| O-GlcNAcylation determines the function of the key O-GalNAc glycosyltransferase C1GalT1 in bladder cancer. | O-GlcNAcylation determines the function of the key O-GalNAc glycosyltransferase C1GalT1 in bladder cancer.
Jiang Y, Wu J, Guan F, Liang L, Wang Y., Free PMC Article | 09/13/2024 |
| Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression. | Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression.
Watanabe K, Tasaka K, Ogata H, Kato S, Ueno H, Umeda K, Isobe T, Kubota Y, Sekiguchi M, Kimura S, Sato-Otsubo A, Hiwatari M, Ushiku T, Kato M, Oka A, Miyano S, Ogawa S, Takita J., Free PMC Article | 08/19/2024 |
| High core 1beta1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma. | High core 1β1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma.
Chen Y, Ji Y, Shen L, Li Y, Ren Y, Shi H, Li Y, Wu Y., Free PMC Article | 05/2/2024 |
| Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer. | Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer.
Lin NY, Lee JJ, Chen ST, Lin JA, Lin CH, Lin HY, Su YH, Chen CC, Lin MC, Kuo CY, Huang MC., Free PMC Article | 07/7/2023 |
| Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer. | Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer.
Tan Z, Jiang Y, Liang L, Wu J, Cao L, Zhou X, Song Z, Ye Z, Zhao Z, Feng H, Dong Z, Lin S, Zhou Z, Wang Y, Li X, Guan F., Free PMC Article | 07/30/2022 |
| Interaction between G ALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy. | Interaction between GALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy.
Wang YN, Zhou XJ, Chen P, Yu GZ, Zhang X, Hou P, Liu LJ, Shi SF, Lv JC, Zhang H., Free PMC Article | 09/25/2021 |
| Elevated miR-124-3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T-synthase. | Elevated miR-124-3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T-synthase.
Huang L, Sun TY, Hu LJ, Hu SL, Sun HM, Zhao FQ, Wu B, Yang S, Ji FQ, Zhou DS., Free PMC Article | 08/28/2021 |
| C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin alphav. | C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin α(v).
Kuo TC, Wu MH, Yang SH, Chen ST, Hsu TW, Jhuang JY, Liao YY, Tien YW, Huang MC., Free PMC Article | 07/31/2021 |
| Association analysis of DNA methyltransferases in IgA nephropathy. | Association analysis of DNA methyltransferases in IgA nephropathy.
Xia M, Chen G, Liu D, Tang X, Liu Y, Wu L, Liu Y, Liu H. | 01/9/2021 |
| C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. | C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer.
Lee PC, Chen ST, Kuo TC, Lin TC, Lin MC, Huang J, Hung JS, Hsu CL, Juan HF, Lee PH, Huang MC., Free PMC Article | 12/12/2020 |
| GM130 expression was significantly decreased in tonsil tissues and peripheral blood mononuclear cells of IgA nephropathy (IgAN) patients. Downregulation of GM130 can increase IgA1 O-glycosylation deficiency, which is thought to reduce C1GALT1 expression but not affect the expression of ST6GalNAC2. GM130 plays an important role in IgA1 O-glycans deficiency in IgAN patients, by negatively regulating C1GALT1 expression. | Loss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy.
Wang C, Ye M, Zhao Q, Xia M, Liu D, He L, Chen G, Peng Y, Liu H. | 05/30/2020 |
| C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer. | C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer.
Lin MC, Chien PH, Wu HY, Chen ST, Juan HF, Lou PJ, Huang MC., Free PMC Article | 07/6/2019 |
| findings indicate that T-synthase deficiency in colorectal cancer cells not only is responsible for aberrant O-glycosylation, but also triggers the molecular process of EMT pathway, which may translate to increased invasiveness and metastasis in cancers | T-Synthase Deficiency Enhances Oncogenic Features in Human Colorectal Cancer Cells via Activation of Epithelial-Mesenchymal Transition.
Dong X, Jiang Y, Liu J, Liu Z, Gao T, An G, Wen T., Free PMC Article | 01/19/2019 |
| In addition, we found that Tn-expressing colorectal cancers (CRC) cell lines had either loss-of-function mutations in Cosmc or reversible Tn antigen expression, which was not caused by the deficiency of T-synthase activity | Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers.
