| Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer. | Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer.
Jia Y, Yan Q, Zheng Y, Li L, Zhang B, Chang Z, Wang Z, Tang H, Qin Y, Guan XY., Free PMC Article | 10/8/2022 |
| Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma. | Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma.
Siril YJ, Kouketsu A, Saito H, Takahashi T, Kumamoto H. | 01/15/2022 |
| CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma. | CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma.
Yang G, Wang Y, Xiao J, Zhao F, Qiu J, Liu Y, Chen G, Cao Z, You L, Zheng L, Zhang T, Zhao Y. | 10/9/2021 |
| CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner. | CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner.
Zhai W, Ye X, Wang Y, Feng Y, Wang Y, Lin Y, Ding L, Yang L, Wang X, Kuang Y, Fu X, Eugene Chin Y, Jia B, Zhu B, Ren F, Chang Z., Free PMC Article | 09/25/2021 |
| RPRD1B is a potentially molecular target for diagnosis and prevention of human papillomavirus E6/E7 infection-induced cervical cancer: A case-control study. | RPRD1B is a potentially molecular target for diagnosis and prevention of human papillomavirus E6/E7 infection-induced cervical cancer: A case-control study.
Wen N, Bian L, Gon J, Meng Y. | 07/3/2021 |
| CREPT is required for murine stem cell maintenance during intestinal regeneration. | CREPT is required for murine stem cell maintenance during intestinal regeneration.
Yang L, Yang H, Chu Y, Song Y, Ding L, Zhu B, Zhai W, Wang X, Kuang Y, Ren F, Jia B, Wu W, Ye X, Wang Y, Chang Z., Free PMC Article | 01/23/2021 |
| MiR-139-5p inhibits the proliferation of gastric cancer cells by targeting Regulation of Nuclear Pre-mRNA Domain Containing 1B. | MiR-139-5p inhibits the proliferation of gastric cancer cells by targeting Regulation of Nuclear Pre-mRNA Domain Containing 1B.
Wenquan L, Hongqing X, Yuhua L, Lili W, Wang Z, Ziwei Z, Chuang W, Aizhen C, Xiaosong W, Bo W, Lin C. | 01/9/2021 |
| Overexpression of cell-cycle related and expression-elevated protein in tumor (CREPT) in malignant cervical cancer. | Overexpression of cell-cycle related and expression-elevated protein in tumor (CREPT) in malignant cervical cancer.
Wen N, Bian L, Gong J, Meng Y., Free PMC Article | 12/12/2020 |
| Crosstalk between RNA Pol II C-terminal domain acetylation and phosphorylation via RPRD1B protein and its isoforms has been reported. | Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M., Free PMC Article | 01/18/2020 |
| these results demonstrate that CREPT exerts an oncogenic role in glioma and its expression is regulated by miR-596. | CREPT promotes glioma cell proliferation and invasion by activating Wnt/β-catenin pathway and is a novel target of microRNA-596.
Wei M, Cao Y, Jia D, Zhao H, Zhang L. | 12/14/2019 |
| The study provides a mechanism by which gastric tumor cells maintain their high proliferation rate via coordination of AURKB and CREPT on the expression of CCNB1. | CREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer.
Ding L, Yang L, He Y, Zhu B, Ren F, Fan X, Wang Y, Li M, Li J, Kuang Y, Liu S, Zhai W, Ma D, Ju Y, Liu Q, Jia B, Sheng J, Chang Z., Free PMC Article | 11/30/2019 |
| Data show that miR-383 targeted the 3' untranslated regions (3'-UTR) of CREPT mRNA directly. | MicroRNA-383 acts as a tumor suppressor in colorectal cancer by modulating CREPT/RPRD1B expression.
Li J, Smith AR, Marquez RT, Li J, Li K, Lan L, Wu X, Zhao L, Ren F, Wang Y, Wang Y, Jia B, Xu L, Chang Z., Free PMC Article | 05/4/2019 |
| CREPT plays a pivotal oncogenic role in colorectal carcinogenesis through promoting Wnt/beta-catenin pathway via cooperating with p300. CREPT may serve as a prognostic biomarker of patients with colorectal cancer. | CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation.
Zhang Y, Wang S, Kang W, Liu C, Dong Y, Ren F, Wang Y, Zhang J, Wang G, To KF, Zhang X, Sung JJ, Chang Z, Yu J., Free PMC Article | 03/9/2019 |
| Aberrant overexpression of CREPT contributes to tumorigenesis of colorectal cancer by promoting cell proliferation and accelerating the cell cycle, and confers sensitivity to 5-fluorouracil. | Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil.
