| The molecular neural mechanism underlying the acceleration of brain aging due to Dcf1 deficiency. | The molecular neural mechanism underlying the acceleration of brain aging due to Dcf1 deficiency.
Zhou H, Wang J, Wen T. | 10/26/2023 |
| Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice. | Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice.
Meng J, Han L, Zheng N, Wang T, Xu H, Jiang Y, Wang Z, Liu Z, Zheng Q, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang YW., Free PMC Article | 07/2/2022 |
| A preliminary study on abnormal brain function and autistic behavior in mice caused by dcf1 deletion. | A preliminary study on abnormal brain function and autistic behavior in mice caused by dcf1 deletion.
Lin R, Zhou H, Diao X, Wang J, Feng R, Wen T. | 01/1/2022 |
| Dendritic cell factor 1 deletion leads to developmental defects in mushroom-shaped dendritic spines. | Dendritic cell factor 1 deletion leads to developmental defects in mushroom-shaped dendritic spines.
Zheng L, Liu Q, Wen T. | 10/16/2021 |
| Deletion of Dcf1 Reduces Amyloid-beta Aggregation and Mitigates Memory Deficits. | Deletion of Dcf1 Reduces Amyloid-β Aggregation and Mitigates Memory Deficits.
Li WH, Gan LH, Ma FF, Feng RL, Wang J, Li YH, Sun YY, Wang YJ, Diao X, Qian FY, Wen TQ. | 09/18/2021 |
| TMEM59 protects against cerebral ischemic stroke by suppressing pyroptosis and microglial activation. | TMEM59 protects against cerebral ischemic stroke by suppressing pyroptosis and microglial activation.
Zhang L, Wang T, Chen XF, Xu ZX, Cao JB, Sun H. | 09/4/2021 |
| TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities. | TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities.
Liu Z, Ning J, Zheng X, Meng J, Han L, Zheng H, Zhong L, Chen XF, Zhang X, Luo H, Can D, Xu H, Zhang YW., Free PMC Article | 03/28/2021 |
| Dcf1 deletion presents alterations in gut microbiota of mice similar to Parkinson's disease. | Dcf1 deletion presents alterations in gut microbiota of mice similar to Parkinson's disease.
Li W, Zhao Q, Wang J, Wang Y, Wen T. | 02/13/2021 |
| Dcf1 protein affects both memory and anxiety by regulating NMDA and AMPA receptors. | Dcf1 Affects Memory and Anxiety by Regulating NMDA and AMPA Receptors.
Wang Y, Liu Q, Xie J, Feng R, Ma F, Wang F, Shen S, Wen T. | 04/11/2020 |
| Dcf1 triggers the dendritic spine and synaptic function through the recruitment of Lcn2 and activation of PSD95-NMDAR signaling. | Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition.
Liu Q, Feng R, Chen Y, Luo G, Yan H, Chen L, Lin R, Ding Y, Wen T. | 12/22/2018 |
| The Dcf1 knockout upregulates ATP1B1 expression in the hippocampus and DCF1 interaction with ATP1B1 in astrocytes impaired their structural plasticity. | Interaction of DCF1 with ATP1B1 induces impairment in astrocyte structural plasticity via the P38 signaling pathway.
Wang J, Zhou F, Wang D, Li J, Lu D, Li Q, Zhou H, Li W, Wang Q, Wu Y, Xie J, Wen T. | 12/22/2018 |
| The results of this study revealed that DCF1-KO mice presented a visual behavioral deficit, higher GAD67 levels, and lower electrophysiological activity in V1 via the GABA system. | Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex.
Shi J, Li Q, Wen T., Free PMC Article | 09/22/2018 |
| Dcf1 plays an important role in behavior induced by the mushroom body in Drosophila and the dentate gyrus (DG) in mice and provides novel insights into their functions. Dcf1 rescued the optogenetic suppression of behavior by halorhodopsin in transgenic animals. | Dcf1 Improves Behavior Deficit in Drosophila and Mice Caused by Optogenetic Suppression.
Liu Q, Gan L, Ni J, Chen Y, Chen Y, Huang Z, Huang X, Wen T. | 07/14/2018 |
| Notably, we observed a significant increase in the ATP concentration in Dcf1(-/-) mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY and revealed that Dcf1 plays a critical role in energy balance. | Dcf1 regulates neuropeptide expression and maintains energy balance.
Liu Q, Chen Y, Li Q, Wu L, Wen T. | 03/24/2018 |
| This study shows that losing of dendritic cell factor 1 in the nervous system induces a social interaction deficit. | Dopamine and dopamine receptor D1 associated with decreased social interaction.
Liu Q, Shi J, Lin R, Wen T. | 12/16/2017 |
| MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis. | MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis.
Li X, Feng R, Huang C, Wang H, Wang J, Zhang Z, Yan H, Wen T. | 12/22/2012 |
| The expression of tmem59 is an important factor contributing to Alzheimer's disease. | Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles.
Zhang L, Ju X, Cheng Y, Guo X, Wen T., Free PMC Article | 12/24/2011 |
| Overexpression of the dcf1 gene, the NSCs were maintained in undifferentiated status. After the dcf1 gene was silenced, cells tended to differentiate into neurons and astrocytes. | A novel function of dcf1 during the differentiation of neural stem cells in vitro.
Wang L, Wang J, Wu Y, Wu J, Pang S, Pan R, Wen T. | 03/9/2011 |