| Platelet-Derived Growth Factor C Facilitates Malignant Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated Lipid Metabolism. | Platelet-Derived Growth Factor C Facilitates Malignant Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated Lipid Metabolism.
Shi YH, Liu ZD, Ma MJ, Zhao GY, Zhu YQ, Wang JQ, Yu YY, Huang XT, Ye JY, Li FX, Wang XY, Xu QC, Yin XY., Free PMC Article | 11/5/2024 |
| PDGF-C promotes cell proliferation partially via downregulating BOP1. | PDGF-C promotes cell proliferation partially via downregulating BOP1.
Li J, Hu W, Zhang R, Chen W, Li X, Tang Z. | 02/16/2024 |
| Impact of Acute High Glucose on Mitochondrial Function in a Model of Endothelial Cells: Role of PDGF-C. | Impact of Acute High Glucose on Mitochondrial Function in a Model of Endothelial Cells: Role of PDGF-C.
Rodríguez AG, Rodríguez JZ, Barreto A, Sanabria-Barrera S, Iglesias J, Morales L., Free PMC Article | 03/17/2023 |
| RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m(6)A-YTHDF2-dependent manner. | RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m(6)A-YTHDF2-dependent manner.
Tan Z, Shi S, Xu J, Liu X, Lei Y, Zhang B, Hua J, Meng Q, Wang W, Yu X, Liang C., Free PMC Article | 05/28/2022 |
| Expression and function of PDGF-C in development and stem cells. | Expression and function of PDGF-C in development and stem cells.
Tian Y, Zhan Y, Jiang Q, Lu W, Li X., Free PMC Article | 03/5/2022 |
| Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis. | Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis.
Yoon H, Tang CM, Banerjee S, Yebra M, Noh S, Burgoyne AM, Torre J, Siena M, Liu M, Klug LR, Choi YY, Hosseini M, Delgado AL, Wang Z, French RP, Lowy A, DeMatteo RP, Heinrich MC, Molinolo AA, Gutkind JS, Harismendy O, Sicklick JK., Free PMC Article | 10/16/2021 |
| Platelet-Derived Growth Factor C in Alcoholics. | Platelet-Derived Growth Factor C in Alcoholics.
Martín-González C, González-Navarrete L, Ribot-Hernández I, Vera-Delgado V, Alvisa-Negrín J, Godoy-Reyes A, Espelosín-Ortega E, Abreu-González P, González-Reimers E. | 12/26/2020 |
| The authors found PDGF-C to be highly expressed in breast carcinoma cell lines. I | An oncogenic activity of PDGF-C and its splice variant in human breast cancer.
Bottrell A, Meng YH, Najy AJ, Hurst N Jr, Kim S, Kim CJ, Kim ES, Moon A, Kim EJ, Park SY, Kim HC., Free PMC Article | 04/18/2020 |
| High PDGFC expression is associated with glioblastoma. | MicroRNA-29a inhibits glioblastoma stem cells and tumor growth by regulating the PDGF pathway.
Yang Y, Dodbele S, Park T, Glass R, Bhat K, Sulman EP, Zhang Y, Abounader R., Free PMC Article | 02/15/2020 |
| PDGF-C and PDGF-D are relatively new members of the PDGF family and are potent angiogenic and survival factors. Recent studies have demonstrated their important roles in different types of eye diseases. [review] | PDGF-C and PDGF-D in ocular diseases.
Kumar A, Li X. | 06/15/2019 |
| Numerous studies have shown that PDGF-C and PDGF-D are critical regulators of the cardiovascular system as angiogenic and survival factors. PDGF-C and PDGFD are widely expressed in many different types of cells with pleotropic effects. [review] | Platelet-derived growth factor-C and -D in the cardiovascular system and diseases.
Lee C, Li X. | 06/15/2019 |
| paracrine crosstalk between cancer cells expressing platelet-derived growth factor (PDGF)-CC and cancer-associated fibroblasts expressing the cognate receptors in human basal-like mammary carcinomas, was identified. | Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.
Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjölund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saal LH, Orsmark-Pietras C, Cordero E, Haller BK, Häkkinen J, Burvenich IJG, Lim E, Orimo A, Höglund M, Rydén L, Moch H, Scott AM, Eriksson U, Pietras K., Free PMC Article | 05/25/2019 |
| Protein expression of tumour and/or stromal cell PDGFRalpha, PDGFRbeta and PDGF-CC was evaluated in primary tumours (N = 489), synchronous lymph node metastases (N = 135) and asynchronous recurrences (N = 39) using immunohistochemistry in a prospectively maintained cohort of primary breast cancer patients | The PDGF pathway in breast cancer is linked to tumour aggressiveness, triple-negative subtype and early recurrence.
Jansson S, Aaltonen K, Bendahl PO, Falck AK, Karlsson M, Pietras K, Rydén L., Free PMC Article | 03/2/2019 |
| There are four platelet-derived growth factor (PDGF) genes (PDGFA, PDGFB, PDGFC and PDGFD) that reside on chromosomes 7, 22, 4 and 11. | PDGFs and their receptors.
Kazlauskas A., Free PMC Article | 04/22/2017 |
| We conclude that PDGF-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset | Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.
Lewandowski SA, Nilsson I, Fredriksson L, Lönnerberg P, Muhl L, Zeitelhofer M, Adzemovic MZ, Nichterwitz S, Lawrence DA, Hedlund E, Eriksson U., Free PMC Article | 11/12/2016 |
| High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes. | High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells.
Kitsunai H, Makino Y, Sakagami H, Mizumoto K, Yanagimachi T, Atageldiyeva K, Takeda Y, Fujita Y, Abiko A, Takiyama Y, Haneda M., Free PMC Article | 10/1/2016 |
| PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR). | Post-transcriptional up-regulation of PDGF-C by HuR in advanced and stressed breast cancer.
Luo NA, Qu YQ, Yang GD, Wang T, Li RL, Jia LT, Dong R., Free PMC Article | 06/27/2015 |
| Concomitant upregulation of PDGF-C with VEGF in Glioblastoma tumor cells. | Angiogenesis and expression of PDGF-C, VEGF, CD105 and HIF-1α in human glioblastoma.
Clara CA, Marie SK, de Almeida JR, Wakamatsu A, Oba-Shinjo SM, Uno M, Neville M, Rosemberg S. | 05/16/2015 |
| The results indicate that PDGF-C upregulation and calpain-3 downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins | Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness.
Ruffini F, Tentori L, Dorio AS, Arcelli D, D'Amati G, D'Atri S, Graziani G, Lacal PM. | 05/17/2014 |
| Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation. | Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation.
Son D, Na YR, Hwang ES, Seok SH., Free PMC Article | 04/26/2014 |
| Data indicate uPA (plau) and PAI1 (Serpine1) were up-regulated in human PDGF-C Tg mice, suggesting that uPA could be compensating for the loss of tissue-type plasminogen activator (tPA) activity in PDGF-C Tg; tpa KO mice. | Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation.
Riehle KJ, Johnson MM, Johansson F, Bauer RL, Hayes BJ, Gilbertson DG, Haran AC, Fausto N, Campbell JS., Free PMC Article | 04/19/2014 |
| High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma. | Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma.
Wright JH, Johnson MM, Shimizu-Albergine M, Bauer RL, Hayes BJ, Surapisitchat J, Hudkins KL, Riehle KJ, Johnson SC, Yeh MM, Bammler TK, Beyer RP, Gilbertson DG, Alpers CE, Fausto N, Campbell JS., Free PMC Article | 02/22/2014 |
| PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review] | PDGF-C: a new performer in the neurovascular interplay.
Lee C, Zhang F, Tang Z, Liu Y, Li X. | 02/15/2014 |
| Results indicate that the alpha-SMA inducing effect of M2 macrophages is in part mediated by secretion of PGDF-CC. | Platelet derived growth factor-CC secreted by M2 macrophages induces alpha-smooth muscle actin expression by dermal and gingival fibroblasts.
Glim JE, Niessen FB, Everts V, van Egmond M, Beelen RH. | 11/2/2013 |
| Single nucleotide polymorphisms in the PDGF-C gene are linked to the development of oral clefts. | Maternal transmission effect of a PDGF-C SNP on nonsyndromic cleft lip with or without palate from a Chinese population.
Wu D, Wang M, Wang X, Yin N, Song T, Li H, Zhang F, Zhang Y, Ye Z, Yu J, Wang DM, Zhao Z., Free PMC Article | 02/23/2013 |