| Pancancer analysis of NDUFA4L2 with focused role in tumor progression and metastasis of colon adenocarcinoma. | Pancancer analysis of NDUFA4L2 with focused role in tumor progression and metastasis of colon adenocarcinoma.
Zhou R, Sun Z, Zhou R, Wang M, Zhuo Q, Deng X, Wang Z, Xu Y. | 10/16/2024 |
| Transcriptional regulation of NDUFA4L2 by NFIB induces sorafenib resistance by decreasing reactive oxygen species in hepatocellular carcinoma. | Transcriptional regulation of NDUFA4L2 by NFIB induces sorafenib resistance by decreasing reactive oxygen species in hepatocellular carcinoma.
Zhou L, Mao LH, Li X, Wang QL, Chen SY, Chen ZJ, Lei J, Liu HT, Liao SQ, Ran T, Li XQ, Zhou ZH, He S., Free PMC Article | 03/13/2023 |
| Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia. | Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia.
Mesa-Ciller C, Turiel G, Guajardo-Grence A, Lopez-Rodriguez AB, Egea J, De Bock K, Aragonés J, Urrutia AA., Free PMC Article | 03/5/2023 |
| NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma. | NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.
Kubala JM, Laursen KB, Schreiner R, Williams RM, van der Mijn JC, Crowley MJ, Mongan NP, Nanus DM, Heller DA, Gudas LJ., Free PMC Article | 02/4/2023 |
| NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib. | NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib.
Chen Z, Wei X, Wang X, Zheng X, Chang B, Shen L, Zhu H, Yang M, Li S, Zheng X., Free PMC Article | 10/16/2021 |
| NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension. | NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension.
Liu Y, Nie X, Zhu J, Wang T, Li Y, Wang Q, Sun Z., Free PMC Article | 09/18/2021 |
| Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer. | Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer.
Wang H, Chong T, Li BY, Chen XS, Zhen WB., Free PMC Article | 01/16/2021 |
| Study showed that mitochondrial NDUFA4L2 was overexpressed in non-small cell lung cancer (NSCLC) tumor tissues. NDUFA4L2 was also overexpressed in NSCLC cell lines cultured in hypoxic conditions. Its expression is regulated by HIF1A. | Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress.
Meng L, Yang X, Xie X, Wang M., Free PMC Article | 03/28/2020 |
| This study identified NDUFA4L2 as the most highly expressed gene in renal cancer cells and evaluated its role in sustaining angiogenesis, chemoresistance, and mitochondrial dysfunction. | Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma.
Lucarelli G, Rutigliano M, Sallustio F, Ribatti D, Giglio A, Lepore Signorile M, Grossi V, Sanese P, Napoli A, Maiorano E, Bianchi C, Perego RA, Ferro M, Ranieri E, Serino G, Bell LN, Ditonno P, Simone C, Battaglia M., Free PMC Article | 12/21/2019 |
| hypoxia promotes the viability of cardiac stem cells in serum-free medium by HIF-1alpha/NDUFA4L2 signaling pathway. | Induction of the mitochondrial NDUFA4L2 protein by HIF-1a regulates heart regeneration by promoting the survival of cardiac stem cell.
Zheng J, Zhang M, Weng H. | 01/19/2019 |
| This study has provided the first clinical relevance of NDUFA4L2 in human cancer, and since NDUFA4L2 was HIF1-regulated in Hepatocellular carcinoma cells, suggested that Hepatocellular carcinoma patients with NDUFA4L2 overexpression may be suitable candidates for HIF inhibitor treatment. | NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma.
Lai RK, Xu IM, Chiu DK, Tse AP, Wei LL, Law CT, Lee D, Wong CM, Wong MP, Ng IO, Wong CC. | 02/3/2018 |
| NDUFA4L2 knockdown has a profound antiproliferative effect, alters metabolic pathways, and causes major stress in cultured clear cell renal cell carcinoma cells. | Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma.
Minton DR, Fu L, Mongan NP, Shevchuk MM, Nanus DM, Gudas LJ., Free PMC Article | 01/27/2018 |
| NDUFA4L2 expression levels were correlated with some clinical features of clear cell renal cell carcinoma (ccRCC). Multivariate analysis showed NDUFA4L2 expression was an independent prognostic factor for ccRCC patients. | NDUFA4L2 expression predicts poor prognosis in clear cell renal cell carcinoma patients.
Liu L, Lan G, Peng L, Xie X, Peng F, Yu S, Wang Y, Tang X. | 04/15/2017 |