| PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds. | Expression of Prostatic Acid Phosphatase in Rat Circumvallate Papillae.
Nishida K, Kubota T, Matsumoto S, Kato J, Watanabe Y, Yamamoto A, Furui M, Ohishi A, Nagasawa K., Free PMC Article | 07/29/2017 |
| These findings demonstrate that PAP secreted by PCa cells in OB bone metastases increases osteoprotegerin and plays a critical role in the vicious cross talk between cancer and bone cells. | Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases.
Kirschenbaum A, Izadmehr S, Yao S, O'Connor-Chapman KL, Huang A, Gregoriades EM, Yakar S, Levine AC., Free PMC Article | 05/27/2017 |
| functional PAP(thorn) neurons are essential for the analgesic effect, which is mediated by NGF-trkA signaling. | EXPRESS: NGF-trkA signaling modulates the analgesic effects of prostatic acid phosphatase in resiniferatoxin-induced neuropathy.
Wu CH, Ho WY, Lee YC, Lin CL, Hsieh YL., Free PMC Article | 12/31/2016 |
| TMPAP is involved in the control of GABAergic tone in the brain also through exocytosis, and that PAP deficiency produces a distinct neurological phenotype. | Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations.
Nousiainen HO, Quintero IB, Myöhänen TT, Voikar V, Mijatovic J, Segerstråle M, Herrala AM, Kulesskaya N, Pulkka AE, Kivinummi T, Abo-Ramadan U, Taira T, Piepponen TP, Rauvala H, Vihko P., Free PMC Article | 01/17/2015 |
| In male mouse saliva prostatic acid phosphatase regulates salivation. | Prostatic acid phosphatase is the main acid phosphatase with 5'-ectonucleotidase activity in the male mouse saliva and regulates salivation.
Araujo CL, Quintero IB, Kipar A, Herrala AM, Pulkka AE, Saarinen L, Hautaniemi S, Vihko P. | 07/19/2014 |
| Data indicate that prostate acid phosphatase-based peptide vaccine PAP-114-128 peptide appears to be a relevant for the treatment of prostate cancer. | Novel prostate acid phosphatase-based peptide vaccination strategy induces antigen-specific T-cell responses and limits tumour growth in mice.
Saif JM, Vadakekolathu J, Rane SS, McDonald D, Ahmad M, Mathieu M, Pockley AG, Durrant L, Metheringham R, Rees RC, McArdle SE. | 06/28/2014 |
| this PAP-/- mouse model shows that TMPAP is required for the normal function of prostate in mice, and its deficiency leads to prostate adenocarcinoma. | Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma.
Quintero IB, Herrala AM, Araujo CL, Pulkka AE, Hautaniemi S, Ovaska K, Pryazhnikov E, Kulesskiy E, Ruuth MK, Soini Y, Sormunen RT, Khirug L, Vihko PT., Free PMC Article | 06/21/2014 |
| Both prostatic acid phosphatase and ecto-5'-nucleotidase generate adenosine in the dorsal spinal cord. | Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.
Street SE, Kramer NJ, Walsh PL, Taylor-Blake B, Yadav MC, King IF, Vihko P, Wightman RM, Millán JL, Zylka MJ., Free PMC Article | 10/19/2013 |
| Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. | Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine.
Hurt JK, Coleman JL, Fitzpatrick BJ, Taylor-Blake B, Bridges AS, Vihko P, Zylka MJ., Free PMC Article | 04/13/2013 |
| Experiments indicate that PAP and NT5E are the main ectonucleotidases that generate adenosine in nociceptive circuits and indicate these enzymes transform pulsatile or sustained nucleotide release into an inhibitory adenosinergic signal. | PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine.
Street SE, Walsh PL, Sowa NA, Taylor-Blake B, Guillot TS, Vihko P, Wightman RM, Zylka MJ., Free PMC Article | 05/12/2012 |
| prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth | Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
Chuang TD, Chen SJ, Lin FF, Veeramani S, Kumar S, Batra SK, Tu Y, Lin MF., Free PMC Article | 09/20/2010 |
| studies highlight similarities and differences in PAP localization within nociceptive neurons of mice and rats | Prostatic acid phosphatase is expressed in peptidergic and nonpeptidergic nociceptive neurons of mice and rats.
Taylor-Blake B, Zylka MJ., Free PMC Article | 05/31/2010 |
| PAP has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity | Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception.
Sowa NA, Vadakkan KI, Zylka MJ., Free PMC Article | 01/21/2010 |