| Biallelic Variants in KIF17 Associated with Microphthalmia and Coloboma Spectrum. | Biallelic Variants in KIF17 Associated with Microphthalmia and Coloboma Spectrum.
Riva A, Gambadauro A, Dipasquale V, Casto C, Ceravolo MD, Accogli A, Scala M, Ceravolo G, Iacomino M, Zara F, Striano P, Cuppari C, Di Rosa G, Cutrupi MC, Salpietro V, Chimenz R., Free PMC Article | 05/29/2021 |
| The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport. | Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.
Milic B, Andreasson JOL, Hogan DW, Block SM., Free PMC Article | 06/2/2018 |
| In mammalian cells, KIF17 is dispensable for ciliogenesis and IFT-B trafficking but requires IFT-B, as well as its NLS, for its ciliary entry across the permeability barrier located at the ciliary base. | Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.
Funabashi T, Katoh Y, Michisaka S, Terada M, Sugawa M, Nakayama K., Free PMC Article | 09/23/2017 |
| The first evidence of an interaction between septins and a nonmitotic kinesin is provided and it is suggested that SEPT9 modulates the interactions of KIF17 with membrane cargo. | Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport.
Bai X, Karasmanis EP, Spiliotis ET., Free PMC Article | 01/14/2017 |
| KIF17 can modify RhoA-GTPase signaling to influence junctional actin and the stability of the apical junctional complex of epithelial cells. | KIF17 regulates RhoA-dependent actin remodeling at epithelial cell-cell adhesions.
Acharya BR, Espenel C, Libanje F, Raingeaud J, Morgan J, Jaulin F, Kreitzer G., Free PMC Article | 12/17/2016 |
| Expression of KIF17 in schizophrenic postmortem brains was significantly lower than controls. Both genotypic distribution and allelic frequency of rs2296225 polymorphism were significantly different between the chronic schizophrenia subjects and controls. | A decrease in protein level and a missense polymorphism of KIF17 are associated with schizophrenia.
Ratta-Apha W, Mouri K, Boku S, Ishiguro H, Okazaki S, Otsuka I, Sora I, Arinami T, Shirakawa O, Hishimoto A. | 07/16/2016 |
| although EB1 and KIF17-Tail may coordinate KIF17 catalytic activity, our data reveal a novel and direct role for KIF17 in regulating MT dynamics. | Direct regulation of microtubule dynamics by KIF17 motor and tail domains.
Acharya BR, Espenel C, Kreitzer G., Free PMC Article | 01/25/2014 |
| This study suggested that disruption of KIF17, although rare, could result in a schizophrenia phenotype and emphasize the possible involvement of rare de novo mutations in this disorder. | De novo truncating mutation in Kinesin 17 associated with schizophrenia.
Tarabeux J, Champagne N, Brustein E, Hamdan FF, Gauthier J, Lapointe M, Maios C, Piton A, Spiegelman D, Henrion E, Synapse to Disease Team, Millet B, Rapoport JL, Delisi LE, Joober R, Fathalli F, Fombonne E, Mottron L, Forget-Dubois N, Boivin M, Michaud JL, Lafrenière RG, Drapeau P, Krebs MO, Rouleau GA. | 01/15/2011 |
| Depletion of KIF17 from cells growing in three-dimensional matrices results in aberrant epithelial cysts that fail to generate a single central lumen and to polarize apical markers. | KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC.
Jaulin F, Kreitzer G., Free PMC Article | 09/13/2010 |
| Data show that the homodimeric kinesin-2 motor KIF17 is kept in an inactive state in the absence of cargo, and define two molecular mechanisms that contribute to autoinhibition of KIF17. | Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms.
Hammond JW, Blasius TL, Soppina V, Cai D, Verhey KJ., Free PMC Article | 07/12/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
Aston KI, Krausz C, Laface I, Ruiz-Castané E, Carrell DT. | 06/30/2010 |
| The intense placental expression of KIFC1 in syncytiotrophoblast and KIF17 in vascular endothelium suggests that both proteins might be important in a cargo-transport system. KIFC1 and KIF17 expression are increased of both in preeclamptia and diabetes. | The presence of kinesin superfamily motor proteins KIFC1 and KIF17 in normal and pathological human placenta.
Sati L, Seval-Celik Y, Unek G, Korgun ET, Demir R. | 02/8/2010 |
| KIF17b serves as a molecular motor component of a TB-RBP-mouse ribonucleoprotein complex transporting a group of specific CREM-regulated mRNAs. | The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells.
Chennathukuzhi V, Morales CR, El-Alfy M, Hecht NB., Free PMC Article | 01/21/2010 |