| Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population. | Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population.
Aljaibeji H, Heydarpour M, Stanton AM, Williams JS, Pojoga LH, Romero JR, Williams GH., | 04/22/2024 |
| MALAT1 DEREPRESSES MIR-433-3P-MEDIATED RPTOR SUPPRESSION TO IMPAIR AUTOPHAGY AND DRIVE PYROPTOSIS IN ENDOTOXEMIA. | MALAT1 DEREPRESSES MIR-433-3P-MEDIATED RPTOR SUPPRESSION TO IMPAIR AUTOPHAGY AND DRIVE PYROPTOSIS IN ENDOTOXEMIA.
Wu K, Yu X, Wang Y, Li X, An Y, Zhao Z, Ma L. | 04/5/2024 |
| Raptor mediates the selective inhibitory effect of cardamonin on RRAGC-mutant B cell lymphoma. | Raptor mediates the selective inhibitory effect of cardamonin on RRAGC-mutant B cell lymphoma.
Liu Y, Zhu Y, Chen H, Zhou J, Niu P, Shi D., Free PMC Article | 09/29/2023 |
| Association of PI3K/AKT/mTOR pathway autophagy-related gene polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population. | Association of PI3K/AKT/mTOR pathway autophagy-related gene polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population.
He J, Liu S, Guo X, Zhang F, Fan Y, Wu L, Takiff HE, Zhao Y., Free PMC Article | 08/7/2023 |
| RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia-reperfusion-induced injury. | RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia-reperfusion-induced injury.
Wang N, Wang L, Li C, Rao P, Wang X, Xu Y, Yang L, Sun L, Lu D. | 02/17/2023 |
| RPTOR methylation in the peripheral blood and breast cancer in the Chinese population. | RPTOR methylation in the peripheral blood and breast cancer in the Chinese population.
Yin Y, Lei S, Li L, Yang X, Yin Q, Xu T, Zhou W, Li H, Gu W, Ma F, Yang R, Zhang Z. | 05/14/2022 |
| The Association between the Plasma Sugar and Lipid Profile with the Gene Expression of the Regulatory Protein of mTOR (Raptor) in Patients with Rheumatoid Arthritis. | The Association between the Plasma Sugar and Lipid Profile with the Gene Expression of the Regulatory Protein of mTOR (Raptor) in Patients with Rheumatoid Arthritis.
Samimi Z, Izadpanah A, Feizollahi P, Roghani SA, Assar S, Zafari P, Taghadosi M. | 12/18/2021 |
| Different Role of Raptor and Rictor in Regulating Rasfonin-Induced Autophagy and Apoptosis in Renal Carcinoma Cells. | Different Role of Raptor and Rictor in Regulating Rasfonin-Induced Autophagy and Apoptosis in Renal Carcinoma Cells.
Hou B, Liu S, Li E, Jiang X. | 06/26/2021 |
| The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. | The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.
Böhm R, Imseng S, Jakob RP, Hall MN, Maier T, Hiller S. | 06/26/2021 |
| Raptor and rictor expression in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma. | Raptor and rictor expression in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma.
Kondo S, Hirakawa H, Ikegami T, Uehara T, Agena S, Uezato J, Kinjyo H, Kise N, Yamashita Y, Tanaka K, Hasegawa N, Kiyuna A, Maeda H, Suzuki M, Gahana A., Free PMC Article | 05/15/2021 |
| RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1. | RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1.
Wang T, Zhang WS, Wang ZX, Wu ZW, Du BB, Li LY, Chen YF, Yang XF, Hao XY, Guo TK., Free PMC Article | 04/24/2021 |
| Knocking down raptor in human keratinocytes affects ornithine decarboxylase in a post-transcriptional Manner following ultraviolet B exposure. | Knocking down raptor in human keratinocytes affects ornithine decarboxylase in a post-transcriptional Manner following ultraviolet B exposure.
Stump CL, Feehan RP, Jordan T, Shantz LM, Nowotarski SL. | 11/21/2020 |
| Upregulation of Akt/Raptor signaling is associated with rapamycin resistance of breast cancer cells. | Upregulation of Akt/Raptor signaling is associated with rapamycin resistance of breast cancer cells.
Shchegolev Y, Sorokin D, Scherbakov A, Shunaev A, Andreeva O, Mikhaevich E, Gudkova M, Bure I, Berstein L, Nemtsova M, Krasil'nikov M. | 10/24/2020 |
| Expression of Raptor and Rictor and their relationships with angiogenesis in colorectal cancer. | Expression of Raptor and Rictor and their relationships with angiogenesis in colorectal cancer.
