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    PTK2 protein tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 5747, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway.

    DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway.
    Tang ZY, Wang XM, Xu CW, Sun QQ, Hua YX, Zhou QY, Hu HY, Liu SB, Guo YJ, Ao L, Che X, Zhang XC, Heger M, Zheng X, Liu AJ, Wang Q, Zhan ZJ, Cheng SQ, Pan WW., Free PMC Article

    10/7/2024
    Inhibition of Integrin-Associated Kinases FAK and ILK on the In Vitro Model of Skin Wound Healing.

    Inhibition of Integrin-Associated Kinases FAK and ILK on the In Vitro Model of Skin Wound Healing.
    Bildyug N.

    09/23/2024
    Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population.

    Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population.
    Porter T, Del Valle MM, Kucheryavykh L., Free PMC Article

    08/28/2024
    Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium hydrogen exchanger 1.

    Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium hydrogen exchanger 1.
    Chen A, Zhang J, Yan Z, Lu Y, Chen W, Sun Y, Gu Q, Li F, Yang Y, Qiu S, Lin X, Zhang D, Teng J, Fang Y, Shen B, Song N, Ding X., Free PMC Article

    08/26/2024
    Analysis of Expression of the ANG1, CaSR and FAK Proteins in Uterine Fibroids.

    Analysis of Expression of the ANG1, CaSR and FAK Proteins in Uterine Fibroids.
    Markowska A, de Mezer M, Kurzawa P, Bednarek W, Gryboś A, Krzyżaniak M, Markowska J, Gryboś M, Żurawski J., Free PMC Article

    08/9/2024
    Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal Homeostasis and Innate Immunity Crosstalk.

    Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal Homeostasis and Innate Immunity Crosstalk.
    Brown ND, Vomhof-DeKrey EE., Free PMC Article

    08/1/2024
    FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro.

    FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro.
    Yeung V, Sriram S, Tran JA, Guo X, Hutcheon AEK, Zieske JD, Karamichos D, Ciolino JB., Free PMC Article

    07/26/2024
    FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity.

    FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity.
    Akhter MZ, Yazbeck P, Tauseef M, Anwar M, Hossen F, Datta S, Vellingiri V, Chandra Joshi J, Toth PT, Srivastava N, Lenzini S, Zhou G, Lee J, Jain MK, Shin JW, Mehta D., Free PMC Article

    07/11/2024
    T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway.

    T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway.
    Park SY, Choi H, Choi SM, Wang S, Shim S, Jun W, Lee J, Chung JW., Free PMC Article

    07/5/2024
    The dysadherin/FAK axis promotes individual cell migration in colon cancer.

    The dysadherin/FAK axis promotes individual cell migration in colon cancer.
    Lee CJ, Jang TY, Kim JH, Lim S, Lee S, Nam JS., Free PMC Article

    06/12/2024
    HuR-induced circ_0082319 contributes to hepatocellular carcinoma by elevating PTK2 through miR-505-3p.

    HuR-induced circ_0082319 contributes to hepatocellular carcinoma by elevating PTK2 through miR-505-3p.
    Qin C, Liu S, Chen W, Xue D, Guo T, Wu B.

    05/9/2024
    Effect of Focal Adhesion Kinase and Vinculin Expression on Migration Parameters of Normal and Tumor Epitheliocytes.

    Effect of Focal Adhesion Kinase and Vinculin Expression on Migration Parameters of Normal and Tumor Epitheliocytes.
    Solomatina ES, Kovaleva AV, Tvorogova AV, Vorobjev IA, Saidova AA.

    05/7/2024
    A decrease in integrin alpha5beta1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.

    A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.
    Xue M, Xing L, Yang Y, Shao M, Liao F, Xu F, Chen Y, Wang S, Chen B, Yao C, Gu G, Tong C., Free PMC Article

    03/29/2024
    ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.

    ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
    Saikia BB, Bhowmick S, Malat A, Preetha Rani MR, Thaha A, Abdul-Muneer PM., Free PMC Article

    03/21/2024
    FAK mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation by modulating mitochondrial transcription termination factor 1/cyclin D1.

    FAK mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation by modulating mitochondrial transcription termination factor 1/cyclin D1.
    Lin C, Yang H, Luo Q, Liu Q., Free PMC Article

    03/19/2024
    ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.

    ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling.
    Cheng S, Li M, Zheng W, Li C, Hao Z, Dai Y, Wang J, Zhuo J, Zhang L.

    03/14/2024
    THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway.

    THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway.
    Xu Z, Lu J, Gao S, Rui YN., Free PMC Article

    03/13/2024
    Exploring the therapeutic potential of focal adhesion kinase inhibition in overcoming chemoresistance in pancreatic ductal adenocarcinoma.

    Exploring the therapeutic potential of focal adhesion kinase inhibition in overcoming chemoresistance in pancreatic ductal adenocarcinoma.
    Scianò F, Terrana F, Pecoraro C, Parrino B, Cascioferro S, Diana P, Giovannetti E, Carbone D.

    02/5/2024
    DPP-4 exacerbates LPS-induced endothelial cells inflammation via integrin-alpha5beta1/FAK/AKT signaling.

    DPP-4 exacerbates LPS-induced endothelial cells inflammation via integrin-α5β1/FAK/AKT signaling.
    Liu C, Xu J, Fan J, Liu C, Xie W, Kong H.

    02/4/2024
    ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma.

    ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma.
    Wang Y, Shen N, Yang Y, Xia Y, Zhang W, Lu Y, Wang Z, Yang Z, Wang Z., Free PMC Article

    01/30/2024
    VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner.

    VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner.
    Zhou Q, Qi F, Zhou C, Ji J, Jiang J, Wang C, Zhao Q, Jin Y, Wu J, Cai Q, Tian H, Zhang J., Free PMC Article

    01/15/2024
    High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast.

    High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast.
    Xie D, Wang Z, Sun B, Qu L, Zeng M, Feng L, Guo M, Wang G, Hao J, Zhou G.

    12/22/2023
    FAK scaffolds immune escape in pancreatic cancer.

    FAK scaffolds immune escape in pancreatic cancer.
    Blanco-Gomez A, Jorgensen C.

    12/20/2023
    FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer.

    FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer.
    Canel M, Sławińska AD, Lonergan DW, Kallor AA, Upstill-Goddard R, Davidson C, von Kriegsheim A, Biankin AV, Byron A, Alfaro J, Serrels A., Free PMC Article

    12/20/2023
    PTK2-associated gene signature could predict the prognosis of IPF.

    PTK2-associated gene signature could predict the prognosis of IPF.
    Feng A, Caro YM, Gardner C, Grischo G, Liang Y, Wickremasinghe PD, Polmann M, Kala M, Marlowe T, Black SM, Knox KS, Wang T., Free PMC Article

    12/15/2023
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