| METTL3-mediated ANXA2 inhibition confers neuroprotection in ischemic stroke: Evidence from in vivo and in vitro studies. | METTL3-mediated ANXA2 inhibition confers neuroprotection in ischemic stroke: Evidence from in vivo and in vitro studies.
Liu B, Xing Z, Song F, Li D, Zhao B, Xu C, Xia W, Ji H. | 06/3/2023 |
| Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions. | Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions.
Li DW, Qi XD, Zhang CH, Sun WP. | 02/12/2022 |
| ANGII increases Annexin-A2 nucleic acid-binding activity and elevates protein levels of the NFAT5 transcription factor in kidneys of hypertensive rats. | NFAT5 regulates renal gene expression in response to angiotensin II through Annexin-A2-mediated posttranscriptional regulation in hypertensive rats.
Fähling M, Paliege A, Jönsson S, Becirovic-Agic M, Melville JM, Skogstrand T, Hultström M. | 11/30/2019 |
| The present study found that social isolation during adolescence resulted in abnormal locomotor, emotional and cognitive behaviors and increased the expression of GFAP, ANXA2 and VIM in PFC of adult rats. | Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats.
Sun L, Min L, Zhou H, Li M, Shao F, Wang W. | 04/21/2018 |
| Cav-1 participates upstream of ANXA2 in the activation of ERK1/2 and NF-kappaB. | Annexin A2-modulated proliferation of pulmonary arterial smooth muscle cells depends on caveolae and caveolin-1 in hepatopulmonary syndrome.
Liao L, Zheng B, Yi B, Liu C, Chen L, Zeng Z, Gao J. | 10/21/2017 |
| The results indicate that ANXA2 is critical for the integrity of the blood-testis barrier and the timely release of spermatids. | Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis.
Chojnacka K, Bilinska B, Mruk DD. | 10/7/2017 |
| Concordant with the levels of AnxA2, the levels of both LC3 and collagen VI (COL VI) were decreased in the LPS group but not in the LPS + CORM group. Given the established roles of AnxA2 in fibrinolysis as well as intracellular vesicle trafficking, AnxA2 down-regulation should play an important role in the pathogenesis of septic lung injuries. | A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung.
Unuma K, Aki T, Noritake K, Funakoshi T, Uemura K. | 06/24/2017 |
| Our data suggested that ANXA2 might play important roles in CNS pathophysiology after spinal cord injury. | The upregulation of annexin A2 after spinal cord injury in rats may have implication for astrocyte proliferation.
Chen J, Cui Z, Yang S, Wu C, Li W, Bao G, Xu G, Sun Y, Wang L, Zhang J. | 03/11/2017 |
| Oxidative stress causes the incorporation of pTyr23AnxA2 into extracellular vesicles. | Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2.
Grindheim AK, Hollås H, Raddum AM, Saraste J, Vedeler A., Free PMC Article | 12/17/2016 |
| Alterations of Annexin A2 may be involved in tissue-type plasminogen activator-dependent plasticity after peripheral nerve injury and have an important role in neuropathic pain. | Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator.
Yamanaka H, Kobayashi K, Okubo M, Noguchi K. | 10/22/2016 |
| role in the mesothelial phagocytosis of crocidolite and may serve as its receptor | Receptor role of the annexin A2 in the mesothelial endocytosis of crocidolite fibers.
Yamashita K, Nagai H, Toyokuni S. | 09/26/2015 |
| Our results support a model whereby AnxA2 limits the availability of TRPA1 channels to regulate nociceptive signaling in vertebrates. | Annexin A2 regulates TRPA1-dependent nociception.
Avenali L, Narayanan P, Rouwette T, Cervellini I, Sereda M, Gomez-Varela D, Schmidt M., Free PMC Article | 01/10/2015 |
| this study identifies AnxA2 as a lipid raft-associated trafficking factor for NKCC2 and provides mechanistic insight into the regulation of this essential cotransporter. | Annexin A2 mediates apical trafficking of renal Na⁺-K⁺-2Cl⁻ cotransporter.