Wen FF, Li XY, Li YY, He S, Xu XY, Liu YH, Liu L, Wu SH. | 09/12/2020 |
| ryo-electron microscopy structure of RagA/RagC in complex with mTORC1 shows the details of RagA/RagC binding to the RAPTOR subunit of mTORC1 and explains why only the RagAGTP/RagCGDP nucleotide state binds mTORC1 | Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Anandapadamanaban M, Masson GR, Perisic O, Berndt A, Kaufman J, Johnson CM, Santhanam B, Rogala KB, Sabatini DM, Williams RL., Free PMC Article | 05/2/2020 |
| The Raptor alpha-solenoid directly detects the nucleotide state of RagA while the Raptor "claw" threads between the GTPase domains to detect that of RagC. Mutations that disrupted Rag-Raptor binding inhibited mTORC1 lysosomal localization and signaling. | Structural basis for the docking of mTORC1 on the lysosomal surface.
Rogala KB, Gu X, Kedir JF, Abu-Remaileh M, Bianchi LF, Bottino AMS, Dueholm R, Niehaus A, Overwijn D, Fils AP, Zhou SX, Leary D, Laqtom NN, Brignole EJ, Sabatini DM., Free PMC Article | 04/25/2020 |
| Here, the authors report that G-protein coupled receptors (GPCRs) paired to Galphas proteins increase cyclic adenosine 3'5' monophosphate (cAMP) to activate protein kinase A (PKA) and inhibit mTORC1. Mechanistically, PKA phosphorylates the mTORC1 component Raptor on Ser 791, leading to decreased mTORC1 activity. | GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL., Free PMC Article | 02/29/2020 |
| Persistent mTORC1 deficiency in macrophages contributes to the progression of Nonalcoholic Steatohepatitis. | Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis.
Liu W, Ye C, Cheng Q, Zhang X, Yao L, Li Q, Huang J, Liu Y, Zou Z, Wang H, Yan J, Zhu Y, Wang C, Ai D., Free PMC Article | 05/4/2019 |
| Study found that nuclear expression of raptor in luminal A-like breast tumors predicted a group of patients with good prognosis but with no clear benefit of tamoxifen treatment. Additionally, study found co-localization of raptor and estrogen receptor-alpha (ERalpha) upon estrogen stimulation in ERalpha-positive, but not in ERalpha-negative breast cancer cells. | Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer.
Bostner J, Alayev A, Berman AY, Fornander T, Nordenskjöld B, Holz MK, Stål O., Free PMC Article | 03/23/2019 |
| Study shows that USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors. USP9X is the first deubiquitylating enzyme shown to stabilize RAPTOR. | USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors.
Bridges CR, Tan MC, Premarathne S, Nanayakkara D, Bellette B, Zencak D, Domingo D, Gecz J, Murtaza M, Jolly LA, Wood SA., Free PMC Article | 09/1/2018 |
| Results suggest that RPTOR mediates, at least partially, the resistance to EGFR inhibition in triple-negative breast cancer cells. | Inhibition of RPTOR overcomes resistance to EGFR inhibition in triple-negative breast cancer cells.
You KS, Yi YW, Kwak SJ, Seong YS. | 09/1/2018 |
| data reveal that RAPTOR up-regulation contributes to PI3K-mTOR inhibitor resistance, and suggest that RAPTOR expression should be included in the pharmacodynamic assessment of mTOR kinase inhibitor trials | RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition.
Earwaker P, Anderson C, Willenbrock F, Harris AL, Protheroe AS, Macaulay VM., Free PMC Article | 03/17/2018 |
| Hypomethylation of CpG sites in RPTOR, MGRN1 and RAPSN in blood is associated with breast cancer. | DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.
Tang Q, Holland-Letz T, Slynko A, Cuk K, Marme F, Schott S, Heil J, Qu B, Golatta M, Bewerunge-Hudler M, Sutter C, Surowy H, Wappenschmidt B, Schmutzler R, Hoth M, Bugert P, Bartram CR, Sohn C, Schneeweiss A, Yang R, Burwinkel B., Free PMC Article | 02/10/2018 |
| RPTOR (regulatory associated protein of mTOR, complex 1) is a novel target of miR-155 in CF lung epithelial cells. The suppression of RPTOR expression and subsequent activation of TGF-beta signaling resulted in the induction of fibrosis by elevating connective tissue growth factor (CTGF) abundance in CF lung epithelial cells. | RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF.
Tsuchiya M, Kalurupalle S, Kumar P, Ghoshal S, Zhang Y, Lehrmann E, Becker KG, Gorospe M, Biswas R., Free PMC Article | 10/21/2017 |
| Data show that mTOR protein forms a complex with Raptor and estrogen receptor-alpha (ERalpha). | mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation.
Alayev A, Salamon RS, Berger SM, Schwartz NS, Cuesta R, Snyder RB, Holz MK., Free PMC Article | 09/16/2017 |