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    Fgf21 fibroblast growth factor 21 [ Mus musculus (house mouse) ]

    Gene ID: 56636, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Fibroblast growth factor 21 alleviates acetaminophen induced acute liver injury by activating Sirt1 mediated autophagy.

    Fibroblast growth factor 21 alleviates acetaminophen induced acute liver injury by activating Sirt1 mediated autophagy.
    Xu G, Qiu F, Zhang W, Li S, Chen J, Wang G, Wang Y, Pan J, Pan X.

    11/6/2024
    BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21.

    BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21.
    Zheng H, Zhang X, Li C, Wang D, Shen Y, Lu J, Zhao L, Li X, Gao H., Free PMC Article

    08/30/2024
    Liver-Specific Nonviral Gene Delivery of Fibroblast Growth Factor 21 Protein Expression in Mice Regulates Body Mass and White/Brown Fat Respiration.

    Liver-Specific Nonviral Gene Delivery of Fibroblast Growth Factor 21 Protein Expression in Mice Regulates Body Mass and White/Brown Fat Respiration.
    Girer NG, Rontoyanni VG, Joshi A, Patrikeev I, Murton AJ, Porter C, Motamedi M, Elferink CJ., Free PMC Article

    08/27/2024
    Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy.

    Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy.
    Qi J, Wu Y, Guo Z, Zhu S, Xiong J, Hu F, Liang X, Ye X.

    07/13/2024
    FGF21 protects against ischaemia reperfusion injury in normal and fatty livers.

    FGF21 protects against ischaemia reperfusion injury in normal and fatty livers.
    Ma Y, Singhal G, Chan SS, Wang C, Yu H, Yin B, Pang J, Malvar G, Nasser I, Mather ML, Maratos-Flier E.

    07/3/2024
    FGF21 overexpression alleviates VSMC senescence in diabetic mice by modulating the SYK-NLRP3 inflammasome-PPARgamma-catalase pathway.

    FGF21 overexpression alleviates VSMC senescence in diabetic mice by modulating the SYK-NLRP3 inflammasome-PPARγ-catalase pathway.
    Heng Y, Wei W, Cheng L, Wu F, Dong H, Li J, Fu J, Yang B, Liang X, Liu C, Li H, Liu H, Zhang P., Free PMC Article

    06/26/2024
    FGF21 attenuates neuroinflammation following subarachnoid hemorrhage through promoting mitophagy and inhibiting the cGAS-STING pathway.

    FGF21 attenuates neuroinflammation following subarachnoid hemorrhage through promoting mitophagy and inhibiting the cGAS-STING pathway.
    Ma Y, Liu Z, Deng L, Du J, Fan Z, Ma T, Xiong J, Xiuyun X, Gu N, Di Z, Zhang Y., Free PMC Article

    05/13/2024
    Growth hormone resistance induced by amino acid deprivation in fao cells is independent of FGF21.

    Growth hormone resistance induced by amino acid deprivation in fao cells is independent of FGF21.
    Saito M, Nishi H, Takahashi SI, Hakuno F, Miyata I.

    04/30/2024
    Fibroblast growth factor 21 mitigates lupus nephritis progression via the FGF21/Irgm 1/NLRP3 inflammasome pathway.

    Fibroblast growth factor 21 mitigates lupus nephritis progression via the FGF21/Irgm 1/NLRP3 inflammasome pathway.
    Zou Y, Wang D, Sun W, Wu Q, Liu S, Ren Z, Li Y, Zhao T, Li Z, Li X, Cao W, Han J, Guo X, Ren G.

    04/22/2024
    Double knockout of FFAR4 and FGF21 aggravates metabolic disorders in mice.

    Double knockout of FFAR4 and FGF21 aggravates metabolic disorders in mice.
    Wei L, Ye X, Cui S, Li D, Zhu S.

    03/20/2024
    FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity.

    FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity.
    Minami S, Sakai S, Yamamoto T, Takabatake Y, Namba-Hamano T, Takahashi A, Matsuda J, Yonishi H, Nakamura J, Maeda S, Matsui S, Matsui I, Isaka Y., Free PMC Article

    03/11/2024
    Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21.

    Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21.
    Agius T, Emsley R, Lyon A, MacArthur MR, Kiesworo K, Faivre A, Stavart L, Lambelet M, Legouis D, de Seigneux S, Golshayan D, Lazeyras F, Yeh H, Markmann JF, Uygun K, Ocampo A, Mitchell SJ, Allagnat F, Déglise S, Longchamp A., Free PMC Article

    03/8/2024
    Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation.

    Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation.
    Manoli I, Sysol JR, Head PE, Epping MW, Gavrilova O, Crocker MK, Sloan JL, Koutsoukos SA, Wang C, Ktena YP, Mendelson S, Pass AR, Zerfas PM, Hoffmann V, Vernon HJ, Fletcher LA, Reynolds JC, Tsokos MG, Stratakis CA, Voss SD, Chen KY, Brown RJ, Hamosh A, Berry GT, Chen XS, Yanovski JA, Venditti CP., Free PMC Article

    02/24/2024
    Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R.

    Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R.
    Lund C, Ranea-Robles P, Falk S, Rausch DM, Skovbjerg G, Vibe-Petersen VK, Krauth N, Skytte JL, Vana V, Roostalu U, Pers TH, Lund J, Clemmensen C., Free PMC Article

    02/14/2024
    Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice.

    Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice.
    Delgado-Anglés A, Blasco-Roset A, Godoy-Nieto FJ, Cairó M, Villarroya F, Giralt M, Villarroya J., Free PMC Article

    02/14/2024
    ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms.

    ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms.
    Bjorkman SH, Marti A, Jena J, García-Peña LM, Weatherford ET, Kato K, Koneru J, Chen J, Sood A, Potthoff MJ, Adams CM, Abel ED, Pereira RO., Free PMC Article

    02/1/2024
    Growth differentiation factor-15 is an IFN-gamma regulated mediator of infection-induced weight loss and the hepatic FGF21 response.

    Growth differentiation factor-15 is an IFN-γ regulated mediator of infection-induced weight loss and the hepatic FGF21 response.
    Reyes J, Zhao Y, Pandya K, Yap GS.

    01/26/2024
    Fibroblast growth factor 21 alleviates unilateral ureteral obstruction-induced renal fibrosis by inhibiting Wnt/beta-catenin signaling pathway.

    Fibroblast growth factor 21 alleviates unilateral ureteral obstruction-induced renal fibrosis by inhibiting Wnt/β-catenin signaling pathway.
    Zhong W, Jiang Y, Wang H, Luo X, Zeng T, Huang H, Xiao L, Jia N, Li A.

    01/17/2024
    FGF21 modulates hippocampal cold-shock proteins and CA2-subregion proteins in neonatal mice with hypoxia-ischemia.

    FGF21 modulates hippocampal cold-shock proteins and CA2-subregion proteins in neonatal mice with hypoxia-ischemia.
    Herrmann JR, Kochanek PM, Vagni VA, Janesko-Feldman K, Stezoski J, Gorse K, Jackson TC., Free PMC Article

    12/5/2023
    Fgf21-Dubosiella axis mediates the protective effects of exercise against NAFLD development.

    Fgf21-Dubosiella axis mediates the protective effects of exercise against NAFLD development.
    Ye X, Sun P, Lao S, Wen M, Zheng R, Lin Y, Gan L, Fan X, Wang P, Li Z, Yan X, Zhao L.

    11/30/2023
    Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.

    Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.
    Yan J, Xie J, Xu S, Guo Y, Ji K, Li C, Gao H, Zhao L.

    11/18/2023
    The roles of FGF21 and GDF15 in mediating the mitochondrial integrated stress response.

    The roles of FGF21 and GDF15 in mediating the mitochondrial integrated stress response.
    Jena J, García-Peña LM, Pereira RO., Free PMC Article

    11/2/2023
    FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue.

    FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue.
    Zhou Z, Zhang H, Tao Y, Zang J, Zhao J, Li H, Wang Y, Wang T, Zhao H, Wang F, Guo C, Zhu F, Mao H, Liu F, Zhang L, Wang Q., Free PMC Article

    10/30/2023
    Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?

    Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
    Vankrunkelsven W, Thiessen S, Derde S, Vervoort E, Derese I, Pintelon I, Matheussen H, Jans A, Goossens C, Langouche L, Van den Berghe G, Vanhorebeek I., Free PMC Article

    08/7/2023
    Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21.

    Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21.
    Klein Hazebroek M, Laterveer R, Kutschke M, Ramšak Marčeta V, Barthem CS, Keipert S., Free PMC Article

    06/26/2023
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