| Regulation of Hepatocytes in G0 and G1 Phases by NOTCH3 mRNA, miR-369-3p, and rno-Rmdn2_0006 during the Initial Stage of Rat Liver Regeneration. | Regulation of Hepatocytes in G0 and G1 Phases by NOTCH3 mRNA, miR-369-3p, and rno-Rmdn2_0006 during the Initial Stage of Rat Liver Regeneration.
Zang X, Wang Z, Li Y, Gao H, Guo J, Jin W, Chang C, Lin J, Zhu K, Xu C., Free PMC Article | 05/12/2023 |
| Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell Function and Alleviates Ischemic Stroke by Upregulating NOTCH3. | Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell Function and Alleviates Ischemic Stroke by Upregulating NOTCH3.
Zhu T, Chen H, He C, Liu X. | 04/9/2022 |
| Monocrotaline-induced pulmonary hypertension rats had high expressions of the Notch3-HES5 signal pathway in the pulmonary arterioles. | Exploration of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension using rat model.
Chen X, Zhou W, Hu Q, Huang L. | 01/4/2020 |
| Up-regulation of Notch3 signaling in pulmonary artery smooth muscle cells promotes the development of extrauterine growth restriction-induced pulmonary hypertension. | Notch3 signaling activation in smooth muscle cells promotes extrauterine growth restriction-induced pulmonary hypertension.
Wang Y, Dai S, Cheng X, Prado E, Yan L, Hu J, He Q, Lv Y, Lv Y, Du L. | 12/21/2019 |
| mild hypothermia inhibits Notch 3 and Notch 4 activation and seizure after stroke in the rat model | Mild hypothermia inhibits the Notch 3 and Notch 4 activation and seizure after stroke in the rat model.
Yang GS, Zhou XY, An XF, Liu XJ, Zhang YJ, Yu D. | 10/27/2018 |
| Cysteine-sparing NOTCH3 missense mutations are associated with typical clinical CADASIL syndrome and typical magnetic resonance imaging (MRI) findings, although with less involvement of the anterior temporal lobe. | Systematic Review of Cysteine-Sparing NOTCH3 Missense Mutations in Patients with Clinical Suspicion of CADASIL.
Muiño E, Gallego-Fabrega C, Cullell N, Carrera C, Torres N, Krupinski J, Roquer J, Montaner J, Fernández-Cadenas I., Free PMC Article | 06/2/2018 |
| Our data provide the first evidence for a critical sequential role for mTOR-Notch3-PDGF-beta receptor signaling in the pathogenesis of chronic neonatal pulmonary hypertension. | mTOR-Notch3 signaling mediates pulmonary hypertension in hypoxia-exposed neonatal rats independent of changes in autophagy.
Ivanovska J, Shah S, Wong MJ, Kantores C, Jain A, Post M, Yeganeh B, Jankov RP. | 04/21/2018 |
| We find that across species, the atypical receptor NOTCH3 is differentially overexpressed; it is progressively up-regulated with disease development and promotes tumor cell survival via activation of PI3k-Akt | Notch3 drives development and progression of cholangiocarcinoma.
Guest RV, Boulter L, Dwyer BJ, Kendall TJ, Man TY, Minnis-Lyons SE, Lu WY, Robson AJ, Gonzalez SF, Raven A, Wojtacha D, Morton JP, Komuta M, Roskams T, Wigmore SJ, Sansom OJ, Forbes SJ., Free PMC Article | 02/10/2018 |
| Notch3 signaling activation stimulated pulmonary vascular cells proliferation. | Inhibition of Notch3 prevents monocrotaline-induced pulmonary arterial hypertension.
Zhang Y, Xie X, Zhu Y, Liu L, Feng W, Pan Y, Zhai C, Ke R, Li S, Song Y, Fan Y, Fan F, Wang X, Li F, Li M. | 06/28/2016 |
| Notch3, Jagged1, Hes1 and alpha-SMA were downregulated. This downregulation was accompanied by improved hepatic fibrosis after the inhibition of Notch3 in vivo. | Recombinant adeno-associated virus-mediated transfer of shRNA against Notch3 ameliorates hepatic fibrosis in rats.
Zheng SP, Chen YX, Guo JL, Qi D, Zheng SJ, Zhang SL, Weng ZH. | 10/19/2013 |
| Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury. | Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury.
Djudjaj S, Chatziantoniou C, Raffetseder U, Guerrot D, Dussaule JC, Boor P, Kerroch M, Hanssen L, Brandt S, Dittrich A, Ostendorf T, Floege J, Zhu C, Lindenmeyer M, Cohen CD, Mertens PR. | 01/12/2013 |
| These findings imply that Notch3 may not only be a regulator of fetal liver stem/progenitor cells differentiation into hepatocytes, but also be a potential marker of fetal liver stem/progenitor cells. | Notch is the key factor in the process of fetal liver stem/progenitor cells differentiation into hepatocytes.
Wang T, You N, Tao K, Wang X, Zhao G, Xia N, Li N, Tang L, Liu W, Dou K. | 11/3/2012 |
| Jaggged1 can inhibit neointima formation after balloon injury by decreasing smooth muscle cell proliferation and migration through interference with Notch1/3-Herp2 signaling. | Soluble Jagged-1 inhibits neointima formation by attenuating Notch-Herp2 signaling.
Caolo V, Schulten HM, Zhuang ZW, Murakami M, Wagenaar A, Verbruggen S, Molin DG, Post MJ. | 06/25/2011 |
| Data demonstrate that extracellular YB-1 associates with outer cell membrane components and interacts with extracellular Notch-3 receptor domains. | YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation.
Rauen T, Raffetseder U, Frye BC, Djudjaj S, Mühlenberg PJ, Eitner F, Lendahl U, Bernhagen J, Dooley S, Mertens PR., Free PMC Article | 01/21/2010 |
| These results demonstrate that the Notch3 pathway is attenuated through IL-1beta and through NF-kappaB activation, allowing vascular smooth muscle cells to switch into an inflammatory state. | Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk.
Clément N, Gueguen M, Glorian M, Blaise R, Andréani M, Brou C, Bausero P, Limon I. | 01/21/2010 |
| Rgs5 and Notch3 are expressed in pericytes of developing and injured teeth and have roles along with vascular-derived stem cells during pulp healing | Coexpression of Notch3 and Rgs5 in the pericyte-vascular smooth muscle cell axis in response to pulp injury.
Lovschall H, Mitsiadis TA, Poulsen K, Jensen KH, Kjeldsen AL. | 01/21/2010 |
| Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation | Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis.
Wang W, Prince CZ, Mou Y, Pollman MJ. | 01/21/2010 |