| Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes. | Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes.
Wang L, Zhou Z, Xu X, Li Y, Zhang R, Yu Z, Huang X, Zang S, Sun T., Free PMC Article | 01/17/2024 |
| N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis. | N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis.
Kawataka M, Ouhara K, Kobayashi E, Shinoda K, Tobe K, Fujimori R, Mizuno N, Sugiyama E, Ozawa T, Kishi H. | 12/5/2023 |
| Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis. | Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis.
Henderson SR, Horsley H, Frankel P, Khosravi M, Goble T, Carter S, Antonelou M, Evans RDR, Zhang X, Chu TY, Lin HH, Gordon S, Salama AD., Free PMC Article | 05/24/2023 |
| Identification of proteinase 3 autoreactive CD4[+]T cells and their T-cell receptor repertoires in antineutrophil cytoplasmic antibody-associated vasculitis. | Identification of proteinase 3 autoreactive CD4(+)T cells and their T-cell receptor repertoires in antineutrophil cytoplasmic antibody-associated vasculitis.
Sharma RK, Yoosuf N, Afonso M, Scheffschick A, Avik A, Bartoletti A, Horuluoglu B, Diaz Boada JS, Boddul SK, Jonasdottir AD, Lövström B, Brauner H, Raposo B, Chemin K, Bruchfeld A, Gunnarsson I, Malmström V. | 04/26/2023 |
| Risk of relapse of ANCA-associated vasculitis among patients homozygous for the proteinase 3 gene Val119Ile polymorphism. | Risk of relapse of ANCA-associated vasculitis among patients homozygous for the proteinase 3 gene Val119Ile polymorphism.
Casal Moura M, Deng Z, Brooks SR, Tew W, Fervenza FC, Kallenberg CGM, Langford CA, Merkel PA, Monach PA, Seo P, Spiera RF, St Clair EW, Stone JH, Prunotto M, Grayson PC, Specks U., Free PMC Article | 04/4/2023 |
| Identification of PRTN3 as a novel biomarker for the diagnosis of early gastric cance. | Identification of PRTN3 as a novel biomarker for the diagnosis of early gastric cance.
Guo D, Zhang B, Wu D, Hu X, Tu H. | 03/20/2023 |
| PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease. | PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease.
Chen DP, Aiello CP, McCoy D, Stamey T, Yang J, Hogan SL, Hu Y, Derebail VK, Wu EY, Jennette JC, Falk RJ, Ciavatta DJ., Free PMC Article | 03/16/2023 |
| Immunological Interaction of HLA-DPB1 and Proteinase 3 in ANCA Vasculitis is Associated with Clinical Disease Activity. | Immunological Interaction of HLA-DPB1 and Proteinase 3 in ANCA Vasculitis is Associated with Clinical Disease Activity.
Chen DP, McInnis EA, Wu EY, Stember KG, Hogan SL, Hu Y, Henderson CD, Blazek LN, Mallal S, Karosiene E, Peters B, Sidney J, James EA, Kwok WW, Jennette JC, Ciavatta DJ, Falk RJ, Free ME., Free PMC Article | 08/13/2022 |
| Human Proteinase 3, an important autoantigen of c-ANCA associated vasculitis, shares cross-reactive epitopes with serine protease allergens from mites: an in silico analysis. | Human Proteinase 3, an important autoantigen of c-ANCA associated vasculitis, shares cross-reactive epitopes with serine protease allergens from mites: an in silico analysis.
Buendía E, Marlon M, Parra O, Sánchez M, Sánchez A, Sánchez J, Viasus D., Free PMC Article | 05/28/2022 |
| Increased Neutrophil elastase and proteinase 3 are closely associated with occurrence and severity of stroke and acute myocardial infarction in patients with type 2 diabetes mellitus. | Increased Neutrophil elastase and proteinase 3 are closely associated with occurrence and severity of stroke and acute myocardial infarction in patients with type 2 diabetes mellitus.
Wang L, Pan J, Sun Y, Zong S, Zhang R, Li Y, Yu Z, Liu J, Zang S. | 05/7/2022 |
| Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation. | Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation.
Marino SF, Jerke U, Rolle S, Daumke O, Kettritz R., Free PMC Article | 04/30/2022 |
| Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis. | Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis.
Patterson EK, Gillio-Meina C, Martin CM, Fraser DD, Van Nynatten LR, Slessarev M, Cepinskas G., Free PMC Article | 12/18/2021 |
| Pathogenicity of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody in Granulomatosis With Polyangiitis: Implications as Biomarker and Future Therapies. | Pathogenicity of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody in Granulomatosis With Polyangiitis: Implications as Biomarker and Future Therapies.
