| PRSS2 regulates EMT and metastasis via MMP-9 in gastric cancer. | PRSS2 regulates EMT and metastasis via MMP-9 in gastric cancer.
Wang F, Yi J, Chen Y, Bai X, Lu C, Feng S, Zhou X. | 08/9/2023 |
| High expression of serine protease 2 (PRSS2) associated with invasion, metastasis, and proliferation in gastric cancer. | High expression of serine protease 2 (PRSS2) associated with invasion, metastasis, and proliferation in gastric cancer.
Qin H, Zhang S, Shen L, Mao C, Gao G, Wang H., Free PMC Article | 04/26/2023 |
| Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression. | Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression.
Fu D, Blobner BM, Greer PJ, Lafyatis R, Bellin MD, Whitcomb DC, Prospective Autos Study, GREAT1 Study, North American Pancreatitis Study Group., Free PMC Article | 02/4/2023 |
| PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. | PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.
Sui L, Wang S, Ganguly D, El Rayes TP, Askeland C, Børretzen A, Sim D, Halvorsen OJ, Knutsvik G, Arnes J, Aziz S, Haukaas S, Foulkes WD, Bielenberg DR, Ziemys A, Mittal V, Brekken RA, Akslen LA, Watnick RS., Free PMC Article | 12/31/2022 |
| Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis. | Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis.
Zou WB, Cooper DN, Masson E, Pu N, Liao Z, Férec C, Chen JM. | 08/6/2022 |
| TATI, TAT-2, and CRP as Prognostic Factors in Colorectal Cancer. | TATI, TAT-2, and CRP as Prognostic Factors in Colorectal Cancer.
Björkman K, Kaprio T, Beilmann-Lehtonen I, Stenman UH, Böckelman C, Haglund C. | 01/15/2022 |
| Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis. | Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.
Szabó A, Toldi V, Gazda LD, Demcsák A, Tőzsér J, Sahin-Tóth M., Free PMC Article | 08/28/2021 |
| Role of the Common PRSS1-PRSS2 Haplotype in Alcoholic and Non-Alcoholic Chronic Pancreatitis: Meta- and Re-Analyses. | Role of the Common PRSS1-PRSS2 Haplotype in Alcoholic and Non-Alcoholic Chronic Pancreatitis: Meta- and Re-Analyses.
Herzig AF, Génin E, Cooper DN, Masson E, Férec C, Chen JM., Free PMC Article | 07/31/2021 |
| Data indicate association between polymorphism rs10273639 of the PRSS1-PRSS2 locus and pancreatitis development. | Alcohol Consumption and Cigarette Smoking are Important Modifiers of the Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men.
Polonikov AV, Samgina TA, Nazarenko PM, Bushueva OY, Ivanov VP. | 03/10/2018 |
| evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis | Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India.
Avanthi SU, Ravi Kanth VV, Agarwal J, Lakhtakia S, Gangineni K, Rao GV, Reddy DN, Talukdar R. | 09/24/2016 |
| PRSS2 single nucleotide polymorphism associated with the development of alcoholic pancreatitis. | Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, Férec C, Drenth JP, Witt H, Rosendahl J, PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators. | 10/31/2015 |
| Serum trypsinogen-2 is associated with pancreatic cancer and pancreatitis. | Correlations between serum trypsinogen-2 and pancreatic cancer.
Cao J, Xia C, Cui T, Guo H, Li H, Ren Y, Wang S. | 06/20/2015 |
| Trypsin-1 and trypsin-2 appear to have a function in the degradation of vitreous type II collagen. | Trypsin-mediated enzymatic degradation of type II collagen in the human vitreous.
van Deemter M, Kuijer R, Harm Pas H, Jacoba van der Worp R, Hooymans JM, Los LI., Free PMC Article | 09/28/2013 |
| Two associations with alcoholic pancreatitis at genome-wide significance were identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. | Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, Alzheimer's Disease Genetics Consortium, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Conwell D, Coté GA, Cotton PB, DiSario J, Farrer LA, Forsmark CE, Johnstone M, Gardner TB, Gelrud A, Greenhalf W, Haines JL, Hartman DJ, Hawes RA, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem NM, Money ME, Muniraj T, Papachristou GI, Pericak-Vance MA, Romagnuolo J, Schellenberg GD, Sherman S, Simon P, Singh VP, Slivka A, Stolz D, Sutton R, Weiss FU, Wilcox CM, Zarnescu NO, Wisniewski SR, O'Connell MR, Kienholz ML, Roeder K, Barmada MM, Yadav D, Devlin B., Free PMC Article | 02/16/2013 |
| trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms. | Trypsin-2 enhances carcinoma invasion by processing tight junctions and activating ProMT1-MMP.
