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    PTGDS prostaglandin D2 synthase [ Homo sapiens (human) ]

    Gene ID: 5730, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Leveraging cell death patterns to predict metastasis in prostate adenocarcinoma and targeting PTGDS for tumor suppression.

    Leveraging cell death patterns to predict metastasis in prostate adenocarcinoma and targeting PTGDS for tumor suppression.
    Chen B, Guo L, Wang L, Wu P, Zheng X, Tan C, Xie N, Sun X, Zhou M, Huang H, Hao N, Lei Y, Yan K, Wu D, Du Y., Free PMC Article

    11/13/2024
    PGD2/PTGDR2 Signal Affects the Viability, Invasion, Apoptosis, and Stemness of Gastric Cancer Stem Cells and Prevents the Progression of Gastric Cancer.

    PGD2/PTGDR2 Signal Affects the Viability, Invasion, Apoptosis, and Stemness of Gastric Cancer Stem Cells and Prevents the Progression of Gastric Cancer.
    Zhang Q, Wang F, Huang Y, Gao P, Wang N, Tian H, Chen A, Li Y, Wang F.

    06/6/2024
    Thermodynamic stability of human lipocalin-type prostaglandin D synthase under various pH conditions.

    Thermodynamic stability of human lipocalin-type prostaglandin D synthase under various pH conditions.
    Iida T, Nakatsuji M, Teraoka Y, Goto Y, Yamamura T, Inui T.

    07/7/2023
    Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.

    Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.
    Shen BQ, Sankaranarayanan I, Price TJ, Tavares-Ferreira D., Free PMC Article

    04/1/2023
    Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-beta-catenin-STAT3 signaling.

    Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling.
    Hu S, Ren S, Cai Y, Liu J, Han Y, Zhao Y, Yang J, Zhou X, Wang X., Free PMC Article

    04/30/2022
    SNX10 and PTGDS are associated with the progression and prognosis of cervical squamous cell carcinoma.

    SNX10 and PTGDS are associated with the progression and prognosis of cervical squamous cell carcinoma.
    Jiang P, Cao Y, Gao F, Sun W, Liu J, Ma Z, Xie M, Fu S., Free PMC Article

    11/6/2021
    COX and PTGDS Gene Expression Levels in PGD2 Synthesis Pathway are Correlated with miR-520 in Patients with Vessel Restenosis.

    COX and PTGDS Gene Expression Levels in PGD2 Synthesis Pathway are Correlated with miR-520 in Patients with Vessel Restenosis.
    Rezaee S, Kakavandi N, Shabani M, Khosravi M, Hosseini-Fard SR, Najafi M.

    09/4/2021
    GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D2 in a Rab4-dependent mechanism.

    GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D(2) in a Rab4-dependent mechanism.
    Fréchette L, Binda C, Génier S, Degrandmaison J, Boisvert M, Parent JL.

    08/7/2021
    Lipocalin-type prostaglandin D synthase levels increase in patients with narcolepsy and idiopathic hypersomnia.

    Lipocalin-type prostaglandin D synthase levels increase in patients with narcolepsy and idiopathic hypersomnia.
    Wang P, Li Q, Dong X, An H, Li J, Zhao L, Yan H, Aritake K, Huang Z, Strohl KP, Urade Y, Zhang J, Han F.

    05/1/2021
    Evidence for shrunken pore syndrome in children.

    Evidence for shrunken pore syndrome in children.
    den Bakker E, Gemke RJ, van Wijk JA, Hubeek I, Stoffel-Wagner B, Bökenkamp A.

    03/13/2021
    YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2.

    YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2.
    Bie Q, Li X, Liu S, Yang X, Qian Z, Zhao R, Zhang X, Zhang B.

    01/16/2021
    Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-beta fibrils.

    Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils.
    Kannaian B, Sharma B, Phillips M, Chowdhury A, Manimekalai MSS, Adav SS, Ng JTY, Kumar A, Lim S, Mu Y, Sze SK, Grüber G, Pervushin K., Free PMC Article

    10/31/2020
    Galectin-3 and beta-trace protein concentrations are higher in clinically unaffected patients with Fabry disease.