Sun X, Ju T, Cummings RD., Free PMC Article | 11/3/2018 |
| There was no relationship between rs1047763 and rs1008898 C1GALT1 polymorphisms and susceptibility to IgA nephropathy. (Meta-analysis) | The Association of rs1047763 and rs1008898 of C1GALT1 with IgA Nephropathy Risk: A Global Meta-Analysis.
Nie R, Cheng G, Zhang J, Dong Y, Wang C, Liu J, Qin X. | 03/31/2018 |
| C1GALT1 modifies O-glycan expression and enhances malignant behaviors in ovarian cancer cells, suggesting that C1GALT1 plays a role in the pathogenesis of ovarian cancer. | C1GALT1 Seems to Promote In Vitro Disease Progression in Ovarian Cancer.
Chou CH, Huang MJ, Liao YY, Chen CH, Huang MC. | 02/3/2018 |
| These findings demonstrate that common variation at C1GALT1 influences Gd-IgA1 level in the population, which independently associates with risk of progressive IgA nephropathy, and that the pathogenic importance of changes in IgA1 O-glycosylation may vary between white and Chinese patients with IgA nephropathy | Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1.
Gale DP, Molyneux K, Wimbury D, Higgins P, Levine AP, Caplin B, Ferlin A, Yin P, Nelson CP, Stanescu H, Samani NJ, Kleta R, Yu X, Barratt J., Free PMC Article | 09/2/2017 |
| Polymorphisms near C1galt1 (rs10486157) and its molecular chaperone, Cosmc (rs4825729), were associated with altered composition of the colonic mucosal microbiota in Crohn's disease patients. | Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.
Jacobs JP, Lin L, Goudarzi M, Ruegger P, McGovern DP, Fornace AJ Jr, Borneman J, Xia L, Braun J., Free PMC Article | 09/2/2017 |
| Data indicate that mRNA levels of both core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1GALT1) and C1GALT1-specific chaperone 1 protein (C1GALT1C1) determine the rate of secretion of galactose-deficient IgA1 (Gd-IgA1) in IgA1-producing cells. | GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.
Kiryluk K, Li Y, Moldoveanu Z, Suzuki H, Reily C, Hou P, Xie J, Mladkova N, Prakash S, Fischman C, Shapiro S, LeDesma RA, Bradbury D, Ionita-Laza I, Eitner F, Rauen T, Maillard N, Berthoux F, Floege J, Chen N, Zhang H, Scolari F, Wyatt RJ, Julian BA, Gharavi AG, Novak J., Free PMC Article | 06/10/2017 |
| The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1. TGFbeta1 stimulation significantly decreased the mRNA levels of C1GalT1 and Cosmc. TGFbeta1 may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 and Cosmc. | TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc.
Xiao J, Wang M, Xiong D, Wang Y, Li Q, Zhou J, Chen Q. | 05/20/2017 |
| There was no statistically significant difference between the two groups (P > 0.05). The rs1047763 SNP of the C1GALT1 gene probably has no correlation with genetic susceptibility to IgAN in Xinjiang Uyghur people. | Relationship between rs1047763 polymorphism of the C1GALT1 gene and susceptibility to immunoglobulin A nephropathy in Xinjiang Uyghur people.
Xue JN, Guo Y, Song X, Xue F, Yang SF, Jiang H, Bu-La RZ, Lu C. | 12/24/2016 |
| Polymorphisms in the C1GALT1 gene were associated with genetic susceptibility to Uyghur Immunoglobulin A (IgA) nephropathy. | Association between C1GALT1 variants and genetic susceptibility to IgA nephropathy in Uygur.
Li WL, Lu C. | 04/16/2016 |
| Overexpression of C1GALT1 enhanced breast cancer cell growth, migration, and invasion in vitro as well as tumor growth in vivo. | Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway.
Chou CH, Huang MJ, Chen CH, Shyu MK, Huang J, Hung JS, Huang CS, Huang MC., Free PMC Article | 03/5/2016 |
| C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity. | C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin β1 glycosylation and activity.
Liu CH, Hu RH, Huang MJ, Lai IR, Chen CH, Lai HS, Wu YM, Huang MC., Free PMC Article | 11/14/2015 |
| Cosmc and T-synthase are transcriptionally regulated at a basal level by the specificity protein/Kruppel-like transcription factor family of members. | Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation.
Zeng J, Mi R, Wang Y, Li Y, Lin L, Yao B, Song L, van Die I, Chapman AB, Cummings RD, Jin P, Ju T., Free PMC Article | 10/24/2015 |