Vilen ST, Suojanen J, Salas F, Risteli J, Ylipalosaari M, Itkonen O, Koistinen H, Baumann M, Stenman UH, Sorsa T, Salo T, Nyberg P. | 12/8/2012 |
| Elevation of urine trypsinogen 2 is an independent risk factor for pancreatic fistula after pancreaticoduodenectomy. | Elevation of urine trypsinogen 2 is an independent risk factor for pancreatic fistula after pancreaticoduodenectomy.
Uemura K, Murakami Y, Sudo T, Hashimoto Y, Nakashima A, Yamaoka E, Sueda T. | 11/24/2012 |
| Report a simple, rapid, easy, and noninvasive urinary trypsinogen-2 test can diagnose or rule out most cases of acute pancreatitis. | Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis.
Mayumi T, Inui K, Maetani I, Yokoe M, Sakamoto T, Yoshida M, Ko S, Hirata K, Takada T, Urinary Trypsinogen-2 Dipstick for Acute Pancreatitis Study Group of Japanese Society of Abdominal Emergency Medicine (UtrAP Study Group). | 11/24/2012 |
| Data show that urinary trypsinogen-2 dipstick test is a useful test for early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. | Rapid urinary trypsinogen-2 test strip in the diagnosis of pancreatitis after endoscopic retrograde cholangiopancreatography.
Tseng CW, Chen CC, Lin SZ, Chang FY, Lin HC, Lee SD. | 03/17/2012 |
| results suggest that trypsinogen-2 is a more sensitive marker than amylase, and it can be useful in early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. | Assessment of trypsinogen-2 levels as an early diagnostic for post-endoscopic retrograde cholangiopancreatography pancreatitis.
Kobayashi K, Sasaki T, Serikawa M, Inoue M, Itsuki H, Chayama K. | 03/17/2012 |
| A genetic variant of PRSS2 may contribute to the low prevalence of pancreatitis in primary hyperparathyroidism patients. | Multifactorial genesis of pancreatitis in primary hyperparathyroidism: evidence for "protective" (PRSS2) and "destructive" (CTRC) genetic factors.
Felderbauer P, Karakas E, Fendrich V, Lebert R, Bartsch DK, Bulut K. | 05/28/2011 |
| Hyperexpression of the PRSS2 gene is associated with pancreatic cancer. | Identification of pancreatic juice proteins as biomarkers of pancreatic cancer.
Gao J, Zhu F, Lv S, Li Z, Ling Z, Gong Y, Jie C, Ma L. | 10/4/2010 |
| there was a borderline statistically significant association between pancreatic cancer and HAT/HCT but no association between pancreatic cancer and HAT, HCT. | Pre-diagnostic levels of anionic trypsinogen, cationic trypsinogen, and pancreatic secretory trypsin inhibitor in relation to pancreatic cancer risk.
Johansen D, Manjer J, Regner S, Lindkvist B. | 09/27/2010 |
| Urine trypsinogen-2 test may be an important diagnostic tool in excluding the diagnosis of acute pancreatitis; it has a negative predictive value. | The role of urine trypsinogen-2 test in the differential diagnosis of acute pancreatitis in the Emergency Department.
Cevik Y, Kavalci C, Ozer M, Daş M, Kiyak G, Ozdoğan M. | 08/23/2010 |
| Results do not support the urinary trypsinogen-2 dipstick test (UTDT) to replace standard plasma amylase for the diagnosis of AP, however, the test demonstrated an adequate sensitivity to be used for rapid early screening of AP in daily clinics. | Urinary trypsinogen-2 dipstick in acute pancreatitis.
Andersen AM, Novovic S, Ersbøll AK, Jorgensen LN, Hansen MB. | 05/3/2010 |
| G191R PRSS2 is a rare allele in the Indian population and the data suggest a nonsignificant trend towards a protective effect from tropical calcific pancreatitis in Indians. | Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis.
Sundaresan S, Chacko A, Dutta AK, Bhatia E, Witt H, Te Morsche RH, Jansen JB, Drenth JP. | 01/21/2010 |