| ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms. | ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
Steingruber L, Krabichler F, Franzmeier S, Wu W, Schlegel J, Koch M. | 12/6/2023 |
| ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension. | ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.
Li D, Shao NY, Moonen JR, Zhao Z, Shi M, Otsuki S, Wang L, Nguyen T, Yan E, Marciano DP, Contrepois K, Li CG, Wu JC, Snyder MP, Rabinovitch M., Free PMC Article | 12/25/2021 |
| microRNA-483 Protects Pancreatic beta-Cells by Targeting ALDH1A3. | microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3.
Wang Z, Mohan R, Chen X, Matson K, Waugh J, Mao Y, Zhang S, Li W, Tang X, Satin LS, Tang X., Free PMC Article | 10/23/2021 |
| Study using human SH-SY5Y neuroblastoma and 293T cells and transgenic mouse model show that CHD7 directly regulates expression of retinoic acid synthetic enzyme ALDH1A3. Results indicate that ALDH1A3 acts with CHD7 in a common genetic pathway to regulate inner ear development, providing insights for exploration of the pathogenic mechanisms underlying CHARGE syndrome. | CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development.
Yao H, Hill SF, Skidmore JM, Sperry ED, Swiderski DL, Sanchez GJ, Bartels CF, Raphael Y, Scacheri PC, Iwase S, Martin DM., Free PMC Article | 12/7/2019 |
| Study in diabetic mice reports the discovery of ALDH1A3 isoform as a biomarker of dysfunctional beta cells. | Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.
Kim-Muller JY, Fan J, Kim YJ, Lee SA, Ishida E, Blaner WS, Accili D., Free PMC Article | 09/15/2018 |
| This study identifies Sam68 as a key regulator of neural progenitor cell self-renewal and establishes a novel link between modulation of ALDH1A3 expression and maintenance of high glycolytic metabolism in the developing cortex. | Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing.
La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C., Free PMC Article | 11/4/2017 |
| Chromatin immunoprecipitation assay using RarB as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 and Foxn1 in mice. | Whole-Exome Sequencing in a South American Cohort Links ALDH1A3, FOXN1 and Retinoic Acid Regulation Pathways to Autism Spectrum Disorders.
Moreno-Ramos OA, Olivares AM, Haider NB, de Autismo LC, Lattig MC., Free PMC Article | 05/28/2016 |
| Data suggest that expression of Aldh1a3/Raldh3 in placenta plays role in differentiation/placentation of glycogen trophoblast cells (junctional zone cells) via production of a local source of retinoic acid. | Expression of aldehyde dehydrogenase family 1, member A3 in glycogen trophoblast cells of the murine placenta.
Outhwaite JE, Natale BV, Natale DR, Simmons DG. | 11/21/2015 |
| Raldh1 and Raldh3 influence enteric nervous system structure and function and heterozygosity for Raldh2 causes ENS defects | Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.
Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO., Free PMC Article | 11/2/2013 |
| ALDH1A3 and ALDH2 expression was detectable in ALDH(very-br) and ALDH(br) cells, unlike ALDH(dim) cells, albeit at lower levels compared with ALDH1A1 and ALDH1A2. | Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity.
Roehrich ME, Spicher A, Milano G, Vassalli G., Free PMC Article | 09/7/2013 |
| regulation of fat depots through the concerted action of Aldh1 enzymes establishes retinoic acid-dependent tandem regulation of transcription factors ZFP423 and PPARgamma in a depot-specific manner | Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.
Reichert B, Yasmeen R, Jeyakumar SM, Yang F, Thomou T, Alder H, Duester G, Maiseyeu A, Mihai G, Harrison EH, Rajagopalan S, Kirkland JL, Ziouzenkova O., Free PMC Article | 10/1/2011 |
| Kinetic characterization of RALDH3 and 4, providing their specificities for retinal isomer substrates. | Kinetic characterization of recombinant mouse retinal dehydrogenase types 3 and 4 for retinal substrates.
Sima A, Parisotto M, Mader S, Bhat PV. | 03/8/2010 |
| Raldh2 and Raldh3 are selectively expressed in cortical stroma and in the ureteric bud during kidney development. | Non-cell-autonomous retinoid signaling is crucial for renal development.
Rosselot C, Spraggon L, Chia I, Batourina E, Riccio P, Lu B, Niederreither K, Dolle P, Duester G, Chambon P, Costantini F, Gilbert T, Molotkov A, Mendelsohn C., Free PMC Article | 01/21/2010 |
| Three retinaldehyde dehydrogenases (RALDH1, RALDH2 and RALDH3), show differential expression patterns throughout later mouse organogenesis | Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse.
Niederreither K, Fraulob V, Garnier JM, Chambon P, Dollé P. | 01/21/2010 |
| RALDH3 (retinal dehydrogenase 3) was characterized by kinetic and binding studies, protein engineering, homology modelling, ligand docking and electrostatic-potential calculations. | Characterization of retinaldehyde dehydrogenase 3.
Graham CE, Brocklehurst K, Pickersgill RW, Warren MJ., Free PMC Article | 01/21/2010 |
| The expression patterns of aldh1a2 and aldh1a3 retinoic acid synthesizing enzymes at specific follicular sites suggest that they mediate and are regulated by different epithelial proliferation and differentiation signaling pathways. | Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation.
Everts HB, King LE Jr, Sundberg JP, Ong DE. | 01/21/2010 |
| Raldh3 knockout suppresses retinoic acid synthesis and causes malformations restricted to ocular and nasal regions | A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment.
Dupé V, Matt N, Garnier JM, Chambon P, Mark M, Ghyselinck NB., Free PMC Article | 01/21/2010 |
| the role of retinoic acid during forebrain development begins late when Raldh3 expression initiates in the ventral subventricular zone | Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zone.
Molotkova N, Molotkov A, Duester G., Free PMC Article | 01/21/2010 |
| RALDH3 is transiently expressed during early postnatal cortical development, suggesting an important role in cortical neuronal development. | Retinoic acid synthesis in the postnatal mouse brain marks distinct developmental stages and functional systems.
Wagner E, Luo T, Dräger UC. | 01/21/2010 |
| During the first postnatal week, the RALDH3-expressing territory translocates in the caudal cortex from the medial limbic lobe to the adjacent neocortex and requires the neurotrophin NT-3. | Retinoic acid delineates the topography of neuronal plasticity in postnatal cerebral cortex.
Wagner E, Luo T, Sakai Y, Parada LF, Dräger UC. | 01/21/2010 |
| RA-generating activities in Raldh2-null mouse embryos could be ascribed to RALDH3 in eye, nasal, and inner ear epithelia, and within the mesonephric area that expresses RALDH3. | Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo.
Niederreither K, Vermot J, Fraulob V, Chambon P, Dolle P., Free PMC Article | 01/21/2010 |