| POI-associated EIF4ENIF1 mutations exhibit impaired translation regulation abilities. | POI-associated EIF4ENIF1 mutations exhibit impaired translation regulation abilities.
Ding Y, Chen S, Jin J, Sun Y, Chu C, Kee K, Xin M, Li L. | 08/6/2024 |
| An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein. | An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein.
Zuberek J, Warzecha M, Dobrowolski M, Modrak-Wojcik A., Free PMC Article | 11/1/2023 |
| EIF4ENIF1 variants in two patients with non-syndromic premature ovarian insufficiency. | EIF4ENIF1 variants in two patients with non-syndromic premature ovarian insufficiency.
Shang L, Ren S, Yang X, Zhang F, Jin L, Zhang X, Wu Y. | 10/22/2022 |
| we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. | The DDX6-4E-T interaction mediates translational repression and P-body assembly.
Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N., Free PMC Article | 06/24/2017 |
| our data support a model where 4E-T promotes mRNA turnover by physically linking the 3'-terminal mRNA decay machinery to the 5' cap | The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5' and 3' Termini of Target mRNAs.
Nishimura T, Padamsi Z, Fakim H, Milette S, Dunham WH, Gingras AC, Fabian MR. | 04/16/2016 |
| neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. | An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.
Yang G, Smibert CA, Kaplan DR, Miller FD. | 02/14/2015 |
| that while both eIF4E1 and eIF4E2 bind 4E-T via the canonical YX 4Lvarphi sequence, nearby downstream sequences also influence eIF4E:4E-T interactions | Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells.
Kubacka D, Kamenska A, Broomhead H, Minshall N, Darzynkiewicz E, Standart N., Free PMC Article | 06/21/2014 |
| This work has demonstrated the conserved yet unpredicted and surprising translational control of bound mRNAs by 4E-T, which does not involve eIF4E, nor P-body components. | Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.
Kamenska A, Lu WT, Kubacka D, Broomhead H, Minshall N, Bushell M, Standart N., Free PMC Article | 05/24/2014 |
| Data demonstrate that EIF4ENIF1 is associated with dominantly inherited primary ovarian insufficiency. | Mutations in eIF4ENIF1 are associated with primary ovarian insufficiency.
Kasippillai T, MacArthur DG, Kirby A, Thomas B, Lambalk CB, Daly MJ, Welt CK., Free PMC Article | 11/16/2013 |
| The c-Jun N-terminal kinase (JNK) is targeted to processing bodies in response to oxidative stress and promotes the phosphorylation of 4E-T. | Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.
Cargnello M, Tcherkezian J, Dorn JF, Huttlin EL, Maddox PS, Gygi SP, Roux PP., Free PMC Article | 01/5/2013 |
| Hsp90 probably contributes to the correct localization of eIF4E and 4E-T to stress granules and also to the interaction between eIF4E and eIF4G, both of which may be needed for eIF4E to acquire the physiological functionality | The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G.
Suzuki Y, Minami M, Suzuki M, Abe K, Zenno S, Tsujimoto M, Matsumoto K, Minami Y., Free PMC Article | 01/21/2010 |
| Overexpression of eIF4E-T triggers the movement of eIF4E into the processing bodies. | Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation.
Lee HC, Cho H, Kim YK. | 01/21/2010 |
| A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay is described. | A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.
Ferraiuolo MA, Basak S, Dostie J, Murray EL, Schoenberg DR, Sonenberg N., Free PMC Article | 01/21/2010 |
| human P bodies contain the cap-binding protein eIF4E and the related factor eIF4E-transporter (eIF4E-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation | A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.
Andrei MA, Ingelfinger D, Heintzmann R, Achsel T, Rivera-Pomar R, Lührmann R., Free PMC Article | 01/21/2010 |