Kuang YS, Wang Y, Ding LD, Yang L, Wang Y, Liu SH, Zhu BT, Wang XN, Liu HY, Li J, Chang ZJ, Wang YY, Jia BQ., Free PMC Article | 08/25/2018 |
| Ccisplatin-induced peripheral neuropathy(isIPN) is associated with age, modifiable risk factors, and genetically determined expression level of RPRD1B Further study of implicated genes could elucidate the pathophysiologic underpinnings of CisIPN. | Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer.
Dolan ME, El Charif O, Wheeler HE, Gamazon ER, Ardeshir-Rouhani-Fard S, Monahan P, Feldman DR, Hamilton RJ, Vaughn DJ, Beard CJ, Fung C, Kim J, Fossa SD, Hertz DL, Mushiroda T, Kubo M, Einhorn LH, Cox NJ, Travis LB, Platinum Study Group., Free PMC Article | 07/21/2018 |
| CREPT is closely relevant to the proliferation of NSCLC cells. | Cell cycle-related and expression-elevated protein in tumor overexpression is associated with proliferation behaviors and poor prognosis in non-small-cell lung cancer.
Li W, Zheng G, Xia J, Yang G, Sun J, Wang X, Wen M, Sun Y, Zhang Z, Jin F., Free PMC Article | 04/21/2018 |
| Altogether, our results provided a novel insight into CREPT in regulating gastric cancer progression through apoptosis regulated by ROS/p53 pathways. | Inhibition of CREPT restrains gastric cancer growth by regulation of cycle arrest, migration and apoptosis via ROS-regulated p53 pathway.
Sun M, Si G, Sun HS, Si FC. | 03/17/2018 |
| Mechanistically, CREPT regulated beta-catenin/TCF4/cyclin D1 pathway in BC. In conclusion, the data suggested that miR-138/CREPT involved BC progression, providing potential therapeutic targets for BC. | CREPT regulated by miR-138 promotes breast cancer progression.
Liang Z, Feng Q, Xu L, Li S, Zhou L. | 10/21/2017 |
| Consistently, samples from oral squamous cell carcinoma (OSCC) patients exhibited a noticeably stronger CREPT expression than noncancerous samples. In contrast, knocking down of CREPT in OSCC cell lines significantly reduced proliferation, colony formation and migration as well as the expression of cyclin D1 and c-Myc, but promoted apoptosis. | Knocking-down of CREPT prohibits the progression of oral squamous cell carcinoma and suppresses cyclin D1 and c-Myc expression.
Ma J, Ren Y, Zhang L, Kong X, Wang T, Shi Y, Bu R., Free PMC Article | 09/9/2017 |
| In addition, CREPT overexpression significantly promoted tumor growth in vivo. Mechanism study showed that CREPT may regulate cell proliferation and cell cycle through the regulation on cyclin D3, CDK4 and CDK6. | High expression of CREPT promotes tumor growth and is correlated with poor prognosis in colorectal cancer.
Zheng G, Li W, Zuo B, Guo Z, Xi W, Wei M, Chen P, Wen W, Yang AG. | 06/3/2017 |
| a detailed description of proteins associating with K-H/RPRD1B in higher-order protein complexes is required to further elucidate its role in various cellular processes | The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair.
Patidar PL, Motea EA, Fattah FJ, Zhou Y, Morales JC, Xie Y, Garner HR, Boothman DA., Free PMC Article | 07/30/2016 |
| CREPT displays unique immunostaining for retroperitoneal leiomyosarcoma tissue and can be used to supplement other currently available markers. | CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma.
She Y, Liang J, Chen L, Qiu Y, Liu N, Zhao X, Huang X, Wang Y, Ren F, Chang Z, Li P., Free PMC Article | 07/25/2015 |
| study suggests that CREPT acts as an activator to promote transcriptional activity of the beta-catenin.TCF4 complex in response to Wnt signaling. | CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the β-catenin·TCF4 transcriptional activity in response to Wnt signaling.
Zhang Y, Liu C, Duan X, Ren F, Li S, Jin Z, Wang Y, Feng Y, Liu Z, Chang Z., Free PMC Article | 12/20/2014 |
| RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2. | RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WW, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J, Greenblatt JF., Free PMC Article | 10/11/2014 |
| RPRD1B overexpression promotes tumor growth and accelerates cell cycle progression. | RPRD1B promotes tumor growth by accelerating the cell cycle in endometrial cancer.
Wang Y, Qiu H, Hu W, Li S, Yu J. | 09/27/2014 |