    Galectin-3 and β-trace protein concentrations are higher in clinically unaffected patients with Fabry disease.
    Hernández-Romero D, Sánchez-Quiñones J, Vílchez JA, Rivera-Caravaca JM, de la Morena G, Lip GYH, Climent V, Marín F., Free PMC Article

    10/24/2020
    -type prostaglandin D synthase regulates the trafficking of the PGD2 DP1 receptor by interacting with the GTPase Rab4

    L-type prostaglandin D synthase regulates the trafficking of the PGD(2) DP1 receptor by interacting with the GTPase Rab4.
    Binda C, Génier S, Degrandmaison J, Picard S, Fréchette L, Jean S, Marsault E, Parent JL., Free PMC Article

    06/13/2020
    that in the HCl-induced murine ALI model PGD2 was produced locally by inflamed endothelial and epithelial L-PGDS and this enhanced the endothelial barrier through the DP receptor

    L-PGDS-derived PGD(2) attenuates acute lung injury by enhancing endothelial barrier formation.
    Horikami D, Toya N, Kobayashi K, Omori K, Nagata N, Murata T.

    04/11/2020
    Herein, we found that PTGDS is overexpressed in AGA.

    Prostaglandins in androgenetic alopecia in 12 men and four female.
    Villarreal-Villarreal CD, Sinclair RD, Martínez-Jacobo L, Garza-Rodríguez V, Rodríguez-León SA, Lamadrid-Zertuche AC, Rodríguez-Gutierrez R, Ortiz-Lopez R, Rojas-Martinez A, Ocampo-Candiani J.

    01/18/2020
    The expression levels of CDC20 and PTGDS were able to predict overall survival in diffuse large B-cell lymphoma patients.

    Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma.
    Sun C, Cheng X, Wang C, Wang X, Xia B, Zhang Y., Free PMC Article

    07/27/2019
    Prostaglandin D2 synthase 21 kDa (brain) (PTGDS) was found to be expressed at a significantly higher level in the tumors of highgrade serous ovarian cancer (HGSOC) patients with a short diseasefree survival time. Inverse profile, with positivity for PTGDS product prostaglandin D2 strongly associated with an increase in diseasefree survival, the absence of relapse and sensitivity to platinumbased therapy.

    Prostaglandin D2 expression is prognostic in high‑grade serous ovarian cancer.
    Alves MR, Do Amaral NS, Marchi FA, Silva FIB, Da Costa AABA, Carvalho KC, Baiocchi G, Soares FA, De Brot L, Rocha RM.

    07/6/2019
    The DHEA metabolite 7beta-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines.

    The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines.
    Sandra N, Ester P, Marie-Agnès P, Robert M, Olivier H.

    04/23/2019
    Lipocalin-type PGD synthase is a novel phytocannabinoid-binding protein.

    Lipocalin-Type Prostaglandin D Synthase Is a Novel Phytocannabinoid-Binding Protein.
    Elmes MW, Volpe AD, d'Oelsnitz S, Sweeney JM, Kaczocha M., Free PMC Article

    04/13/2019
    High lipocalin-type prostaglandin D synthase expression is associated with Spontaneous intracranial hypotension.

    Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid.
    Murakami Y, Takahashi K, Hoshi K, Ito H, Kanno M, Saito K, Nollet K, Yamaguchi Y, Miyajima M, Arai H, Hashimoto Y, Mima T.

    11/10/2018
    Measurement of serum BTP can be a reliable tool for detecting kidney function in neonates.

    Serum Beta-Trace Protein for Assessment of Kidney Function in Neonates.
    Khosravi N, Asgari M, Khalessi N, Hoseini R, Khosravi N.

    09/22/2018
    Thus, our results suggest decreased NK cell-mediated eosinophil regulation, possibly through an increased level of PGD2, as a previously unrecognized link between PG dysregulation and eosinophilic inflammation in CRS.

    Natural killer cells regulate eosinophilic inflammation in chronic rhinosinusitis.
    Kim JH, Choi GE, Lee BJ, Kwon SW, Lee SH, Kim HS, Jang YJ., Free PMC Article

    04/28/2018
    These observations suggest that tumor cell-derived inflammatory cytokines increase L-PGDS expression and subsequent PGD2 production in the tumor endothelial cells (ECs). This PGD2 acts as a negative regulator of the tumorigenic changes in tumor ECs.

    Lipocalin-type prostaglandin D synthase-derived PGD(2) attenuates malignant properties of tumor endothelial cells.
    Omori K, Morikawa T, Kunita A, Nakamura T, Aritake K, Urade Y, Fukayama M, Murata T.

    01/13/2018
    The cut off value for betaTP in the diagnosis and follow-up of cerebrospinal fluid leaks should be modified depending on the type of secretion (sample type), for a better diagnostic accuracy

    Sample-dependent diagnostic accuracy of prostaglandin D synthase in cerebrospinal fluid leak.
    Morell-Garcia D, Bauça JM, Sastre MP, Yañez A, Llompart I.

    02/18/2017
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