Dathe C, Daigeler AL, Seifert W, Jankowski V, Mrowka R, Kalis R, Wanker E, Mutig K, Bachmann S, Paliege A., Free PMC Article | 05/31/2014 |
| EAhy926 endothelial cells exposed to sera from hyperphosphatemic patients also display decreased annexin II | High phosphate directly affects endothelial function by downregulating annexin II.
Di Marco GS, König M, Stock C, Wiesinger A, Hillebrand U, Reiermann S, Reuter S, Amler S, Köhler G, Buck F, Fobker M, Kümpers P, Oberleithner H, Hausberg M, Lang D, Pavenstädt H, Brand M. | 08/3/2013 |
| Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells. | Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells.
Alvares K, Stern PH, Veis A., Free PMC Article | 07/13/2013 |
| Annexin A2 is associated with TRPV4 and regulates TRPV4-mediated calcium ion influx and substance P release in dorsal root ganglion neurons. | Functional interaction of TRPV4 channel protein with annexin A2 in DRG.
Ning L, Wang C, Ding X, Zhang Y, Wang X, Yue S. | 06/15/2013 |
| Clathrin expression and formation of clathrin-coated pits were critically required for endocytotic internalization of progastrin; in the absence of clathrin, progastrin failed to activate p38MAPK/ERKs. | Clathrin mediates endocytosis of progastrin and activates MAPKs: role of cell surface annexin A2.
Sarkar S, Kantara C, Singh P., Free PMC Article | 06/2/2012 |
| This study identified 22 differentially expressed proteins related to liver fibrosis, and verified a potential biomarker (ANXA2) for non-invasive diagnosis of immune liver fibrosis. | Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis.
Zhang L, Peng X, Zhang Z, Feng Y, Jia X, Shi Y, Yang H, Zhang Z, Zhang X, Liu L, Yin L, Yuan Z. | 07/26/2010 |
| Annexin A2 promotes choroidal neovascularization by increasing vascular endothelial growth factor expression in a rat model of argon laser coagulation-induced choroidal neovascularization. | Annexin A2 promotes choroidal neovascularization by increasing vascular endothelial growth factor expression in a rat model of argon laser coagulation-induced choroidal neovascularization.
Zhao SH, Pan DY, Zhang Y, Wu JH, Liu X, Xu Y. | 07/5/2010 |
| Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. | Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke.
Zhu H, Fan X, Yu Z, Liu J, Murata Y, Lu J, Zhao S, Hajjar KA, Lo EH, Wang X., Free PMC Article | 06/28/2010 |
| results demonstrate various levels of annexin II expression within the aortic wall of rats with experimental abdominal aortic aneurysm | Expression of annexin II in experimental abdominal aortic aneurysms.
Hayashi T, Morishita E, Ohtake H, Oda Y, Asakura H, Nakao S. | 04/12/2010 |
| annexin 2 has a dual role, first as a regulator of v-Src trafficking and targeting and second as a v-Src effector in the reorganization of actin | Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation.
Hayes MJ, Moss SE., Free PMC Article | 01/21/2010 |
| Rab14 also co-localized in part with annexin A2 and lamellar bodies in alveolar type II cells | Annexin A2 interactions with Rab14 in alveolar type II cells.
Gou D, Mishra A, Weng T, Su L, Chintagari NR, Wang Z, Zhang H, Gao L, Wang P, Stricker HM, Liu L., Free PMC Article | 01/21/2010 |
| These data suggest that annexin A2 and SNAP-23 are involved in the same pathway in the regulation of lung surfactant secretion. | Physical and functional interactions of SNAP-23 with annexin A2.
Wang P, Chintagari NR, Gou D, Su L, Liu L., Free PMC Article | 01/21/2010 |
| novel phospholipid-binding specificity for annexin 2 consistent with a role in mediating the interaction between the macropinosome surface and the polymerized actin tail. | Annexin 2 binding to phosphatidylinositol 4,5-bisphosphate on endocytic vesicles is regulated by the stress response pathway.
Hayes MJ, Merrifield CJ, Shao D, Ayala-Sanmartin J, Schorey CD, Levine TP, Proust J, Curran J, Bailly M, Moss SE., Free PMC Article | 01/21/2010 |