| LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway. | LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway.
Zhang X, Wu H, Yan X, Ma J, Chen Z., Free PMC Article | 12/3/2022 |
| [Prognostic implications and functional enrichment analysis of LTB4R in patients with acute myeloid leukemia]. | [Prognostic implications and functional enrichment analysis of LTB4R in patients with acute myeloid leukemia].
Zhang X, Zhang X, Liu P, Liu K, Li W, Chen Q, Ma W., Free PMC Article | 05/7/2022 |
| Leukotriene B4 receptor 2 correlates with prognosis and immune infiltration in clear cell renal cell carcinoma. | Leukotriene B4 receptor 2 correlates with prognosis and immune infiltration in clear cell renal cell carcinoma.
Yuan X, He Y, Luo C, Wang W. | 04/23/2022 |
| Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation. | Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.
Jang JH, Park D, Park GS, Kwak DW, Park J, Yu DY, You HJ, Kim JH., Free PMC Article | 04/9/2022 |
| Prognostic and immunological value of LTB4R in pan-cancer. | Prognostic and immunological value of LTB4R in pan-cancer.
Long S, Ji S, Xiao K, Xue P, Zhu S. | 12/18/2021 |
| The critical roles of BLT2 on the functions of bronchial epithelial cells. | Leukotriene B4 receptor 2 regulates the proliferation, migration, and barrier integrity of bronchial epithelial cells.
Liu M, Shen J, Yuan H, Chen F, Song H, Qin H, Li Y, Xu J, Ye Q, Li S, Saeki K, Yokomizo T. | 09/28/2019 |
| Authors found that BLT2, a cell surface GPCR for leukotriene B4 and 12hydroxyeicosatetraenoic acid, is highly upregulated in KRAS mutant LOVO and SW480 colorectal cancer cells and plays critical roles in mediating proliferation through activation of phosphatidylinositol 3kinase (PI3K)/protein kinase B (Akt) and subsequent upregulation of cyclin D1. | Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells.
Park J, Jang JH, Kim JH. | 09/14/2019 |
| Our analysis identified six significant (Sidak corrected P < 0.05) depression-associated differentially methylated regions (DMRs); the top-ranked DMR was located in exon 1 of the LTB4R2 gene (Sidak corrected P = 1.27 x 10-14). | DNA methylation and inflammation marker profiles associated with a history of depression.
Crawford B, Craig Z, Mansell G, White I, Smith A, Spaull S, Imm J, Hannon E, Wood A, Yaghootkar H, Ji Y, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Mullins N, Lewis CM, Mill J, Murphy TM., Free PMC Article | 03/9/2019 |
| In a group of 545 breast cancer patients with metastasis, authors observed that the high-BLT2 subgroup had a lower disease-free-survival rate than the low-BLT2 subgroup. | BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer.
Park J, Jang JH, Park GS, Chung Y, You HJ, Kim JH., Free PMC Article | 10/20/2018 |
| BLT2 gene polymorphism (D196G) enhances ligand sensitivity, thereby increasing cell motility in response to low-dose ligand stimulation. | Leukotriene B(4) receptor 2 gene polymorphism (rs1950504, Asp196Gly) leads to enhanced cell motility under low-dose ligand stimulation.
Jang JH, Wei JD, Kim M, Kim JY, Cho AE, Kim JH., Free PMC Article | 08/25/2018 |
| Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury. | Leukotriene B(4) receptor type 2 protects against pneumolysin-dependent acute lung injury.
Shigematsu M, Koga T, Ishimori A, Saeki K, Ishii Y, Taketomi Y, Ohba M, Jo-Watanabe A, Okuno T, Harada N, Harayama T, Shindou H, Li JD, Murakami M, Hoka S, Yokomizo T., Free PMC Article | 06/16/2018 |
| BLT2 ligation facilitates F-actin assembly with the upregulated phosphorylation of MYPT1. | The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes.
Chiba T, Nakahara T, Hashimoto-Hachiya A, Yokomizo T, Uchi H, Furue M. | 01/27/2018 |
| Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor | Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation.
Silliman CC, Kelher MR, Khan SY, West FB, McLaughlin NJD, Elzi DJ, England K, Bjornsen J, Kuldanek SA, Banerjee A., Free PMC Article | 11/18/2017 |
| RanBPM acts as a negative regulator of BLT2 and IL8, thus attenuating the invasiveness of aggressive breast cancer cells | RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells.
