| Urinary levels of pro-fibrotic transglutaminase 2 (TG2) may help predict progression of chronic kidney disease. | Urinary levels of pro-fibrotic transglutaminase 2 (TG2) may help predict progression of chronic kidney disease.
Da Silva Lodge M, Pullen N, Pereira M, Johnson TS., Free PMC Article | 02/19/2022 |
| Transglutaminases Are Active in Perivascular Adipose Tissue. | Transglutaminases Are Active in Perivascular Adipose Tissue.
Orr AN, Thompson JM, Lyttle JM, Watts SW., Free PMC Article | 04/24/2021 |
| Immunofluorescence staining and western blot analyses demonstrated that Tgm2 overexpression had beneficial effects on the rate of Ectomesenchymal stem cells (EMSCs) neurogenesis, and that the proliferative capacity of Tgm2 EMSCs was higher than that of controls. | Overexpression of TG2 enhances the differentiation of ectomesenchymal stem cells into neuron‑like cells and promotes functional recovery in adult rats following spinal cord injury.
Shi W, Que Y, Lv D, Bi S, Xu Z, Wang D, Zhang Z., Free PMC Article | 01/18/2020 |
| Cultured Xbp1-deficient vascular smooth muscle cells (VSMCs) demonstrated decreased levels of TG2 protein, in association with increased TG2 polyubiquitination. Moreover, IRE1alpha, and TG2-specific transamidation cross-links were increased in carotid artery neointima in Xbp1fl/fl SM22alpha-CRE+ mice. Cultured TG2-deficient VSMCs had decreased Xbp1 associated with increased IRE1alpha, and increased migration in respons... | A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia.
Serrano RL, Yu W, Graham RM, Bryan RL, Terkeltaub R., Free PMC Article | 01/4/2020 |
| Knockdown of TG2 resulted in a significant increase in cathepsin S expression, which precede the loss of neuronal viability. | Nuclear transglutaminase 2 directly regulates expression of cathepsin S in rat cortical neurons.
Ji C, Tang M, Harrison J, Paciorkowski A, Johnson GVW. | 11/16/2019 |
| Our data show that under inflammatory conditions in vitro, TG2 production is enhanced in astrocytes and microglia. We observed that in particular, astrocytes produce fibronectin that can be cross-linked and aggregated by exogenous TG2. | Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures.
Espitia Pinzón N, Brevé JJP, Bol JGJM, Drukarch B, Baron W, van Dam AM., Free PMC Article | 03/23/2019 |
| Transglutaminase 2 plays a crucial role in mediating neuronal survival through its regulation of genes involved in neurite length. | Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability.
Yunes-Medina L, Paciorkowski A, Nuzbrokh Y, Johnson GVW., Free PMC Article | 07/21/2018 |
| beta2-adrenoceptor-induced modulation of TG2 represents a novel paradigm in beta2-adrenoceptor cell signalling | β(2)-adrenoceptor-induced modulation of transglutaminase 2 transamidase activity in cardiomyoblasts.
Vyas FS, Nelson CP, Freeman F, Boocock DJ, Hargreaves AJ, Dickenson JM. | 05/5/2018 |
| An increase in TG2 activity contributes to age-associated increase in diastolic stiffness, thereby facilitating age-associated diastolic dysfunction. | Role of tissue transglutaminase in age-associated ventricular stiffness.
Oh YJ, Pau VC, Steppan J, Sikka G, Bead VR, Nyhan D, Levine BD, Berkowitz DE, Santhanam L. | 12/30/2017 |
| our findings suggest that cystamine induced vasodilatation in rat mesenteric small arteries by inhibition of receptor-coupled TG2, leading to opening of Kv channels and reduction of intracellular calcium as well as activation of a pathway sensitive to inhibitors of the mitochondrial complexes I and III | Involvement of transglutaminase 2 and voltage-gated potassium channels in cystamine vasodilatation in rat mesenteric small arteries.
Engholm M, Pinilla E, Mogensen S, Matchkov V, Hedegaard ER, Chen H, Mulvany MJ, Simonsen U., Free PMC Article | 12/17/2016 |
| Chronic allograft nephropathy was associated with upregulation of renal TG2 pathway. | Upregulation of transglutaminase and ε (γ-glutamyl)-lysine in the Fisher-Lewis rat model of chronic allograft nephropathy.
Shrestha B, Butt I, Da Silva M, Sanchez-Lara A, Wagner B, Raftery A, Johnson T, Haylor J., Free PMC Article | 11/7/2015 |
| Transglutaminase 2 activity is required for extracellular matrix degradation in arthritic synoviocytes and arthritic joints. | Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis.
Lauzier A, Charbonneau M, Paquette M, Harper K, Dubois CM., Free PMC Article | 06/27/2015 |
| Expression, activity, and functionality of TG1 and TG2 are decreased in the aorta, but not in the vena cava, from hypertensive rats. | Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls.
