| Downregulated Reprimo by LINC00467 participates in the growth and metastasis of gastric cancer. | Downregulated Reprimo by LINC00467 participates in the growth and metastasis of gastric cancer.
Wu Y, Du J., Free PMC Article | 05/28/2022 |
| rawing on embryonic and adult expression patterns, we address the potential relevance of RPRM and RPRML in cancer. Active investigation or analytical research in the coming years should contribute to novel translational applications of this poorly understood gene family as potential biomarkers and development of novel cancer therapies. | The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties.
Amigo JD, Opazo JC, Jorquera R, Wichmann IA, Garcia-Bloj BA, Alarcon MA, Owen GI, Corvalán AH., Free PMC Article | 10/27/2018 |
| Reprimo methylation was found more frequently in malignant intraductal papillary mucinous neoplasm (IPMN), suggesting reprimo methylation is involved in malignant transformation of IPMNs. | Effect of Reprimo Down-regulation on Malignant Transformation of Intraductal Papillary Mucinous Neoplasm.
Nakazato T, Suzuki Y, Tanaka R, Abe N, Masaki T, Mori T, Ohkura Y, Sugiyama M. | 10/13/2018 |
| data suggest that ERalpha expression in breast cancer may affect the DNA methylation of CpG-island in the RPRM gene. | Reprimo, a Potential p53-Dependent Tumor Suppressor Gene, Is Frequently Hypermethylated in Estrogen Receptor α-Positive Breast Cancer.
Buchegger K, Riquelme I, Viscarra T, Ili C, Brebi P, Huang TH, Roa JC., Free PMC Article | 04/28/2018 |
| tissue-specific expression patterns of the RPRM transcripts and protein are conserved between zebrafish and humans. We propose the zebrafish as a powerful tool to elucidate the both physiological and pathological roles of the RPRM gene family | Reprimo tissue-specific expression pattern is conserved between zebrafish and human.
Figueroa RJ, Carrasco-Avino G, Wichmann IA, Lange M, Owen GI, Siekmann AF, Corvalán AH, Opazo JC, Amigo JD., Free PMC Article | 09/23/2017 |
| Results provide evidence that RPRM promoter methylation is highly associated with gastric cancer. | Methylation-Sensitive Melt Curve Analysis of the Reprimo Gene Methylation in Gastric Cancer.
Wang H, Zheng Y, Lai J, Luo Q, Ke H, Chen Q., Free PMC Article | 07/8/2017 |
| The DNA methylation of both Reprimo and hMLH1 genes depressed the protein expression, and may participate in the occurrence and progression and gastric cancer | Implication of Reprimo and hMLH1 gene methylation in early diagnosis of gastric carcinoma.
Liu L, Yang X., Free PMC Article | 11/5/2016 |
| tp53-dependent G2 arrest mediator candidate gene, Reprimo, is down-regulated by promoter hypermethylation in pediatric acute myeloid leukemia | tp53-dependent G2 arrest mediator candidate gene, Reprimo, is down-regulated by promoter hypermethylation in pediatric acute myeloid leukemia.
Tao YF, Li ZH, Wang NN, Fang F, Xu LX, Pan J. | 09/10/2016 |
| Positive association between RPRM and p73 expression suggest that other members of the p53 gene family may participate in the regulation of RPRM expression. | Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer.
Saavedra K, Valbuena J, Olivares W, Marchant MJ, Rodríguez A, Torres-Estay V, Carrasco-Avino G, Guzmán L, Aguayo F, Roa JC, Corvalán AH, Saavedra K, Valbuena J, Olivares W, Marchant MJ, Rodríguez A, Torres-Estay V, Carrasco-Avino G, Guzmán L, Aguayo F, Roa JC, Corvalán AH., Free PMC Articles: PMC4425545, PMC4425545 | 04/30/2016 |
| Loss of expression of Reprimo (RPRM), a p53-induced cell cycle arrest gene correlates with invasive stage of tumor progression and p73 expression in gastric cancer. These findings suggest that other members of the p53 gene family may participate in the regulation of RPRM expression | Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer.
