| Galectin-1 as a marker for microglia activation in the aging brain. | Galectin-1 as a marker for microglia activation in the aging brain.
Kiss T, Mir Y, Stefancsik G, Ganbat G, Askarova A, Monostori E, Dulka K, Szebeni GJ, Nyúl-Tóth Á, Csiszár A, Legradi A. | 10/4/2023 |
| Dysregulated Gal-1 and Ca(V)1.2 alternative exon 9* might be attributed to the pathological processes of cardiac hypertrophy, and provides a potential anti-hypertrophic target in the heart. | Galectin-1 attenuates cardiomyocyte hypertrophy through splice-variant specific modulation of Ca(V)1.2 calcium channel.
Fan J, Fan W, Lei J, Zhou Y, Xu H, Kapoor I, Zhu G, Wang J. | 08/17/2019 |
| Stress-induced Gal-1 immediately accumulates in the spleen and thymus, and may modulate the immune response through apoptosis by binding to CD45(+) lymphocytes in immune organs following physiological and/or psychological stress. | Stress-induced galectin-1 influences immune tolerance in the spleen and thymus by modulating CD45 immunoreactive lymphocytes.
Sasaguri K, Yamada K, Narimatsu Y, Oonuki M, Oishi A, Koda K, Kubo KY, Yamamoto T, Kadoya T., Free PMC Article | 03/24/2018 |
| GAL1 has an essential role in HFD-induced obesity development. From a clinical viewpoint, pharmaceutical targeting of GAL1 using TDG and other inhibitor compounds would be a novel therapeutic approach for the treatment of obesity | Targeted inhibition of galectin 1 by thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.
Mukherjee R, Kim SW, Park T, Choi MS, Yun JW. | 08/13/2016 |
| Galectin-1 protein is protective on in vivo and in vitro models of ocular inflammation. | Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation.
Zanon Cde F, Sonehara NM, Girol AP, Gil CD, Oliani SM., Free PMC Article | 06/28/2016 |
| Galectin-1-binding glycoforms of haptoglobin | Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients.
Carlsson MC, Cederfur C, Schaar V, Balog CI, Lepur A, Touret F, Salomonsson E, Deelder AM, Fernö M, Olsson H, Wuhrer M, Leffler H., Free PMC Article | 02/25/2012 |
| Gal-1 regulates I(Ca,L) by decreasing the surface expression of Ca(V)1.2 channels in a splice variant selective manner. This may modulate vasoconstriction. Gal-1 binds the I-II loop only in the absence of alternatively spliced exon 9*. | Splice variant specific modulation of CaV1.2 calcium channel by galectin-1 regulates arterial constriction.
Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW. | 01/7/2012 |
| These results demonstrate that myenteric denervation downregulates endogenous Gal-1 and -3 expression, which might inhibit tumor development in this experimental model. | Myenteric denervation downregulates galectin-1 and -3 expression in gastric carcinogenesis.
Estofolete CF, Zucoloto S, Oliani SM, Polli-Lopes AC, Gil CD. | 07/30/2011 |
| The interaction of native dimeric and monomeric mutants of rat and human galectin-1 with mono- and divalent small molecules, fetuin, asialofetuin, and human serum glycoproteins was analyzed. | Monovalent interactions of galectin-1.
Salomonsson E, Larumbe A, Tejler J, Tullberg E, Rydberg H, Sundin A, Khabut A, Frejd T, Lobsanov YD, Rini JM, Nilsson UJ, Leffler H. | 05/14/2011 |
| Endogenous galectin-1 was found to be markedly upregulated, paralleled with increased astrocytic BDNF production under ischemic conditions both in vitro and in vivo. | Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia.
Qu WS, Wang YH, Wang JP, Tang YX, Zhang Q, Tian DS, Yu ZY, Xie MJ, Wang W. | 02/5/2011 |
| Expression of galectin-1 was remarkably up-regulated in activated astrocytes around cerebral ischemic infarct. | Galectin-1 attenuates astrogliosis-associated injuries and improves recovery of rats following focal cerebral ischemia.