Petersen-Jones HG, Johnson KB, Hitomi K, Tykocki NR, Thompson JM, Watts SW., Free PMC Article | 05/16/2015 |
| a pleiotropic enzyme transglutaminase type 2 targets the allosteric coupling domain of IP3R type 1 (IP3R1) and negatively regulates IP3R1-mediated calcium signaling and autophagy by locking the subunit configurations. | Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors.
Hamada K, Terauchi A, Nakamura K, Higo T, Nukina N, Matsumoto N, Hisatsune C, Nakamura T, Mikoshiba K., Free PMC Article | 04/25/2015 |
| Modulation of transglutaminase 2 activity in H9c2 cells by PKC and PKA signalling: a role for transglutaminase 2 in cytoprotection | Modulation of transglutaminase 2 activity in H9c2 cells by PKC and PKA signalling: a role for transglutaminase 2 in cytoprotection.
Almami I, Dickenson JM, Hargreaves AJ, Bonner PL., Free PMC Article | 04/11/2015 |
| Increased vascular stiffness during aging is associated with decreased TG2 S-nitrosylation, increased TG2 cross-linking activity, and increased vascular stiffness likely the result of decreased NO bioavailability. | Exercise, vascular stiffness, and tissue transglutaminase.
Steppan J, Sikka G, Jandu S, Barodka V, Halushka MK, Flavahan NA, Belkin AM, Nyhan D, Butlin M, Avolio A, Berkowitz DE, Santhanam L., Free PMC Article | 11/22/2014 |
| TG2 may be involved not only in insulin secretion, as suggested by our previous studies in cytoplasmic INS-1E fraction, but also in the regulation of glucose-induced gene transcription. | A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets.
Sileno S, D'Oria V, Stucchi R, Alessio M, Petrini S, Bonetto V, Maechler P, Bertuzzi F, Grasso V, Paolella K, Barbetti F, Massa O., Free PMC Article | 09/20/2014 |
| data demonstrate a role of TGM2 in the pathogenesis of vascular calcification in chronic kidney disease through enhancement of matrix vesicle-extracellular matrix calcification. | Transglutaminase 2 accelerates vascular calcification in chronic kidney disease.
Chen NX, O'Neill K, Chen X, Kiattisunthorn K, Gattone VH, Moe SM. | 10/19/2013 |
| TG2 regulates S100A4-mediated mammary tumor cell migration. | The role of TG2 in regulating S100A4-mediated mammary tumour cell migration.
Wang Z, Griffin M., Free PMC Article | 08/31/2013 |
| In INS-1E, most of TG2 transamidation activity appears within the first 2 min after glucose challenge. | Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.
Russo L, Marsella C, Nardo G, Massignan T, Alessio M, Piermarini E, La Rosa S, Finzi G, Bonetto V, Bertuzzi F, Maechler P, Massa O. | 07/27/2013 |
| Inhibition of the TG2/beta-catenin signaling axis seems to prevent warfarin-induced elastocalcinosis and to control isolated systolic hypertension. | Transglutaminase inhibitors attenuate vascular calcification in a preclinical model.
Beazley KE, Banyard D, Lima F, Deasey SC, Nurminsky DI, Konoplyannikov M, Nurminskaya MV., Free PMC Article | 02/16/2013 |
| Transglutaminase 2 exacerbates experimental autoimmune encephalomyelitis through positive regulation of encephalitogenic T cell differentiation and inflammation. | Transglutaminase 2 exacerbates experimental autoimmune encephalomyelitis through positive regulation of encephalitogenic T cell differentiation and inflammation.
Oh K, Park HB, Seo MW, Byoun OJ, Lee DS. | 01/5/2013 |
| Regulation of transglutaminase 2 (TG2) directly influences the level of active TGF-beta1, and thus, TG inhibition may exert a renoprotective effect by targeting not only a direct extracellular matrix deposition but also TGF-beta1 activation and recruitment. | Do changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy?
Huang L, Haylor JL, Fisher M, Hau Z, El Nahas AM, Griffin M, Johnson TS. | 11/24/2012 |
| Warfarin-induced calcification in A10 vascular smooth muscle cells is associated with the activation of beta-catenin signaling. Vascular cells with genetically or pharmacologically reduced TG2 activity fail to activate beta-catenin in response to warfarin. | Transglutaminase 2-mediated activation of β-catenin signaling has a critical role in warfarin-induced vascular calcification.
Beazley KE, Deasey S, Lima F, Nurminskaya MV., Free PMC Article | 11/24/2012 |
| Forced expression of TG1 or TG2 proteins is sufficient to induce neuronal death in Rattus norvegicus cortical neurons in vitro. | Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.
Basso M, Berlin J, Xia L, Sleiman SF, Ko B, Haskew-Layton R, Kim E, Antonyak MA, Cerione RA, Iismaa SE, Willis D, Cho S, Ratan RR., Free PMC Article | 07/7/2012 |