| LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway. | LRRC8A as a central mediator promotes colon cancer metastasis by regulating PIP5K1B/PIP2 pathway.
Zhang H, Liu R, Jing Z, Li C, Fan W, Li H, Li H, Ren J, Cui S, Zhao W, Yu L, Bai Y, Liu S, Fang C, Yang W, Wei Y, Li L, Peng S. | 04/16/2024 |
| Physiological Functions of the Volume-Regulated Anion Channel VRAC/LRRC8 and the Proton-Activated Chloride Channel ASOR/TMEM206. | Physiological Functions of the Volume-Regulated Anion Channel VRAC/LRRC8 and the Proton-Activated Chloride Channel ASOR/TMEM206.
Kostritskaia Y, Klüssendorf M, Pan YE, Hassani Nia F, Kostova S, Stauber T. | 01/8/2024 |
| Swell1 channel-mediated tonic GABA release from astrocytes modulates cocaine reward. | Swell1 channel-mediated tonic GABA release from astrocytes modulates cocaine reward.
Yang J, Qiu Z., | 12/15/2023 |
| Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels. | Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels.
Liu H, Polovitskaya MM, Yang L, Li M, Li H, Han Z, Wu J, Zhang Q, Jentsch TJ, Liao J., Free PMC Article | 09/26/2023 |
| LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells. | LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells.
Zhang H, Cui S, Jing Z, Fu G, Liu R, Zhao W, Xu L, Yu L, Bai Y, Lv C, Wu M, Wei Y, Li L, Peng S. | 05/28/2023 |
| Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. | Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Gunasekar SK, Xie L, Kumar A, Hong J, Chheda PR, Kang C, Kern DM, My-Ta C, Maurer J, Heebink J, Gerber EE, Grzesik WJ, Elliot-Hudson M, Zhang Y, Key P, Kulkarni CA, Beals JW, Smith GI, Samuel I, Smith JK, Nau P, Imai Y, Sheldon RD, Taylor EB, Lerner DJ, Norris AW, Klein S, Brohawn SG, Kerns R, Sah R., Free PMC Article | 03/5/2022 |
| LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway. | LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway.
Kurashima K, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E. | 01/22/2022 |
| LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions. | LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions.
Serra SA, Stojakovic P, Amat R, Rubio-Moscardo F, Latorre P, Seisenbacher G, Canadell D, Böttcher R, Aregger M, Moffat J, de Nadal E, Valverde MA, Posas F., Free PMC Article | 12/11/2021 |
| Oxidant-resistant LRRC8A/C anion channels support superoxide production by NADPH oxidase 1. | Oxidant-resistant LRRC8A/C anion channels support superoxide production by NADPH oxidase 1.
Choi H, Rohrbough JC, Nguyen HN, Dikalova A, Lamb FS., Free PMC Article | 07/24/2021 |
| Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells. | Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells.
Yoshimoto S, Matsuda M, Kato K, Jimi E, Takeuchi H, Nakano S, Kajioka S, Matsuzaki E, Hirofuji T, Inoue R, Hirata M, Morita H. | 05/22/2021 |
| LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology. | LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology.
Yamada T, Figueroa EE, Denton JS, Strange K., Free PMC Article | 04/3/2021 |
| LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses. | LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.
Li P, Hu M, Wang C, Feng X, Zhao Z, Yang Y, Sahoo N, Gu M, Yang Y, Xiao S, Sah R, Cover TL, Chou J, Geha R, Benavides F, Hume RI, Xu H., Free PMC Article | 02/2/2021 |
| The LRRC8-mediated volume-regulated anion channel is altered in glaucoma. | The LRRC8-mediated volume-regulated anion channel is altered in glaucoma.
Gasull X, Castany M, Castellanos A, Rezola M, Andrés-Bilbé A, Canut MI, Estévez R, Borrás T, Comes N., Free PMC Article | 10/10/2020 |
| LRRC8/VRAC channels exhibit a noncanonical permeability to glutathione, which modulates epithelial-to-mesenchymal transition (EMT). | LRRC8/VRAC channels exhibit a noncanonical permeability to glutathione, which modulates epithelial-to-mesenchymal transition (EMT).
Friard J, Corinus A, Cougnon M, Tauc M, Pisani DF, Duranton C, Rubera I., Free PMC Article | 09/12/2020 |
| It discusses the recent molecular biological insights into the physiology of LRRC8A as the pore-forming components of volume-regulated anion channel (VRAC) in relation to its previously proposed roles. | More than just a pressure relief valve: physiological roles of volume-regulated LRRC8 anion channels.
