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    MIR522 microRNA 522 [ Homo sapiens (human) ]

    Gene ID: 574495, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    miR-522 regulates cell proliferation, migration, invasion capacities and acts as a potential biomarker to predict prognosis in triple-negative breast cancer.

    miR-522 regulates cell proliferation, migration, invasion capacities and acts as a potential biomarker to predict prognosis in triple-negative breast cancer.
    Wang W, Zhang W, Wu J, Zhou Z, Ma J.

    08/6/2022
    Long noncoding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR522.

    Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522.
    Qian HG, Wu Q, Wu JH, Tian XY, Xu W, Hao CY., Free PMC Article

    03/12/2022
    LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis.

    LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis.
    Zhou Y, Li K, Zou X, Hua Z, Wang H, Bian W, Wang H, Chen F, Dai T., Free PMC Article

    02/19/2022
    rs6426881 in the 3'-UTR of PBX1 is involved in breast and gastric cancers via altering the binding potential of miR-522-3p.

    rs6426881 in the 3'-UTR of PBX1 is involved in breast and gastric cancers via altering the binding potential of miR-522-3p.
    Mohammadi M, Salehzadeh A, Talesh Sasani S, Tarang A.

    01/15/2022
    Targeting of DeltaNp63alpha by miR-522 promotes the migration of breast epithelial cells.

    Targeting of ΔNp63α by miR-522 promotes the migration of breast epithelial cells.
    Dong Y, Long J, Luo X, Xie G, Xiao ZJ, Tong Y., Free PMC Article

    12/18/2021
    MicroRNA-522-3p plays an oncogenic role in glioblastoma through activating Wnt/beta-catenin signaling pathway via targeting SFRP2.

    MicroRNA-522-3p plays an oncogenic role in glioblastoma through activating Wnt/β-catenin signaling pathway via targeting SFRP2.
    Zhang L, Zhang P, Tan Y, Feng Q, Zhao R.

    12/4/2021
    Long non-coding RNA HCG11 sponging miR-522-3p inhibits the tumorigenesis of non-small cell lung cancer by upregulating SOCS5.

    Long non-coding RNA HCG11 sponging miR-522-3p inhibits the tumorigenesis of non-small cell lung cancer by upregulating SOCS5.
    Fan G, Jiao J, Shen F, Ren Q, Wang Q, Chu F., Free PMC Article

    08/14/2021
    Results suggested that miR-522 regulated the expression of proinflammatory cytokines and MMPs partly via targeting SOCS3 in RA synovial fibroblasts, which may contribute to pathogenesis of RA.

    miR-522 Modulated the Expression of Proinflammatory Cytokines and Matrix Metalloproteinases Partly via Targeting Suppressor of Cytokine Signaling 3 in Rheumatoid Arthritis Synovial Fibroblasts.
    Wang X, Si X, Sun J, Yue L, Wang J, Yu Z.

    04/28/2018
    The data indicate that HMGB1-miR-522-3p-PTGR1 axis may be involved in the abnormal resolution of inflammation and suggest that this mechanism might be a target for modulation of chronic inflammatory disorder.

    Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis.
    Kang GJ, Lee HJ, Byun HJ, Kim EJ, Kim HJ, Park MK, Lee CH.

    10/7/2017
    DKK1 (dickkopf-1) and SFRP2 (secreted frizzled-related protein 2) were the targets of miR-522 in hepatocellular carcinoma

    miR-522 contributes to cell proliferation of hepatocellular carcinoma by targeting DKK1 and SFRP2.
    Zhang H, Yu C, Chen M, Li Z, Tian S, Jiang J, Sun C.

    02/18/2017
    MiR522 was overexpressed in the HT29/DOX cells, the protein expression levels of ABCB5 were downregulated.

    MicroRNA-522 reverses drug resistance of doxorubicin-induced HT29 colon cancer cell by targeting ABCB5.
    Yang G, Jiang O, Ling D, Jiang X, Yuan P, Zeng G, Zhu J, Tian J, Weng Y, Wu D.

    05/14/2016
    Glioblastoma tumor cell proliferation was promoted through miR-522.

    MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression.
    Zhang S, Zhang H, Zhu J, Zhang X, Liu Y.

    01/16/2016
    miR-522 regulates cell proliferation, detachment, migration, and epithelial-mesenchymal transition.

    Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522.
    Tan SM, Kirchner R, Jin J, Hofmann O, McReynolds L, Hide W, Lieberman J.

    05/30/2015
    These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site

    The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site.
    Richardson K, Louie-Gao Q, Arnett DK, Parnell LD, Lai CQ, Davalos A, Fox CS, Demissie S, Cupples LA, Fernandez-Hernando C, Ordovas JM., Free PMC Article

    03/16/2012
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