| Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis. | Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis.
Steffan BN, Calise D, Park SC, Niu M, Yang J, Hammock BD, Jones M, Steele C, Keller NP., Free PMC Article | 07/13/2023 |
| Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia. | Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia.
Yi C, He J, Huang D, Zhao Y, Zhang C, Ye X, Huang Y, Nussinov R, Zheng J, Liu M, Lu W., Free PMC Article | 12/10/2022 |
| The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages. | The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages.
Vadevoo SMP, Gunassekaran GR, Lee C, Lee N, Lee J, Chae S, Park JY, Koo J, Lee B., Free PMC Article | 12/25/2021 |
| Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation. | Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
Li Q, Feng C, Li L, Xu G, Gu H, Li S, Li D, Liu M, Han S, Zheng B. | 09/18/2021 |
| The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain. | The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain.
Osthues T, Zimmer B, Rimola V, Klann K, Schilling K, Mathoor P, Angioni C, Weigert A, Geisslinger G, Münch C, Scholich K, Sisignano M., Free PMC Article | 03/6/2021 |
| this study shows that G2A protects mice againstsSepsis by modulating Kupffer cell activation via cooperativity with adenosine receptor 2b | G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b.
Li HM, Jang JH, Jung JS, Shin J, Park CO, Kim YJ, Ahn WG, Nam JS, Hong CW, Lee J, Jung YJ, Chen JF, Ravid K, Lee HT, Huh WK, Kabarowski JH, Song DK., Free PMC Article | 11/2/2019 |
| G2A is necessary to position macrophages in the proinflammatory microenvironment surrounding the center of inflammation. In absence of G2A the macrophages are localized in an antiinflammatory microenvironment and macrophage polarization is shifted toward M2-like macrophages. | The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.
Kern K, Schäfer SMG, Cohnen J, Pierre S, Osthues T, Tarighi N, Hohmann S, Ferreiros N, Brüne B, Weigert A, Geisslinger G, Sisignano M, Scholich K., Free PMC Article | 10/26/2019 |
| GPR132 responds to a select panel of oxygenated polyunsaturated fatty acids to enhance both embryonic and adult hematopoiesis. | Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.
Lahvic JL, Ammerman M, Li P, Blair MC, Stillman ER, Fast EM, Robertson AL, Christodoulou C, Perlin JR, Yang S, Chiang N, Norris PC, Daily ML, Redfield SE, Chan IT, Chatrizeh M, Chase ME, Weis O, Zhou Y, Serhan CN, Zon LI., Free PMC Article | 10/6/2018 |
| G2A overexpression reduced the infiltration of granulocytes and attenuated hyperalgesia after CFA injection. G2A knockdown increased the number of immune cells before CFA injection and prolonged the inflammatory hyperalgesia. | G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia.
Su YS, Huang YF, Wong J, Lee CW, Hsieh WS, Sun WH. | 08/18/2018 |
| Lactate activates macrophage Gpr132 to promote the alternatively activated macrophage (M2)-like phenotype, which, in turn, facilitates cancer cell adhesion, migration, and invasion. Consequently, Gpr132 deletion reduces M2 macrophages and impedes breast cancer lung metastasis in mice. | Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
Chen P, Zuo H, Xiong H, Kolar MJ, Chu Q, Saghatelian A, Siegwart DJ, Wan Y., Free PMC Article | 04/21/2018 |
| The authors report that macrophage PPARgamma deletion in mice not only exacerbates mammary tumor development but also impairs the anti-tumor effects of rosiglitazone. Mechanistically, the authors identify Gpr132 as a novel direct PPARgamma target in macrophage whose expression is enhanced by PPARgamma loss but repressed by PPARgamma activation. | Macrophage PPARγ inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone.
Cheng WY, Huynh H, Chen P, Peña-Llopis S, Wan Y., Free PMC Article | 11/11/2017 |
| the data suggest that G2A signaling serves to dampen intestinal inflammation via the production of IFN-gamma, which, in turn, enhances monocyte maturation to a less inflammatory program and ultimately reduces eosinophil-induced injury of colonic tissues | G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ.
Frasch SC, McNamee EN, Kominsky D, Jedlicka P, Jakubzick C, Zemski Berry K, Mack M, Furuta GT, Lee JJ, Henson PM, Colgan SP, Bratton DL., Free PMC Article | 08/5/2017 |
| Lyso-PS signaled to macrophages in a G2A-dependent manner for their enhanced production of prostaglandin E2 (PGE2) via a calcium-dependent cytosolic phospholipase A2/cyclooxygenase-mediated mechanism. | Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity.
