| Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females. | Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females.
In Het Panhuis W, Tsaalbi-Shtylik A, Schönke M, van Harmelen V, Pronk ACM, Streefland TCM, Sips HCM, Afkir S, Willems van Dijk K, Rensen PCN, de Wind N, Kooijman S. | 05/14/2022 |
| Rev1 contributes to proper mitochondrial function via the PARP-NAD-SIRT1-PGC1A axis. | Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis.
Fakouri NB, Durhuus JA, Regnell CE, Angleys M, Desler C, Hasan-Olive MM, Martín-Pardillos A, Tsaalbi-Shtylik A, Thomsen K, Lauritzen M, Bohr VA, de Wind N, Bergersen LH, Rasmussen LJ., Free PMC Article | 07/20/2019 |
| These data indicate that dysregulation of cellular Rev1 levels leads to the accumulation of mutations and suppression of cell death, which accelerates the tumorigenic activities of DNA-damaging agents. | Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.
Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva EK, Kamiya K., Free PMC Article | 09/9/2017 |
| Rev1 could serve as a backup polymerase in base excision repair and could potentially contribute to activation-induced cytidine deaminase-initiated antibody diversification through this activity. | Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity.
Prasad R, Poltoratsky V, Hou EW, Wilson SH., Free PMC Article | 06/24/2017 |
| The results support the idea that Rev1 is not essential for the cellular translesion DNA synthesis functions of DNA polymerase zeta in mammalian cells. | Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells.
Hashimoto K, Bonala R, Johnson F, Grollman AP, Moriya M., Free PMC Article | 05/20/2017 |
| REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18. | REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18.
Wang Z, Huang M, Ma X, Li H, Tang T, Guo C. | 01/14/2017 |
| Rev1 is essential for the Msh2-independent generation of these transversions downstream of Ung2-induced apyrimidinic sites. | Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.
Krijger PH, Tsaalbi-Shtylik A, Wit N, van den Berk PC, de Wind N, Jacobs H. | 12/14/2013 |
| Rev1 operates in the same pathway as Ung, as emphasized by further decreased CSR in Rev1(-/-)Msh2(-/-) B cells. | Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.
Zan H, White CA, Thomas LM, Mai T, Li G, Xu Z, Zhang J, Casali P., Free PMC Article | 05/11/2013 |
| Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa | Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ.
Wojtaszek J, Lee CJ, D'Souza S, Minesinger B, Kim H, D'Andrea AD, Walker GC, Zhou P., Free PMC Article | 12/22/2012 |
| REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates. | Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1.
Ito W, Yokoi M, Sakayoshi N, Sakurai Y, Akagi J, Mitani H, Hanaoka F. | 12/8/2012 |
| two distinct surfaces of the Rev1 C-terminal domain that separately mediate the assembly of extension and insertion translesion polymerase complexes | Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ.
Wojtaszek J, Liu J, D'Souza S, Wang S, Xue Y, Walker GC, Zhou P., Free PMC Article | 10/13/2012 |
| These results reveal genetic interactions between REV1 catalytic activity and POLH and identify an alternative pathway in the generation of C to G and G to C transversions. | Analysis of mice deficient in both REV1 catalytic activity and POLH reveals an unexpected role for POLH in the generation of C to G and G to C transversions during Ig gene hypermutation.
Kano C, Hanaoka F, Wang JY. | 06/16/2012 |
| REV7 subunit of pol zeta mediated the interaction between REV3 and the REV1 C terminus. | The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.
Hashimoto K, Cho Y, Yang IY, Akagi J, Ohashi E, Tateishi S, de Wind N, Hanaoka F, Ohmori H, Moriya M., Free PMC Article | 06/16/2012 |
| role for REV1 in the generation of C:G transitions and A:T mutations suggests that REV1 is involved in multiple mutagenic pathways through functional interaction with other polymerases during the hypermutation pro | A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutation.
Masuda K, Ouchida R, Li Y, Gao X, Mori H, Wang JY. | 01/21/2010 |
| Rev1-mediated DNA damage bypass at postreplicative gaps quenches irreversible DNA damage responses. | Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.
Jansen JG, Tsaalbi-Shtylik A, Hendriks G, Gali H, Hendel A, Johansson F, Erixon K, Livneh Z, Mullenders LH, Haracska L, de Wind N., Free PMC Article | 01/21/2010 |
| REV1 is implicated in the development of carcinogen-induced lung cancer. | REV1 is implicated in the development of carcinogen-induced lung cancer.
Dumstorf CA, Mukhopadhyay S, Krishnan E, Haribabu B, McGregor WG., Free PMC Article | 01/21/2010 |
| The REV1-interaction is essential for Polkappa function in vivo. | Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function.
Ohashi E, Hanafusa T, Kamei K, Song I, Tomida J, Hashimoto H, Vaziri C, Ohmori H., Free PMC Article | 01/21/2010 |
| Here, we report that mouse REV1 can bind directly to PCNA and that monoubiquitylation of PCNA enhances this interaction. | REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo.
Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC. | 01/21/2010 |
| The BRCT domain of Rev1 is involved in regulating DNA replication during the mutagenic bypass of spontaneous and induced DNA lesions. | The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis.
Jansen JG, Tsaalbi-Shtylik A, Langerak P, Calléja F, Meijers CM, Jacobs H, de Wind N., Free PMC Article | 01/21/2010 |
| Results indicate a catalytic role of Rev1 in incorporating deoxycytidine residues, most likely opposite abasic nucleotides, during somatic hypermutation. | Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice.
Jansen JG, Langerak P, Tsaalbi-Shtylik A, van den Berk P, Jacobs H, de Wind N., Free PMC Article | 01/21/2010 |
| REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated PCNA | REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated proliferating cell nuclear antigen (PCNA).
Shen X, Jun S, O'Neal LE, Sonoda E, Bemark M, Sale JE, Li L. | 01/21/2010 |
| REV1 expression is required for the methyl methanesulfonate induced mutagenesis phenotype of Pol beta null mouse embryonic fibroblast cells. | REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast.
Poltoratsky V, Horton JK, Prasad R, Wilson SH. | 01/21/2010 |