| Meta-analysis of the association of prosaposin polymorphisms rs4747203 and rs885828 with risk of Parkinson's disease. | Meta-analysis of the association of prosaposin polymorphisms rs4747203 and rs885828 with risk of Parkinson's disease.
Zhu L, Zhang X, Guan Y, Zhu Y, Zhou Q, Liu B, Ren H, Yang X. | 03/29/2024 |
| Hyperglycosylation of prosaposin in tumor dendritic cells drives immune escape. | Hyperglycosylation of prosaposin in tumor dendritic cells drives immune escape.
Sharma P, Zhang X, Ly K, Kim JH, Wan Q, Kim J, Lou M, Kain L, Teyton L, Winau F., | 02/5/2024 |
| Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury. | Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury.
Qiu X, Guo Y, Liu MF, Zhang B, Li J, Wei JF, Li M., Free PMC Article | 11/28/2023 |
| Prosaposin, tumor-secreted protein, promotes pancreatic cancer progression by decreasing tumor-infiltrating lymphocytes. | Prosaposin, tumor-secreted protein, promotes pancreatic cancer progression by decreasing tumor-infiltrating lymphocytes.
Miyahara Y, Takano S, Sogawa K, Tomizawa S, Furukawa K, Takayashiki T, Kuboki S, Ohtsuka M., Free PMC Article | 08/13/2022 |
| Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo. | Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo.
Devireddy S, Ferguson SM., Free PMC Article | 02/19/2022 |
| Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease. | Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease.
Mendsaikhan A, Tooyama I, Serrano GE, Beach TG, Walker DG., Free PMC Article | 01/1/2022 |
| Genetic Analysis of Prosaposin, the Lysosomal Storage Disorder Gene in Parkinson's Disease. | Genetic Analysis of Prosaposin, the Lysosomal Storage Disorder Gene in Parkinson's Disease.
Chen YP, Gu XJ, Ou RW, Zhang LY, Hou YB, Liu KC, Cao B, Wei QQ, Song W, Zhao B, Wu Y, Cheng JQ, Shang HF. | 10/30/2021 |
| PSAP intronic variants around saposin D domain and Parkinson's disease. | PSAP intronic variants around saposin D domain and Parkinson's disease.
Lin ZH, Ruan Y, Xue NJ, Fang Y, Pu JL, Zhang BR. | 04/24/2021 |
| Glucosylsphingosine but not Saposin C, is the target antigen in Gaucher disease-associated gammopathy. | Glucosylsphingosine but not Saposin C, is the target antigen in Gaucher disease-associated gammopathy.
Nair S, Bar N, Xu ML, Dhodapkar M, Mistry PK., Free PMC Article | 12/26/2020 |
| Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology. | Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.
Mendsaikhan A, Tooyama I, Bellier JP, Serrano GE, Sue LI, Lue LF, Beach TG, Walker DG., Free PMC Article | 09/12/2020 |
| Our data provide novel genetic evidence for the involvement of the PSAP saposin D domain in Parkinson's disease. | Variants in saposin D domain of prosaposin gene linked to Parkinson's disease.
Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Wu YR, Matsuda J, Hattori N. | 08/1/2020 |
| This study revealed that circVAPA contributes to Hepatocellular carcinoma (HCC) cell proliferation through sponging miR-377-3p and thereby disinhibiting prosaposin (PSAP), shedding light on a new insight into HCC initiation and progression | Circular RNA circVAPA Promotes Cell Proliferation in Hepatocellular Carcinoma.
Liu C, Zhong X, Li J, Xu F. | 07/11/2020 |
| PSAP played a regulatory role in glioblastoma invasion and epithelial mesenchymal transformation-like processes via the TGF-beta1/Smad signaling pathway. | Prosaposin is a biomarker of mesenchymal glioblastoma and regulates mesenchymal transition through the TGF-β1/Smad signaling pathway.
Jiang Y, Zhou J, Hou D, Luo P, Gao H, Ma Y, Chen YS, Li L, Zou D, Zhang H, Zhang Y, Jing Z. | 04/18/2020 |
| No role for PSAP or SapC variants in Parkinson disease. | Sequencing of the GBA coactivator, Saposin C, in Parkinson disease.
Ouled Amar Bencheikh B, Leveille E, Ruskey JA, Spiegelman D, Liong C, Fon EA, Rouleau GA, Dauvilliers Y, Dupre N, Alcalay RN, Gan-Or Z., Free PMC Article | 09/21/2019 |
| Two novel variants in the PSAP gene were identified in a patient with metachromatic leukodystrophy. | Late Infantile Metachromatic Leukodystrophy Due to Novel Pathogenic Variants in the PSAP Gene.
