicate that exocytic stimuli promote ADP ribosylation factor 6 (ARF6) activation, which accomplishes exocytosis by stimulating Rab3A GTP-Binding Protein. | ADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.
Pelletán LE, Suhaiman L, Vaquer CC, Bustos MA, De Blas GA, Vitale N, Mayorga LS, Belmonte SA., Free PMC Article | 06/27/2015 |
| Five compounds which possess good inhibitory activity and may act as potential high affinity inhibitors against Rab3A active site were identified | 3D structure generation, virtual screening and docking of human Ras-associated binding (Rab3A) protein involved in tumourigenesis.
Lodhi SS, Farmer R, Singh AK, Jaiswal YK, Wadhwa G. | 02/14/2015 |
| alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity | α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.
Chen RHC, Wislet-Gendebien S, Samuel F, Visanji NP, Zhang G, Marsilio D, Langman T, Fraser PE, Tandon A., Free PMC Article | 05/18/2013 |
| Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis. | Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis.
Bustos MA, Lucchesi O, Ruete MC, Mayorga LS, Tomes CN., Free PMC Article | 10/13/2012 |
| Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles | Myosin5a tail associates directly with Rab3A-containing compartments in neurons.
Wöllert T, Patel A, Lee YL, Provance DW Jr, Vought VE, Cosgrove MS, Mercer JA, Langford GM., Free PMC Article | 07/2/2011 |
| The maturation of amyloid precursor protein (APP) transport vesicles, including recruitment of conventional kinesin, requires Rab3A GTPase activity. | APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.
Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S., Free PMC Article | 01/21/2010 |
| Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis | Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis.
Branham MT, Bustos MA, De Blas GA, Rehmann H, Zarelli VE, Treviño CL, Darszon A, Mayorga LS, Tomes CN., Free PMC Article | 01/21/2010 |
| Rab3GEP has a role as the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes | Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.
Figueiredo AC, Wasmeier C, Tarafder AK, Ramalho JS, Baron RA, Seabra MC., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Variants in the RAB3A gene are not associated with mental retardation in the Chinese population.
Sun Y, Zhang F, Gao J, Gao X, Guo T, Shi Y, Tang W, Li S, Zheng Z, Zheng Y, Li X, Feng G, He L, Sun Y, Zhang F, Gao J, Gao X, Guo T, Shi Y, Tang W, Li S, Zheng Z, Zheng Y, Li X, Feng G, He L. | 03/13/2008 |
| Initiates exocytosis in acrosome when prenylated and activated with guanosine triphosphate (GTP). | Membrane-permeant Rab3A triggers acrosomal exocytosis in living human sperm.
Lopez CI, Belmonte SA, De Blas GA, Mayorga LS. | 01/21/2010 |
| a possible role in glomerulopathies | Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector rabphilin-3a.
Rastaldi MP, Armelloni S, Berra S, Li M, Pesaresi M, Poczewski H, Langer B, Kerjaschki D, Henger A, Blattner SM, Kretzler M, Wanke R, D'Amico G., Free PMC Article | 01/21/2010 |
| Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. | DNA variants in the human RAB3A gene are not associated with autism.
D'Adamo P, Bacchelli E, Blasi F, Lipp HP, Toniolo D, Maestrini E. | 01/21/2010 |
| Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association. | Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association.
Belmonte SA, López CI, Roggero CM, De Blas GA, Tomes CN, Mayorga LS. | 01/21/2010 |
| In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population. | Variants in the RAB3A gene are not associated with mental retardation in the Chinese population.
Sun Y, Zhang F, Gao J, Gao X, Guo T, Shi Y, Tang W, Li S, Zheng Z, Zheng Y, Li X, Feng G, He L, Sun Y, Zhang F, Gao J, Gao X, Guo T, Shi Y, Tang W, Li S, Zheng Z, Zheng Y, Li X, Feng G, He L. | 01/21/2010 |