| CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma. | CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma.
Kakumani PK, Guitart T, Houle F, Harvey LM, Goyer B, Germain L, Gebauer F, Simard MJ. | 07/26/2024 |
| METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway. | METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
Yu H, Zhuang J, Zhou Z, Song Q, Lv J, Yang X, Yang H, Lu Q., Free PMC Article | 02/26/2024 |
| Exploring the role of PMEPA1 in gastric cancer. | Exploring the role of PMEPA1 in gastric cancer.
Wen F, Yang S, Cai W, Zhao M, Qin L, Jiao Z. | 12/15/2023 |
| PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer. | PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer.
Li J, Kong WM., Free PMC Article | 05/7/2022 |
| PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway. | PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway.
Tan B, Chen Y, Xia L, Yu X, Peng Y, Zhang X, Yang Z. | 12/25/2021 |
| PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer. | PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer.
Qiu D, Hu J, Hu J, Yu A, Othmane B, He T, Ding J, Cheng X, Ren W, Tan X, Yu Q, Chen J, Zu X., Free PMC Article | 12/25/2021 |
| PMEPA1 Stimulates the Proliferation, Colony Formation of Pancreatic Cancer Cells via the MAPK Signaling Pathway. | PMEPA1 Stimulates the Proliferation, Colony Formation of Pancreatic Cancer Cells via the MAPK Signaling Pathway.
Song M, Zhou B, Li B, Tian L. | 10/23/2021 |
| PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer. | PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer.
Sharad S, Dobi A, Srivastava S, Srinivasan A, Li H., Free PMC Article | 09/11/2021 |
| Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression. | Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression.
Zhang Y, Zhu H, Sun N, Zhang X, Liang G, Zhu J, Xia L, Kou Y, Lu J., Free PMC Article | 08/7/2021 |
| Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer. | Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer.
Wang B, Zhong JL, Li HZ, Wu B, Sun DF, Jiang N, Shang J, Chen YF, Xu XH, Lu HD. | 06/26/2021 |
| PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1. | PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1.
Ji J, Ding K, Luo T, Xu R, Zhang X, Huang B, Chen A, Zhang D, Miletic H, Bjerkvig R, Thorsen F, Wang J, Li X., Free PMC Article | 11/28/2020 |
| PMEPA1/TMEPAI isoforms function via its PY and Smad-interaction motifs for tumorigenic activities of breast cancer cells. | PMEPA1/TMEPAI isoforms function via its PY and Smad-interaction motifs for tumorigenic activities of breast cancer cells.
Puteri MU, Watanabe Y, Wardhani BWK, Amalia R, Abdelaziz M, Kato M. | 10/24/2020 |
| These data suggest that TMEPAI suppresses Wnt signaling by interfering with beta-catenin stability and nuclear translocation in a TGF-beta signaling-independent manner. | TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells.
Amalia R, Abdelaziz M, Puteri MU, Hwang J, Anwar F, Watanabe Y, Kato M. | 08/13/2020 |
| Prostate transmembrane protein androgen induced 1 (PMEPA1) promotes colorectal cancer metastasis and epithelial-to-mesenchymal transition (EMT) in vivo and in vitro. | PMEPA1 induces EMT via a non-canonical TGF-β signalling in colorectal cancer.
Zhang L, Wang X, Lai C, Zhang H, Lai M., Free PMC Article | 07/25/2020 |
| observed that knockout (KO) of PMEPA1 in human breast cancer cell line MDA-MB-231 using a CRISPR-Cas9 system resulted in reduction of in vivo tumour growth and lung metastasis but not of in vitro monolayer growth capacity of these KO cell lines | PMEPA1/TMEPAI knockout impairs tumour growth and lung metastasis in MDA-MB-231 cells without changing monolayer culture cell growth.
Abdelaziz M, Watanabe Y, Kato M. | 06/1/2019 |
| This study highlights that TMEPAI decreases c-Maf stability by recruiting the ubiquitin ligase NEDD4 to c-Maf for proteasomal degradation in myeloma cells. | The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor.
Du Y, Liu Y, Xu Y, Juan J, Zhang Z, Xu Z, Cao B, Wang Q, Zeng Y, Mao X., Free PMC Article | 01/12/2019 |
| JHY-A007-50 mediates the downregulation of TMEPAI expression. | 2-(2-nitrobenzylidene) indolin-3-one compound inhibits transmembrane prostate androgen-induced protein (TMEPAI) expression and cancer cell proliferation.
Li Y, Wang J, Song N, Zeng F, Zhao M, Wang A, Chen Y, Jing L, Yu P, Diao A., Free PMC Article | 10/6/2018 |
| describe recent progresses in the understanding of how the TMEPAI family physiologically contributes to cellular functions and diseases | TMEPAI family: involvement in regulation of multiple signalling pathways.
Itoh S, Itoh F. | 10/6/2018 |
| binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. | Kdm6b and Pmepa1 as Targets of Bioelectrically and Behaviorally Induced Activin A Signaling.
Link AS, Kurinna S, Havlicek S, Lehnert S, Reichel M, Kornhuber J, Winner B, Huth T, Zheng F, Werner S, Alzheimer C. | 01/20/2018 |
| study showed that the inhibition of autophagy induced by the depletion of TMEPAI is involved in regulation of Beclin-1. | TMEPAI increases lysosome stability and promotes autophagy.
Luo S, Yang M, Lv D, Jing L, Li Y, Liu Z, Diao A. | 09/9/2017 |
| these findings indicated that PMEPA1 participates in TGF-beta- and hypoxia-regulated gene expression networks in solid tumors and thereby may contribute to tumor progression. | PMEPA1, a TGF-β- and hypoxia-inducible gene that participates in hypoxic gene expression networks in solid tumors.
Koido M, Sakurai J, Tsukahara S, Tani Y, Tomida A. | 05/27/2017 |
| the present study suggest that the upregulation of miR19a3p expression levels contributes to tumor progression and that one of its underlying mechanisms involves inhibition of PMEPA1 expression. | miR‑19a‑3p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion.
Feng S, Zhu X, Fan B, Xie D, Li T, Zhang X. | 02/18/2017 |
| Sp1 up-regulated TMEPAI protein expression, as well as Sp1 promoting TMEPAI-induced cell proliferation. | Sp1 transcription factor promotes TMEPAI gene expression and contributes to cell proliferation.
Li Y, Guo A, Feng Y, Zhang Y, Wang J, Jing L, Yan Y, Jing L, Liu Z, Ma L, Diao A., Free PMC Article | 01/28/2017 |
| PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations. | Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression.
Nie Z, Wang C, Zhou Z, Chen C, Liu R, Wang D. | 11/5/2016 |
| these data elaborated on the diverse activity among TCF/LEF family members with respect to the transcriptional regulation of the TMEPAI gene. | Regulation of the TMEPAI promoter by TCF7L2: the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene.
Nakano N, Kato M, Itoh S., Free PMC Article | 10/1/2016 |