Wei JD, Jang JH, Kim JH. | 06/10/2017 |
| BLT2 inhibition induces apoptosis, inhibits proliferation, colony formation and self-renewal capacity of CD34(+) cells from tyrosine kinase inhibitor - resistant blast phase-chronic myeloid leukemia patients. | Targeting of the BLT2 in chronic myeloid leukemia inhibits leukemia stem/progenitor cell function.
Xiao M, Ai H, Li T, Rajoria P, Shahu P, Li X. | 08/13/2016 |
| Data show that signal transducer and activator of transcription-3 (STAT-3) activation occurs downstream of leukotriene B4 receptor-2 (BLT2) and mediates cisplatin resistance in SK-OV-3 cells. | Leukotriene B4 receptor-2 contributes to chemoresistance of SK-OV-3 ovarian cancer cells through activation of signal transducer and activator of transcription-3-linked cascade.
Park J, Park SY, Kim JH. | 05/28/2016 |
| Authors demonstrated that MyD88 lies upstream of BLT2 in LPS-potentiated invasiveness and that this 'MyD88-BLT2' cascade mediates activation of NF-kappaB and the synthesis of IL-6 and IL-8 critical for the invasiveness and aggression of breast cancer cells. | Myeloid differentiation primary response gene 88-leukotriene B4 receptor 2 cascade mediates lipopolysaccharide-potentiated invasiveness of breast cancer cells.
Park GS, Kim JH., Free PMC Article | 03/5/2016 |
| BLT1 and BLT2 are therefore potential targets for the development of novel drugs. | Two distinct leukotriene B4 receptors, BLT1 and BLT2.
Yokomizo T. | 10/3/2015 |
| searched BLT2 downstream components and identified reactive oxygen species and nuclear factor kappaB as critical components that contribute to epithelial-mesenchymal transition in mammary epithelial cells | Ras promotes transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition via a leukotriene B4 receptor-2-linked cascade in mammary epithelial cells.
Kim H, Choi JA, Kim JH., Free PMC Article | 02/21/2015 |
| BLT2-NOX-ROS-NF-kappaB cascade induction during detachment confers a novel mechanism of anoikis resistance in prostate cancer cells and potentially contributes to prostate cancer progression. | Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells.
Lee JW, Kim JH., Free PMC Article | 01/4/2014 |
| RanBPM acts as a negative regulator of BLT2 signaling to attenuate BLT2-mediated cell motility | RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility.
Wei JD, Kim JY, Kim AK, Jang SK, Kim JH., Free PMC Article | 12/21/2013 |
| Findings indicate that BLT2 has a protective role in allergic airway inflammation and that diminished BLT2 expression in CD4(+) T cells may contribute to the pathophysiology of asthma. | Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia.
Matsunaga Y, Fukuyama S, Okuno T, Sasaki F, Matsunobu T, Asai Y, Matsumoto K, Saeki K, Oike M, Sadamura Y, Machida K, Nakanishi Y, Kubo M, Yokomizo T, Inoue H. | 12/21/2013 |
| BLT2 is a novel therapeutic target that sensitises drug-resistant breast cancer cells to paclitaxel. | A leukotriene B4 receptor-2 is associated with paclitaxel resistance in MCF-7/DOX breast cancer cells.
Kim H, Park GS, Lee JE, Kim JH., Free PMC Article | 10/19/2013 |
| Findings suggest that, in bronchial epithelial cells, cigarette smoke extracts (CSE) promote induction of pro-inflammatory BLT2 receptors and activate mechanisms leading to increased neutrophil adhesion. | Cigarette smoke increases BLT2 receptor functions in bronchial epithelial cells: in vitro and ex vivo evidence.
Pace E, Ferraro M, Di Vincenzo S, Bruno A, Giarratano A, Scafidi V, Lipari L, Di Benedetto DV, Sciarrino S, Gjomarkaj M., Free PMC Article | 07/6/2013 |
| our study demonstrates that a BLT2 up-regulates IL-8 production , thereby contributing to the invasiveness of these aggressive breast cancer cells. | BLT2 up-regulates interleukin-8 production and promotes the invasiveness of breast cancer cells.
Kim H, Choi JA, Park GS, Kim JH., Free PMC Article | 05/25/2013 |