Frasch SC, Fernandez-Boyanapalli RF, Berry KZ, Leslie CC, Bonventre JV, Murphy RC, Henson PM, Bratton DL., Free PMC Article | 07/23/2011 |
| study of the G2A-mediated effects in the pathophysiology of T cell-mediated autoimmune disease; it was concluded that the proposed anti-proliferative and chemotactic functions of G2A are not manifested in vivo | Deletion of the G2A receptor fails to attenuate experimental autoimmune encephalomyelitis.
Osmers I, Smith SS, Parks BW, Yu S, Srivastava R, Wohler JE, Barnum SR, Kabarowski JH., Free PMC Article | 01/21/2010 |
| ApoE-dependent modulation of HDL and atherosclerosis by G2A in LDL receptor-deficient mice independent of bone marrow-derived cells. | ApoE-dependent modulation of HDL and atherosclerosis by G2A in LDL receptor-deficient mice independent of bone marrow-derived cells.
Parks BW, Srivastava R, Yu S, Kabarowski JH., Free PMC Article | 01/21/2010 |
| In the absence of G2A, increased macrophage activation and decreased apoptosis is associated with accumulation of macrophages in the aorta and increased atherosclerosis | G2A deficiency in mice promotes macrophage activation and atherosclerosis.
Bolick DT, Skaflen MD, Johnson LE, Kwon SC, Howatt D, Daugherty A, Ravichandran KS, Hedrick CC., Free PMC Article | 01/21/2010 |
| NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A. | NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A.
Frasch SC, Berry KZ, Fernandez-Boyanapalli R, Jin HS, Leslie C, Henson PM, Murphy RC, Bratton DL., Free PMC Article | 01/21/2010 |
| The G2A receptor is important for hepatobiliary bile salt, cholesterol, and phospholipid homeostasis and for the pathogenesis of cholesterol gallstone formation. | The G protein-coupled receptor G2A: involvement in hepatic lipid metabolism and gallstone formation in mice.
Johnson LE, Elias MS, Bolick DT, Skaflen MD, Green RM, Hedrick CC., Free PMC Article | 01/21/2010 |
| G2A signaling regulates macrophage chemotaxis to lysophosp[hatidylcholine. | Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A.
Yang LV, Radu CG, Wang L, Riedinger M, Witte ON. | 01/21/2010 |
| G2A is expressed predominantly by macrophages within atherosclerotic lesions at the aortic root of apolipoprotein E-deficient mice. | Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.
Rikitake Y, Hirata K, Yamashita T, Iwai K, Kobayashi S, Itoh H, Ozaki M, Ejiri J, Shiomi M, Inoue N, Kawashima S, Yokoyama M. | 01/21/2010 |
| Examination of lipoprotein profiles revealed elevated levels of circulating high-density lipoprotein (HDL) cholesterol in G2A-/- LDLR-/- mice compared with their G2A+/+ LDLR-/- counterparts after extended periods of diet intervention. | Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice.
Parks BW, Lusis AJ, Kabarowski JH. | 01/21/2010 |
| role of G2A in lysophosphatidylcholine-mediated T-cell migration | T cell chemotaxis to lysophosphatidylcholine through the G2A receptor.
Radu CG, Yang LV, Riedinger M, Au M, Witte ON., Free PMC Article | 01/21/2010 |
| data indicate the ability of lysophosphatidylcholine to stimulate macrophage & T-cell chemotaxis via G2A is not manifested in vivo & G2A-mediated proapoptotic rather than chemotactic action is most penetrant during atherogenesis | Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice.
Parks BW, Gambill GP, Lusis AJ, Kabarowski JH. | 01/21/2010 |
| the neuritogenic effect of sPLA2 is mediated by generation of LPC and subsequent activation of G2A | Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.
Ikeno Y, Konno N, Cheon SH, Bolchi A, Ottonello S, Kitamoto K, Arioka M. | 01/21/2010 |
| Endothelial G2A expression may aid in prevention of vascular inflammation and atherosclerosis. | Absence of the G protein-coupled receptor G2A in mice promotes monocyte/endothelial interactions in aorta.
Bolick DT, Whetzel AM, Skaflen M, Deem TL, Lee J, Hedrick CC. | 01/21/2010 |