Kolnikova M, Jungova P, Skopkova M, Foltan T, Gasperikova D, Mattosova S, Chandoga J. | 06/1/2019 |
| Saposin C or its precursor (PSAP) function as an androgen-agonist and upregulate androgen receptor and prostate-specific antigen expression/activity in androgen-responsive prostate cancer cells LNCaP, TRAMP-C1 and -C2, and CWR 22RV1. | Prosaposin upregulates AR and PSA expression and activity in prostate cancer cells (LNCaP).
Koochekpour S, Lee TJ, Wang R, Culig Z, Delorme N, Caffey S, Marrero L, Aguirre J. | 05/31/2019 |
| The prosaposin gene is amplified in human metastatic AI PCa cell lines and punch biopsy samples of prostate cancer xenografts and lymph node metastases. | Amplification and overexpression of prosaposin in prostate cancer.
Koochekpour S, Zhuang YJ, Beroukhim R, Hsieh CL, Hofer MD, Zhau HE, Hiraiwa M, Pattan DY, Ware JL, Luftig RB, Sandhoff K, Sawyers CL, Pienta KJ, Rubin MA, Vessella RL, Sellers WR, Sartor O. | 05/31/2019 |
| The findings of this study suggest that PSAP can promote glioma cell proliferation via the TLR4/NF-kappaB signaling pathway and may be an important target for glioma treatment. | Prosaposin promotes the proliferation and tumorigenesis of glioma through toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway.
Jiang Y, Zhou J, Luo P, Gao H, Ma Y, Chen YS, Li L, Zou D, Zhang Y, Jing Z., Free PMC Article | 03/16/2019 |
| Accumulating evidence suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved are not known. Here, we show that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides that are essential for lysosomal glycosphingolipid degradation. | Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.
Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F., Free PMC Article | 12/1/2018 |
| Both PSAP reduction and overexpression lead to significantly elevated extracellular progranulin (PGRN) levels. Intriguingly, PSAP knockdown increases PGRN monomers, whereas PSAP overexpression increases PGRN oligomers, partly through a protein-protein interaction. | Prosaposin is a regulator of progranulin levels and oligomerization.
Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, Fuchsberger C, Fowler S, Teslovich TM, Manning AK, Kumar S, Curran J, Lehman D, Abecasis G, Duggirala R, Pottier C, Zahir HA, Crook JE, Karydas A, Mitic L, Sun Y, Dickson DW, Bu G, Herz J, Yu G, Miller BL, Ferguson S, Petersen RC, Graff-Radford N, Blangero J, Rademakers R., Free PMC Article | 09/15/2018 |
| Study demonstrated that the binding of CST3 and PSAP decreased the inhibitory effects of CST3 on proteinase in vitro. The co-localization of both proteins was detected in cultured cells and in Bunina body-containing motor neurons from patients with amyotrophic lateral sclerosis, suggesting that they might be involved in the process of Bunina body formation. | Co-localization of cystatin C and prosaposin in cultured neurons and in anterior horn neurons with amyotrophic lateral sclerosis.
Wada Y, Nagai A, Sheikh AM, Onoda K, Terashima M, Shiota Y, Araki A, Yamaguchi S. | 08/18/2018 |
| This report documents the successful use of plasma lysoSLs profiling in the PSAP deficiency diagnosis, as a reliable and informative tool to obtain a preliminary information in infantile cases with complex traits displaying severe neurological signs and visceral involvement. | Clinical, biochemical and molecular characterization of prosaposin deficiency.
Motta M, Tatti M, Furlan F, Celato A, Di Fruscio G, Polo G, Manara R, Nigro V, Tartaglia M, Burlina A, Salvioli R. | 07/1/2017 |
| an extensive review of all the PSAP-causative variants published in the literature to date, accounting for a total of 10 PSAP allele types (review) | Mutation Update of ARSA and PSAP Genes Causing Metachromatic Leukodystrophy.
Cesani M, Lorioli L, Grossi S, Amico G, Fumagalli F, Spiga I, Filocamo M, Biffi A. | 12/17/2016 |
| Our findings suggest a novel pharmacological approach to Sap C deficiency directed to treat major secondary pathological aspects in this disorder. | BCM-95 and (2-hydroxypropyl)-β-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts.
Tatti M, Motta M, Scarpa S, Di Bartolomeo S, Cianfanelli V, Tartaglia M, Salvioli R. | 05/21/2016 |
| PSAP is a secreted biomarker. | Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer.
Ali A, Creevey L, Hao Y, McCartan D, O'Gaora P, Hill A, Young L, McIlroy M., Free PMC Article | 04/23/2016 |