Granel J, Korkmaz B, Nouar D, Weiss SAI, Jenne DE, Lemoine R, Hoarau C., Free PMC Article | 07/3/2021 |
| Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin. | Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin.
N'Guessan K, Grzywa R, Seren S, Gabant G, Juliano MA, Moniatte M, van Dorsselaer A, Bieth JG, Kellenberger C, Gauthier F, Wysocka M, Lesner A, Sienczyk M, Cadene M, Korkmaz B. | 05/22/2021 |
| Immunopathogenesis of ANCA-Associated Vasculitis. | Immunopathogenesis of ANCA-Associated Vasculitis.
Kronbichler A, Lee KH, Denicolò S, Choi D, Lee H, Ahn D, Kim KH, Lee JH, Kim H, Hwang M, Jung SW, Lee C, Lee H, Sung H, Lee D, Hwang J, Kim S, Hwang I, Kim DY, Kim HJ, Cho G, Cho Y, Kim D, Choi M, Park J, Park J, Tizaoui K, Li H, Smith L, Koyanagi A, Jacob L, Gauckler P, Shin JI., Free PMC Article | 02/27/2021 |
| Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases. | Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases.
Herdendorf TJ, Stapels DAC, Rooijakkers SHM, Geisbrecht BV., Free PMC Article | 12/26/2020 |
| A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma. | A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Wei Z, Wu B, Wang L, Zhang J. | 12/19/2020 |
| Proteinase 3 Autoreactivity in Anti-Neutrophil Cytoplasmic Antibody-associated vasculitis-Immunological versus clinical features. | Proteinase 3 Autoreactivity in Anti-Neutrophil Cytoplasmic Antibody-associated vasculitis-Immunological versus clinical features.
Sharma RK, Lövström B, Gunnarsson I, Malmström V., Free PMC Article | 11/28/2020 |
| Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3. | Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3.
Fu Z, Akula S, Thorpe M, Hellman L., Free PMC Article | 10/10/2020 |
| Knockdown of PR3 inhibits IkappaBalpha cleavage and enhances the sensitivities of AML cells to differentiation inducers. The level of PR3 mRNA was relatively higher in newly diagnosed AML patients than in those patients with complete remission. PR3 expression and its involvement in IkappaBalpha cleavage might be closely associated with AML. | A novel specific cleavage of IκBα protein in acute myeloid leukemia cells involves protease PR3.
Wang MM, Zhuang LK, Zhang YT, Xia D, Pan XR, Tong JH. | 06/27/2020 |
| PR3-ANCA-associated vasculitis is strongly associated with the HLA-DPB1 alleles HLA-DPB1*04:01, -DPB1*04:02 and -DPB1*23:01, which share amino acid sequences crucial for the peptide-binding groove. | PR3-ANCA-associated vasculitis is associated with a specific motif in the peptide-binding cleft of HLA-DP molecules.
Gregersen JW, Erikstrup C, Ivarsen P, Glerup R, Krarup E, Keller KK, Hansen IT, Møller BK. | 04/18/2020 |
| The data show that a low P4HA2 and high PRTN3 expression correlates with poor survival in patients with pancreatic cancer, indicating the involvement of collagen deposition in the restraint of the tumor. | Low P4HA2 and high PRTN3 expression predicts poor survival in patients with pancreatic cancer.
Hu D, Ansari D, Zhou Q, Sasor A, Said Hilmersson K, Andersson R. | 03/14/2020 |
| findings demonstrate a novel mechanism whereby PMN- and AML-associated mP3 inhibits T cell proliferation via direct LRP1 and mP3 interaction, and we identify P3 as a novel target to modulate immunity in myeloid leukemia and autoimmune disease. | Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation.
Yang TH, St John LS, Garber HR, Kerros C, Ruisaard KE, Clise-Dwyer K, Alatrash G, Ma Q, Molldrem JJ., Free PMC Article | 07/6/2019 |
| The lung extracellular matrix is vulnerable to pathological structural changes upon upregulation of serine proteases, including cathepsin G (CG) and proteinase 3 (PR3). | Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease.
Gudmann NS, Manon-Jensen T, Sand JMB, Diefenbach C, Sun S, Danielsen A, Karsdal MA, Leeming DJ. | 02/23/2019 |
| PR3 is involved in triggering inflammatory pathways, disrupting cellular signalling, degrading key structural proteins, and pathogen response.PR3 dysfunction may play a critical role in many processes central to the pathophysiology of COPD and other chronic neutrophilic human diseases. | Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases.
Crisford H, Sapey E, Stockley RA., Free PMC Article | 12/22/2018 |