Saavedra K, Valbuena J, Olivares W, Marchant MJ, Rodríguez A, Torres-Estay V, Carrasco-Avino G, Guzmán L, Aguayo F, Roa JC, Corvalán AH, Saavedra K, Valbuena J, Olivares W, Marchant MJ, Rodríguez A, Torres-Estay V, Carrasco-Avino G, Guzmán L, Aguayo F, Roa JC, Corvalán AH., Free PMC Articles: PMC4425545, PMC4425545 | 08/18/2015 |
| Reprimo expression is normally induced in response to DNA damage, acting as a novel tumor suppressor in gastric cancer; however, Reprimo methylation abrogates its expression and effects | DNA damage-inducible gene, reprimo functions as a tumor suppressor and is suppressed by promoter methylation in gastric cancer.
Ooki A, Yamashita K, Yamaguchi K, Mondal A, Nishimiya H, Watanabe M. | 06/14/2014 |
| study concludes that LMP-1 may induce cell cycle arrest at G(2)/M progression via upregulation of 14-3-3sigma and Reprimo | Epstein-Barr virus-encoded latent membrane protein-1 upregulates 14-3-3σ and Reprimo to confer G(2)/M phase cell cycle arrest.
Yeo KS, Mohidin TB, Ng CC. | 06/29/2013 |
| RPRM is transiently up-regulated at a posttranscriptional level in times of cellular stress to restrict cell survival, proliferation, and tumor formation | Reprimo (RPRM) is a novel tumor suppressor in pituitary tumors and regulates survival, proliferation, and tumorigenicity.
Xu M, Knox AJ, Michaelis KA, Kiseljak-Vassiliades K, Kleinschmidt-DeMasters BK, Lillehei KO, Wierman ME., Free PMC Article | 09/22/2012 |
| Loss of Reprimo and S100A2 expressions occurs frequently in gastric adenocarcinomas. The expressions of Reprimo and S100A2 may be potential biomarkers for gastric adenocarcinomas detection. | Loss of Reprimo and S100A2 expression in human gastric adenocarcinoma.
Luo J, Zhu Y, Yang G, Gong L, Wang B, Liu H. | 01/7/2012 |
| these data implicate a novel role for HDAC7 and FoxA1 in estrogen repression of RPRM. | Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM.
Malik S, Jiang S, Garee JP, Verdin E, Lee AV, O'Malley BW, Zhang M, Belaguli NS, Oesterreich S., Free PMC Article | 01/25/2010 |
| Aberrant hypermethylation of Reprimo is high in primary gastric cancer as well as in pair plasma samples. In plasma from asymptomatic controls, Reprimo is infrequently methylated. Reprimo is a potential biomarker for early detection of gastric cancer. | Reprimo as a potential biomarker for early detection in gastric cancer.
Bernal C, Aguayo F, Villarroel C, Vargas M, Díaz I, Ossandon FJ, Santibáñez E, Palma M, Aravena E, Barrientos C, Corvalan AH. | 11/25/2008 |
| An association between the Reprimo 824G>C heterozygote and diverticular disease may exist on the basis of deviation from Hardy-Weinberg equilibrium. | Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study.
Beasley WD, Beynon J, Jenkins GJ, Parry JM, Beasley WD, Beynon J, Jenkins GJ, Parry JM. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study.
Beasley WD, Beynon J, Jenkins GJ, Parry JM, Beasley WD, Beynon J, Jenkins GJ, Parry JM. | 04/3/2008 |
| Results suggest that aberrant methylation of Reprimo is a common event in pancreatic carcinogenesis and is associated with genetic instability. | Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma.
Sato N, Fukushima N, Matsubayashi H, Iacobuzio-Donahue CA, Yeo CJ, Goggins M. | 01/21/2010 |