| Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells. | Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
Liu Y, Hu G, Yang S, Yao M, Liu Z, Yan C, Wen Y, Ping W, Wang J, Song Y, Dong X, Pan G, Yao H., Free PMC Article | 11/14/2023 |
| USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. | USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
Liu C, Sun L, Tan Y, Wang Q, Luo T, Li C, Yao N, Xie Y, Yi X, Zhu Y, Guo T, Ji J., Free PMC Article | 06/7/2023 |
| Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells. | Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
Henry S, Kokity L, Pirity MK., Free PMC Article | 02/10/2023 |
| RYBP regulates Pax6 during in vitro neural differentiation of mouse embryonic stem cells. | RYBP regulates Pax6 during in vitro neural differentiation of mouse embryonic stem cells.
Sutus E, Henry S, Adorján L, Kovács G, Pirity MK., Free PMC Article | 03/19/2022 |
| RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern. | RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern.
Li Q, Chen J, Liang F, Zhang J, Qu W, Huang X, Cheng X, Zhao X, Yang Z, Xu S, Li X., Free PMC Article | 03/5/2022 |
| Rybp orchestrates spermatogenesis via regulating meiosis and sperm motility in mice. | Rybp orchestrates spermatogenesis via regulating meiosis and sperm motility in mice.
Tian Q, Guo SM, Xie SM, Yin Y, Zhou LQ., Free PMC Article | 08/28/2021 |
| Ring 1 and YY1 Binding Protein Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis. | Ring 1 and YY1 Binding Protein Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis.
He Z, Yan RG, Zhang XN, Yang QE., Free PMC Article | 10/3/2020 |
| RYBP is important for cardiac progenitor cell development and sarcomere formation. | RYBP is important for cardiac progenitor cell development and sarcomere formation.
Henry S, Szabó V, Sutus E, Pirity MK., Free PMC Article | 09/19/2020 |
| The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division. | RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
Zhao J, Wang M, Chang L, Yu J, Song A, Liu C, Huang W, Zhang T, Wu X, Shen X, Zhu B, Li G. | 04/25/2020 |
| Study reveals a complex pattern of gene regulation by SCL, ETO2 and RYBP. Genome-wide analyses shows locus-specific binding of ETO2 and RYBP on SCL's 778 activated and repressed genes. | SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
Chagraoui H, Kristiansen MS, Ruiz JP, Serra-Barros A, Richter J, Hall-Ponselé E, Gray N, Waithe D, Clark K, Hublitz P, Repapi E, Otto G, Sopp P, Taylor S, Thongjuea S, Vyas P, Porcher C., Free PMC Article | 01/19/2019 |
| Here, the authors discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation. | RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
Rose NR, King HW, Blackledge NP, Fursova NA, Ember KJ, Fischer R, Kessler BM, Klose RJ., Free PMC Article | 11/4/2017 |
| these results reveal important functions of DDX5 in regulating reprogramming and highlight the importance of a Ddx5-miR125b-Rybp axis in controlling cell fate. | RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.
Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP, Yao H. | 08/5/2017 |
| These results show that a sustained regulation of the B-1-to-B-2 B cell lineage switch is needed throughout adult life and that RYBP plays an important role in keeping B-2 dominance, most likely independently of its Polycomb affiliation. | Role of Polycomb RYBP in Maintaining the B-1-to-B-2 B-Cell Lineage Switch in Adult Hematopoiesis.
Calés C, Pavón L, Starowicz K, Pérez C, Bravo M, Ikawa T, Koseki H, Vidal M., Free PMC Article | 07/30/2016 |
| The data provide evidence for a previously unrecognized function of Rybp in heart development and point out the importance of germ cell lineage gene silencing during somatic differentiation. | Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation.
Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, Acsai K, Hegedus Z, Krebs S, Dinnyes A, Pirity MK. | 06/11/2016 |
| Although the genomic localization of the Cbx7- and RYBP-containing PRC1 complexes overlaps in certain genes, it can also be mutually exclusive. | RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells.
Morey L, Aloia L, Cozzuto L, Benitah SA, Di Croce L. | 07/20/2013 |
| identify Rybp as a novel regulator of myogenesis that co-acts with YY1 to silence miR-29 and other myogenic loci. | A novel target of microRNA-29, Ring1 and YY1-binding protein (Rybp), negatively regulates skeletal myogenesis.
Zhou L, Wang L, Lu L, Jiang P, Sun H, Wang H., Free PMC Article | 10/20/2012 |
| Rybp efficiently represses endogenous retroviruses (murine endogenous retrovirus [MuERV] class) and preimplantation (including zygotic genome activation stage)- and germ line-specific genes. | RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells.
Hisada K, Sánchez C, Endo TA, Endoh M, Román-Trufero M, Sharif J, Koseki H, Vidal M., Free PMC Article | 04/14/2012 |
| RYBP-PRC1 is recruited to target loci in mESCs and is also involved in Xist RNA-mediated silencing, the latter suggesting a wider role in Polycomb silencing. | RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3.
Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J, Bezstarosti K, Taylor S, Ura H, Koide H, Wutz A, Vidal M, Elderkin S, Brockdorff N., Free PMC Article | 04/7/2012 |
| These findings suggest that Rybp and Hippi may functionally interact in the apoptotic processes that accompany normal murine neural development. | Rybp interacts with Hippi and enhances Hippi-mediated apoptosis.
Stanton SE, Blanck JK, Locker J, Schreiber-Agus N. | 01/21/2010 |
| Rybp/DEDAF is required for early postimplantation and for central nervous system development | Rybp/DEDAF is required for early postimplantation and for central nervous system development.
Pirity MK, Locker J, Schreiber-Agus N., Free PMC Article | 01/21/2010 |
| multiple functions for Rybp in regulating mouse retinal and lens development are mediated by genetic, epigenetic and physical interactions between these genes and proteins | Rybp, a polycomb complex-associated protein, is required for mouse eye development.
Pirity MK, Wang WL, Wolf LV, Tamm ER, Schreiber-Agus N, Cvekl A., Free PMC Article | 01/21/2010 |
| The Rybp interacting PcG protein Ring1B, a known ubiquitin E3 ligase, promotes Rybp ubiquitination; one target of Rybp's ubiquitin binding domain appears to be ubiquitinated histone H2A | The Polycomb-associated protein Rybp is a ubiquitin binding protein.
Arrigoni R, Alam SL, Wamstad JA, Bardwell VJ, Sundquist WI, Schreiber-Agus N. | 01/21/2010 |