Chen L, König B, Liu T, Pervaiz S, Razzaque YS, Stauber T. | 04/18/2020 |
| High LRRC8A expression is associated with Esophageal Squamous Cell Carcinoma. | LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma.
Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E. | 03/28/2020 |
| Non-vesicular release of glutamate through the glutamate-permeable volume-regulated anion channel (VRAC). Both cell swelling and receptor stimulation activated astrocytic VRAC, which requires its only obligatory subunit, Swell1. | Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke.
Yang J, Vitery MDC, Chen J, Osei-Owusu J, Chu J, Qiu Z., Free PMC Article | 03/28/2020 |
| Study revealed that LRRC8A-dependent volume-regulated anion channel (VRAC) function is essential for male germ cell survival, sperm motility and spermatogenesis and suggested that mutations in LRRC8A could be examined as a diagnostic target in human patients with coiled/deformed sperm tail morphology. | Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.
Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Jaubert J, Platt CD, Chou J, Deng M, Zhou MH, Huang Y, Gaitán-Peñas H, Guénet JL, Lin K, Lu Y, Chen T, Bedford MT, Dent SY, Richburg JH, Estévez R, Pan HL, Geha RS, Shi Q, Benavides F., Free PMC Article | 12/14/2019 |
| LRRC8A has a role in hypotonic stress response of human keratinocytes | Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume-regulated anion channels.
Trothe J, Ritzmann D, Lang V, Scholz P, Pul Ü, Kaufmann R, Buerger C, Ertongur-Fauth T. | 10/26/2019 |
| Knockdown of LRRC8A ameliorates AngII-induced cerebrovascular smooth muscle cell proliferation via inhibiting PI3K/AKT pathway, suggesting that LRRC8A may be a novel molecular target in the treatment of vascular remodeling and stroke. | Inhibition of angiotensin II-induced cerebrovascular smooth muscle cell proliferation by LRRC8A downregulation through suppressing PI3K/AKT activation.
Lu J, Xu F, Zhang J. | 10/19/2019 |
| Comparing the two conformations suggests that the LRR region is flexible and mobile, with rigid-body motions, which might be implicated in structural transitions on pore opening | Cryo-EM structures of the human volume-regulated anion channel LRRC8.
Kasuya G, Nakane T, Yokoyama T, Jia Y, Inoue M, Watanabe K, Nakamura R, Nishizawa T, Kusakizako T, Tsutsumi A, Yanagisawa H, Dohmae N, Hattori M, Ichijo H, Yan Z, Kikkawa M, Shirouzu M, Ishitani R, Nureki O. | 10/5/2019 |
| The study shows here that the short stretch preceding the first LRRC8 transmembrane domain determines volume-regulated anion channels conductance, ion permeability, and inactivation gating. Substituted-cysteine accessibility studies revealed that several of the first 15 LRRC8 residues are functionally important and exposed to a hydrophilic environment. | LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs).
Zhou P, Polovitskaya MM, Jentsch TJ., Free PMC Article | 03/9/2019 |
| a mutation in the flexible N-terminal portion of SWELL1 affects pore properties, suggesting a putative link between intracellular structures and channel regulation. This structure provides a scaffold for further dissecting the heterogeneity and mechanism of activation of VRAC. | Structure of the human volume regulated anion channel.
Kefauver JM, Saotome K, Dubin AE, Pallesen J, Cottrell CA, Cahalan SM, Qiu Z, Hong G, Crowley CS, Whitwam T, Lee WH, Ward AB, Patapoutian A., Free PMC Article | 12/22/2018 |
| using cryo-electron microscopy and X-ray crystallography, determination of the structure of a homomeric channel of the obligatory subunit LRRC8A; this work reveals the previously unknown architecture of volume-regulated anion channels and their mechanism of selective anion conduction | Structure of a volume-regulated anion channel of the LRRC8 family.
Deneka D, Sawicka M, Lam AKM, Paulino C, Dutzler R. | 12/22/2018 |
| High LRRC8A expression is associated with colon cancer cell growth and metastasis. | High expression of leucine‑rich repeat‑containing 8A is indicative of a worse outcome of colon cancer patients by enhancing cancer cell growth and metastasis.
Zhang H, Deng Z, Zhang D, Li H, Zhang L, Niu J, Zuo W, Fu R, Fan L, Ye JH, She J., Free PMC Article | 11/10/2018 |