| this study shows that Tmem27-mediated cross-presentation supports intrahepatic adaptive antiviral immune responses and may lead to insights into the nature of how the liver acts as a primary site of CD8+ T cell activation | Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Dolina JS, Cechova S, Rudy CK, Sung SJ, Tang WW, Lee J, Hahn YS, Le TH. | 09/16/2017 |
| analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin | Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.
Fairweather SJ, Bröer A, Subramanian N, Tumer E, Cheng Q, Schmoll D, O'Mara ML, Bröer S., Free PMC Article | 01/16/2016 |
| Collectrin is a consequential link between the transport of l-arginine and endothelial nitric oxide synthase uncoupling in hypertension. | Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction.
Cechova S, Zeng Q, Billaud M, Mutchler S, Rudy CK, Straub AC, Chi L, Chan FR, Hu J, Griffiths R, Howell NL, Madsen K, Jensen BL, Palmer LA, Carey RM, Sung SS, Malakauskas SM, Isakson BE, Le TH. | 02/1/2014 |
| Collectrin and ACE2 in renal and intestinal amino acid transport. | Collectrin and ACE2 in renal and intestinal amino acid transport.
Singer D, Camargo SM. | 02/18/2012 |
| These data indicate the involvement of mitochondrial TCA cycle intermediates, distal to pyruvate, in the regulation of collectrin protein expression in beta-cells. | Glucose enhances collectrin protein expression in insulin-producing MIN6 beta cells.
Saisho K, Fukuhara A, Yasuda T, Sato Y, Fukui K, Iwahashi H, Imagawa A, Hatta M, Shimomura I, Yamagata K. | 01/21/2010 |
| In contrast to its association with ACE2 observed in Xenopus oocytes, experiments with ace2 and collectrin null mice demonstrate that in vivo it is Collectrin, a smaller homologue of ACE2, that is required for functional expression of XT2 in kidney. | Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3.
Singer D, Camargo SM, Huggel K, Romeo E, Danilczyk U, Kuba K, Chesnov S, Caron MG, Penninger JM, Verrey F., Free PMC Article | 01/21/2010 |
| Collectrin-deficient mice activate a number of adaptive mechanisms to defend energy homeostasis in the setting of ongoing nutrient losses. | Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.
Malakauskas SM, Kourany WM, Zhang XY, Lu D, Stevens RD, Koves TR, Hohmeier HE, Muoio DM, Newgard CB, Le TH., Free PMC Article | 01/21/2010 |
| functional association of mutant B(0)AT1 transporters with ACE2 and collectrin in intestine and kidney, respectively, participates in the phenotypic heterogeneity of Hartnup disorder | Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.
Camargo SM, Singer D, Makrides V, Huggel K, Pos KM, Wagner CA, Kuba K, Danilczyk U, Skovby F, Kleta R, Penninger JM, Verrey F., Free PMC Article | 01/21/2010 |
| Collectrin has a role in amino acid transpor in the kidney [review] | Collectrin and the kidney.
Mount DB. | 01/21/2010 |
| data identify collectrin as a key regulator of renal amino acid uptake | Essential role for collectrin in renal amino acid transport.
Danilczyk U, Sarao R, Remy C, Benabbas C, Stange G, Richter A, Arya S, Pospisilik JA, Singer D, Camargo SM, Makrides V, Ramadan T, Verrey F, Wagner CA, Penninger JM. | 01/21/2010 |
| Our data suggest that collectrin is a novel mediator of renal amino acid transport and may provide further insight into the pathogenesis of a number of human disease correlates. | Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin.
Malakauskas SM, Quan H, Fields TA, McCall SJ, Yu MJ, Kourany WM, Frey CW, Le TH. | 01/21/2010 |
| Tmem27 is a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets | Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.
Akpinar P, Kuwajima S, Krützfeldt J, Stoffel M. | 01/21/2010 |