Qu WS, Wang YH, Ma JF, Tian DS, Zhang Q, Pan DJ, Yu ZY, Xie MJ, Wang JP, Wang W. | 01/22/2011 |
| Galectin-1 plays an important role in CD8+ T cell-mediated renal rejection by inducing immunological tolerance. | Immunological tolerance induced by galectin-1 in rat allogeneic renal transplantation.
Xu G, Tu W, Xu C. | 09/6/2010 |
| Galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome. | Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome.
Shimizu M, Khoshnoodi J, Akimoto Y, Kawakami H, Hirano H, Higashihara E, Hosoyamada M, Sekine Y, Kurayama R, Kurayama H, Joh K, Hirabayashi J, Kasai K, Tryggvason K, Ito N, Yan K. | 01/21/2010 |
| The results are compatible with a role for galectin-1 in facilitating reinnervation of denervated skeletal muscle. | Galectin-1 expression in innervated and denervated skeletal muscle.
Svensson A, Tågerud S., Free PMC Article | 01/21/2010 |
| In conclusion, our results suggest a role of galectin-1 in chemokine production and proliferation through its beta-galactoside binding activity in activated PSCs. | Galectin-1 induces chemokine production and proliferation in pancreatic stellate cells.
Masamune A, Satoh M, Hirabayashi J, Kasai K, Satoh K, Shimosegawa T. | 01/21/2010 |
| point to a balanced expression of cell-associated-Gal-1/Gal-3 and might impact on the development of new therapeutic strategies for inflammatory diseases | Inflammation-induced modulation of cellular galectin-1 and -3 expression in a model of rat peritonitis.
Gil CD, Cooper D, Rosignoli G, Perretti M, Oliani SM. | 01/21/2010 |
| These data suggest that endogenous galectin-1 may potentiate neuropathic pain after the peripheral nerve injury at least partly by increasing SPR in the dorsal horn. | Galectin-1 is involved in the potentiation of neuropathic pain in the dorsal horn.
Imbe H, Okamoto K, Kadoya T, Horie H, Senba E. | 01/21/2010 |
| Galectin-1 interacts with beta-1 subunit of integrin | Galectin-1 interacts with beta-1 subunit of integrin.
Moiseeva EP, Williams B, Goodall AH, Samani NJ. | 01/21/2010 |
| Expression in testis was developmentally regulated, and its immunolabeling exhibited a stage-specific pattern throughout the spermatogenic process. | Regulated expression and ultrastructural localization of galectin-1, a proapoptotic beta-galactoside-binding lectin, during spermatogenesis in rat testis.
Dettin L, Rubinstein N, Aoki A, Rabinovich GA, Maldonado CA. | 01/21/2010 |
| it appears that galectin-1 and galectin-3 could participate in beta-galactoside binding and induce different intracellular signaling pathways leading to the proliferation of hepatocyte stellate cells | Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways.
Maeda N, Kawada N, Seki S, Arakawa T, Ikeda K, Iwao H, Okuyama H, Hirabayashi J, Kasai K, Yoshizato K. | 01/21/2010 |
| the expression of galectin-1 in neurons correlates with the regenerative propensity. | Galectin-1 expression correlates with the regenerative potential of rubrospinal and spinal motoneurons.
McGraw J, Oschipok LW, Liu J, Hiebert GW, Mak CF, Horie H, Kadoya T, Steeves JD, Ramer MS, Tetzlaff W. | 01/21/2010 |
| Analysis of galectin-1 signalling in pancreatic stellate cells revealed an activation of the extracellular signal-regulated kinases 1 and 2 and enhanced DNA binding of AP-1 transcription factors. | Galectin-1 is an inductor of pancreatic stellate cell activation.
Fitzner B, Walzel H, Sparmann G, Emmrich J, Liebe S, Jaster R. | 01/21/2010 |
| Gal-1 promotes H-Ras signaling to Raf . | Spatiotemporal organization of Ras signaling: rasosomes and the galectin switch.
Ashery U, Yizhar O, Rotblat B, Elad-Sfadia G, Barkan B, Haklai R, Kloog Y. | 01/21/2010 |