| Measurement of neutral ceramidase activity in vitro and in vivo. | Measurement of neutral ceramidase activity in vitro and in vivo.
Simoes M, Saleh A, Choi YM, Airola MV, Haley JD, Coant N. | 04/2/2022 |
| Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis. | Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Zhu H, Klement JD, Lu C, Redd PS, Yang D, Smith AD, Poschel DB, Zou J, Liu D, Wang PG, Ostrov D, Coant N, Hannun YA, Colby AH, Grinstaff MW, Liu K., Free PMC Article | 08/7/2021 |
| Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer. | Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer.
Coant N, Hannun YA., Free PMC Article | 03/7/2020 |
| The structural basis for ceramide recognition and hydrolysis by human neutral ceramidase has been uncovered. | Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.
Airola MV, Allen WJ, Pulkoski-Gross MJ, Obeid LM, Rizzo RC, Hannun YA., Free PMC Article | 05/21/2016 |
| These results demonstrate for the first time that adiponectin inhibits TNFalpha-induced inflammatory response via Cav1-mediated ceramidase recruitment and activation in an AdipoR1-dependent fashion. | Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.
Wang Y, Wang X, Lau WB, Yuan Y, Booth D, Li JJ, Scalia R, Preston K, Gao E, Koch W, Ma XL., Free PMC Article | 05/3/2014 |
| cloned a 3000 bp region upstream of the translational start site of the nCDase gene | Transcriptional regulation of the human neutral ceramidase gene.
O'Neill SM, Yun JK, Fox TE, Kester M., Free PMC Article | 08/27/2011 |
| c-Jun/AP-1 signaling may, in part, regulate serum-induced nCDase gene transcription | AP-1 binding transcriptionally regulates human neutral ceramidase.
O'Neill SM, Houck KL, Yun JK, Fox TE, Kester M., Free PMC Article | 08/27/2011 |
| Both acidic ceramidase (aCDase) and neutral ceramidase (nCDase) activities declined after low- and high-UVB, but returned to normal only in low-UVB cells | Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.
Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM. | 10/23/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 12/2/2009 |
| serine palmitoyltransferase and ceramidase are two major ceramide metabolizing enzymes that may have roles in psoriatic epidermis | A study on altered expression of serine palmitoyltransferase and ceramidase in psoriatic skin lesion.
Hong KK, Cho HR, Ju WC, Cho Y, Kim NI., Free PMC Article | 01/21/2010 |
| the purification and characterization of neutral ceramidase from human ileostomy content, using octanoyl-[(14)C]sphingosine as substrate | Purification and characterization of human intestinal neutral ceramidase.
Ohlsson L, Palmberg C, Duan RD, Olsson M, Bergman T, Nilsson A. | 01/21/2010 |
| Important for the generation of sphgosine 1 phosphqte (S1P) and S1P-mediated cell proliferation and survival. | Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P.
Xu R, Jin J, Hu W, Sun W, Bielawski J, Szulc Z, Taha T, Obeid LM, Mao C. | 01/21/2010 |
| Blocking acid ceramidase but not sphingosine kinase activity in alveolar macrophages led to decreased ERK and Akt activity and induction of cell death. | Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity.
Monick MM, Mallampalli RK, Bradford M, McCoy D, Gross TJ, Flaherty DM, Powers LS, Cameron K, Kelly S, Merrill AH Jr, Hunninghake GW. | 01/21/2010 |
| the present study identified a novel amidase sequence containing a critical serine residue that may function as a nucleophile in the hydrolytic attack on the amide bond present in ceramide | Identification of a novel amidase motif in neutral ceramidase.
Galadari S, Wu BX, Mao C, Roddy P, El Bawab S, Hannun YA., Free PMC Article | 01/21/2010 |
| Neutral ceramidase is localized mainly in plasma membranes. | Subcellular localization of human neutral ceramidase expressed in HEK293 cells.
Hwang YH, Tani M, Nakagawa T, Okino N, Ito M. | 01/21/2010 |